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GenScript
Ixekizumab Recombinant Rabbit Monoclonal Antibody (19F6), MonoRab™
FIGURE: 1 / 5
Ixekizumab Antibody (A02264-40) in ELISA
Standard curve of Ixekizumab sandwich ELISA by A02264 (19F6) and A02265 (29B12). In this ELISA assay, MonoRab™ Anti-Ixekizumab Antibody (19F6), mAb, Rabbit (GenScript, A02264) was coated at a concentration of 1 μg/mL, and MonoRab™ Anti-Ixekizumab Antibody (29B12), mAb, Rabbit (GenScript, A02265) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL. In this ELISA assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square equal to 0.99921. The typical dynami... View More
Product Details
A02264-40
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
19F6
Immunogen
Ixekizumab
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Sandwich ELISA recommended dilution: 0.5-2 µg/mL; Competitive ELISA recommended dilution: 1-10 µg/mL
The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
Target Information
Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflammatory conditions. In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid Arthritis and plaque psoriasis. Ixekizumab is produced by recombinant DNA technology in a recombinant mammalian cell line and purified using standard technology for bioprocessing. Ixekizumab is comprised of two identical light chain polypeptides of 219 amino acids each and two identical heavy chain polypeptides of 445 amino acids each, and has a molecular weight of 146, 158 Daltons for the protein backbone of the molecule. It is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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