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Invitrogen
JIP1 Monoclonal Antibody (OTI1D9)
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JIP1 Antibody (MA5-27226) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human breast tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a MAPK8IP1 monoclonal antibody (Product # MA5-27226) at a dilution of 1:150.
Product Details
MA5-27226
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1D9
Immunogen
Full length human recombinant protein of MAPK8IP1 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724539
Target Information
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; Islet-brain 1; JIP-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; Mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein
Gene Aliases: IB1; JIP-1; JIP1; MAPK8IP1; PRKM8IP
UniProt ID: (Human) Q9UQF2
Entrez Gene ID: (Human) 9479
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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