Proteintech

Interferon beta Polyclonal Antibody

Interferon beta Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

Interferon beta Antibody (27506-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed L02 cells using IFN Beta antibody (Product # 27506-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

Interferon beta Antibody in Western Blot (WB)

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Product Details

27506-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Interferon beta Fusion Protein Ag26326 (22-187 aa encoded by BC069314)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSYNLLGFL QRSSNFQCQK LLWQLNGRLE YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN (22-187 aa encoded by BC069314)

Target Information

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A novel immunogenic cell death-related subtype classification and risk signature for predicting prognosis and immunotherapy efficacy in gastric cancer.

Frontiers in immunology

Dong B,Wu Y,Zhang J,Gu Y,Xie R,He X,Pang X,Wang X,Cui Y

Wed May 24 00:00:00 UTC 2023

CHMP4A stimulates CD8+ T-lymphocyte infiltration and inhibits breast tumor growth via the LSD1/IFNβ axis.

Cancer science

Song S,Zhang D,Chen J,Qi L,Zhang M,Yang X,Ye T,Ye Q,Lin J

Tue Aug 01 00:00:00 UTC 2023

Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.

Journal of materials chemistry. B

Yan B,Liu C,Wang S,Li H,Jiao J,Lee WSV,Zhang S,Hou Y,Hou Y,Ma X,Fan H,Lv Y,Liu X

Wed Jul 20 00:00:00 UTC 2022

Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.

International immunopharmacology

Li JJ,Liu ML,Lv JN,Chen RL,Ding K,He JQ

Tue Mar 01 00:00:00 UTC 2022

Escherichia coli infection activates the production of IFN-α and IFN-β via the JAK1/STAT1/2 signaling pathway in lung cells.

Amino acids

Jin Y,Jia Z,Cai Q,Sun Y,Liu Z

Fri Oct 01 00:00:00 UTC 2021

Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion.

Cell death & disease

Zhuang T,Yi X,Chen J,Kang P,Chen X,Chen J,Cui T,Chang Y,Ye Z,Ni Q,Wang Y,Du P,Li B,Liu L,Jian Z,Li K,Gao T,Li S,Li C

Fri Jun 12 00:00:00 UTC 2020

Role of heparan sulfate in the Zika virus entry, replication, and cell death.

Virology

Gao H,Lin Y,He J,Zhou S,Liang M,Huang C,Li X,Liu C,Zhang P

Fri Mar 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; Interferon b; Interferon beta; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1

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Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1

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UniProt ID: (Human) P01574

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Entrez Gene ID: (Human) 3456

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Function(s)

cytokine activity type I interferon receptor binding chloramphenicol O-acetyltransferase activity

Process(es)

adaptive immune response T cell activation involved in immune response B cell activation involved in immune response natural killer cell activation involved in immune response humoral immune response cell surface receptor signaling pathway blood coagulation response to virus natural killer cell activation B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein cellular response to interferon-beta B cell proliferation defense response to bacterium response to exogenous dsRNA negative regulation of viral genome replication positive regulation of innate immune response regulation of MHC class I biosynthetic process negative regulation of T cell differentiation positive regulation of transcription from RNA polymerase II promoter defense response to virus type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to exogenous dsRNA cellular response to dexamethasone stimulus cellular response to virus negative regulation of T-helper 2 cell cytokine production positive regulation of apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Interferon beta Polyclonal Antibody

Interferon beta Antibody (27506-1-AP) in ICC/IF

Product Details

27506-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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