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Product Details
PA5-71372
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human JWA
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2690903
Target Information
JWA protein expression is affected by vitamin A and may be associated with the cytoskeleton. A protein similar to JWA in rats may play a role in the regulation of cell differentiation by inhibiting the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Addicsin; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; Glutamate transporter EAAC1-interacting protein; GTRAP3-18; PRA1 family protein 3; Prenylated Rab acceptor protein 2; Protein JWa
Gene Aliases: 5930404D22Rik; addiscin; Aip-5; Aip5; Arl6ip5; AV001879; Gtrap3-18; Jwa; Pra2; Praf3
UniProt ID: (Mouse) Q8R5J9
Entrez Gene ID: (Mouse) 65106
intrinsic apoptotic signaling pathway in response to oxidative stress
negative regulation of mitochondrial membrane potential
L-glutamate transport
positive regulation of stress-activated MAPK cascade
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of transport
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