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Invitrogen
JWA Polyclonal Antibody
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JWA Antibody (PA5-18094) in ICC/IF
Immunocytochemistry analysis of JWA using JWA Polyclonal Antibody (Product # PA5-18094) in paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing plasma membrane and ER/cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Product Details
PA5-18094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (NRLTDYISKVKE) corresponding to the C-terminus amino acids of ARL6IP5 (aa 177-188).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10989136
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
JWA protein expression is affected by vitamin A and may be associated with the cytoskeleton. A protein similar to JWA in rats may play a role in the regulation of cell differentiation by inhibiting the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factor GTPase 6 interacting protein 5; ADP-ribosylation factor like GTPase 6 interacting protein 5; ADP-ribosylation factor-like 6 interacting protein 5; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; aip-5; ARL-6-interacting protein 5; cytoskeleton related vitamin A responsive protein; Cytoskeleton-related vitamin A-responsive protein; dermal papilla derived protein 11; Dermal papilla-derived protein 11; Glutamate transporter EAAC1-interacting protein; glutamate transporter EEAC1-associated protein; GTRAP3-18; JM5; PRA1 domain family 3; PRA1 family protein 3; Prenylated Rab acceptor protein 2; Protein JWa; putative MAPK activating protein PM27; Putative MAPK-activating protein PM27
Gene Aliases: addicsin; ARL6IP5; DERP11; GTRAP3-18; hp22; HSPC127; jmx; JWA; PRA2; PRAF3; Yip6b
UniProt ID: (Human) O75915
Entrez Gene ID: (Human) 10550
negative regulation of L-glutamate transport
intrinsic apoptotic signaling pathway in response to oxidative stress
negative regulation of mitochondrial membrane potential
L-glutamate transport
positive regulation of stress-activated MAPK cascade
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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