Proteintech

JMJD6 Polyclonal Antibody

JMJD6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

JMJD6 Antibody (16476-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart using 16476-1-AP (JMJD6 antibody) at dilution of 1:50 (under 40x lens).

JMJD6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16476-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

ChIP assay (ChIP)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

JMJD6 Fusion Protein Ag9590 (1-403 aa encoded by BC066654)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNHKSKKRI REAKRSARPE LKDSLDWTRH NYYESFSLSP AAVADNVERA DALQLSVEEF VERYERPYKP VVLLNAQEGW SAQEKWTLER LKRKYRNQKF KCGEDNDGYS VKMKMKYYIE YMESTRDDSP LYIFDSSYGE HPKRRKLLED YKVPKFFTDD LFQYAGEKRR PPYRWFVMGP PRSGTGIHID PLGTSAWNAL VQGHKRWCLF PTSTPRELIK VTRDEGGNQQ DEAITWFNVI YPRTQLPTWP PEFKPLEILQ KPGETVFVPG GWWHVVLNLD TTIAITQNFA SSTNFPVVWH KTVRGRPKLS RKWYRILKQE HPELAVLADS VDLQESTGIA SDSSSDSSSS SSSSSSDSDS ECESGSEGDG TVHRRKKRRT CSMVGNGDTT SQDDCVSKER SSSR (1-403 aa encoded by BC066654)

Target Information

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.

Acta pharmacologica Sinica

Guo Z,Hu YH,Feng GS,Valenzuela Ripoll C,Li ZZ,Cai SD,Wang QQ,Luo WW,Li Q,Liang LY,Wu ZK,Zhang JG,Javaheri A,Wang L,Lu J,Liu PQ

Fri Sep 01 00:00:00 UTC 2023

JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.

Acta pharmacologica Sinica

Guo Z,Hu YH,Feng GS,Valenzuela Ripoll C,Li ZZ,Cai SD,Wang QQ,Luo WW,Li Q,Liang LY,Wu ZK,Zhang JG,Javaheri A,Wang L,Lu J,Liu PQ

Fri Sep 01 00:00:00 UTC 2023

JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.

Acta pharmacologica Sinica

Guo Z,Hu YH,Feng GS,Valenzuela Ripoll C,Li ZZ,Cai SD,Wang QQ,Luo WW,Li Q,Liang LY,Wu ZK,Zhang JG,Javaheri A,Wang L,Lu J,Liu PQ

Fri Sep 01 00:00:00 UTC 2023

JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.

Acta pharmacologica Sinica

Guo Z,Hu YH,Feng GS,Valenzuela Ripoll C,Li ZZ,Cai SD,Wang QQ,Luo WW,Li Q,Liang LY,Wu ZK,Zhang JG,Javaheri A,Wang L,Lu J,Liu PQ

Fri Sep 01 00:00:00 UTC 2023

c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway.

Cell biology international

Liu Y,Sui A,Sun J,Wu Y,Liu F,Yang Y

Tue Aug 01 00:00:00 UTC 2023

Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer.

Journal of medicinal chemistry

Li J,Liu T,Song Y,Wang M,Liu L,Zhu H,Li Q,Lin J,Jiang H,Chen K,Zhao K,Wang M,Zhou H,Lin H,Luo C

Thu Aug 25 00:00:00 UTC 2022

JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.

PLoS pathogens

Zhang W,Wang Q,Yang F,Zhu Z,Duan Y,Yang Y,Cao W,Zhang K,Ma J,Liu X,Zheng H

Mon Mar 01 00:00:00 UTC 2021

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.

Molecular cell