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Invitrogen
JIP3 Polyclonal Antibody
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Product Details
PA5-142058
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence MEIQMDEGGGVV-C (aa 2-13).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932720
Product Specific Information
Additional Information: This antibody is expected to recognise both reported Human isoforms of this protein (as represented by NP_055948.2 and NP_001035529.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JSAP1; JUN/SAPK-associated protein 1; mitogen activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; Sunday driver 2
Gene Aliases: BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; Mapk8ip3; mKIAA1066; Syd2
UniProt ID: (Mouse) Q9ESN9
Entrez Gene ID: (Mouse) 30957
in utero embryonic development
JNK cascade
activation of JUN kinase activity
axon guidance
respiratory gaseous exchange
protein localization
post-embryonic development
positive regulation of signal transduction
regulation of gene expression
vesicle-mediated transport
forebrain development
positive regulation of JUN kinase activity
positive regulation of neuron differentiation
regulation of JNK cascade
lung alveolus development
lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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