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Invitrogen
JHDM1D Polyclonal Antibody
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Product Details
PA5-52912
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human JHDM1D. Recombinant protein control fragment (Product #RP-89695).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642846
Product Specific Information
Immunogen sequence: LETLKELRED GFQPQTYLVQ GVKALHTALK LWMKKELVSE HAFEIPDNVR PGHLIKELSK VIRAIEEENG KPVKSQGIPI VCPVSRSSNE A
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 92%.
Target Information
JHDM1D histone demethylase that specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. This specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. This demethylates H3K9me2 in absence of H3K4me3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-dimethyl-L-lysine9 demethylase 7A; histone lysine demethylase JHDM1D; JmjC domain-containing histone demethylation protein 1D; jumonji C domain containing histone demethylase 1 homolog D; jumonji C domain-containing histone demethylase 1 homolog D; lysine (K)-specific demethylase 7A; Lysine-specific demethylase 7; Lysine-specific demethylase 7A
Gene Aliases: JHDM1D; KDM7; KDM7A; KIAA1718
UniProt ID: (Human) Q6ZMT4
Entrez Gene ID: (Human) 80853
iron ion binding
zinc ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
histone demethylase activity
histone demethylase activity (H3-K9 specific)
methylated histone binding
histone demethylase activity (H4-K20 specific)
histone demethylase activity (H3-K36 specific)
histone demethylase activity (H3-K27 specific)
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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