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Proteintech
JMJD4 Polyclonal Antibody
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Product Details
21572-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
JMJD4 Fusion Protein Ag16099 (114-463 aa encoded by BC109272)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RRRWVTPAG RPDFDHLLRT YGDVVVPVAN CGVQEYNSNP KEHMTLRDYI TYWKEYIQAG YSSPRGCLYL KDWHLCRDFP VEDVFTLPVY FSSDWLNEFW DALDVDDYRF VYAGPAGSWS PFHADIFRSF SWSVNVCGRK KWLLFPPGQE EALRDRHGNL PYDVTSPALC DTHLHPRNQL AGPPLEITQE AGEMVFVPSG WHHQVHNLDD TISINHNWVN GFNLANMWRL LQQELCAVQE EVSEWRDSMP DWHHHCQVIM RSCSGINFEE FYHFLKVIAE KRLLVLREAA AEDGAGLGFE QAAFDVGRIT EVLASLVAHP DFQRVDTSAF SPQPKELLQQ LREAVDAAAA P (114-463 aa encoded by BC109272)
Target Information
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-oxoglutarate and iron-dependent oxygenase JMJD4; 2-oxoglutarate- and Fe(II)-dependent oxygenase; C4 lysyl hydroxylase; JmjC domain-containing protein 4; Jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4
Gene Aliases: JMJD4
UniProt ID: (Human) Q9H9V9
Entrez Gene ID: (Human) 65094
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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