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Product Details
39815
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N154/32
Immunogen
This JMJD2A antibody was raised against a recombinant protein corresponding to amino acids 586-674 of human JMJD2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 8, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2793352
Target Information
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A; tudor domain containing 14A
Gene Aliases: D4Ertd222e; JHDM3A; JMJD2; JMJD2A; KDM4A; KIAA0677; mKIAA0677; TDRD14A
UniProt ID: (Human) O75164, (Mouse) Q8BW72
Entrez Gene ID: (Human) 9682, (Mouse) 230674
protein binding
zinc ion binding
ubiquitin protein ligase binding
histone demethylase activity
methylated histone binding
histone demethylase activity (H3-K36 specific)
sulfonate dioxygenase activity
double-stranded DNA binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
transcription, DNA-templated
negative regulation of autophagy
negative regulation of gene expression
cardiac muscle hypertrophy in response to stress
viral process
histone demethylation
negative regulation of transcription, DNA-templated
oxidation-reduction process
histone H3-K36 demethylation
negative regulation of histone H3-K9 trimethylation
regulation of transcription, DNA-templated
positive regulation of gene expression
chromatin modification
positive regulation of neuron differentiation
negative regulation of astrocyte differentiation
negative regulation of cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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