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Product Details
H00003718-M02A
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1E10
Immunogen
JAK3 (AAH28068, 1 a.a. approximately 619 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSESPP PTHPTPASPK SRLFFPPLF
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Breast-JAK3; JAK-3; JAK3B; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L JAK; L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3
Gene Aliases: JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK
UniProt ID: (Human) P52333
Entrez Gene ID: (Human) 3718
MAPK cascade
adaptive immune response
negative regulation of dendritic cell cytokine production
protein phosphorylation
enzyme linked receptor protein signaling pathway
positive regulation of cytosolic calcium ion concentration
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
cell migration
peptidyl-tyrosine phosphorylation
B cell differentiation
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
intracellular signal transduction
interleukin-4-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
tyrosine phosphorylation of Stat5 protein
T cell homeostasis
positive regulation of GTPase activity
innate immune response
negative regulation of FasL biosynthetic process
negative regulation of T-helper 1 cell differentiation
positive regulation of immune response
negative regulation of T cell activation
positive regulation of calcium ion transport
JAK-STAT cascade involved in growth hormone signaling pathway
regulation of T cell apoptotic process
negative regulation of thymocyte apoptotic process
response to interleukin-2
response to interleukin-4
response to interleukin-15
response to interleukin-9
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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