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Invitrogen
JunD Polyclonal Antibody
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FIGURE: 1 / 1
JunD Antibody (PA5-120140) in WB
Western blot analysis of JunD in extracts of various cell lines. Samples were incubated with JunD Polyclonal antibody (Product # PA5-120140) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-120140
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human JunD (NP_005345.3).
Conjugate
Form
Liquid
Concentration
2.43 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913712
Product Specific Information
Positive test controls include: HeLa, Jurkat, 293T, HepG2, Mouse kidney, Mouse liver, Mouse pancreas, Mouse testis, Rat liver. The target is usually found in the following locations: Nucleus.
Immunogen sequence: METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL TLSLSEQVAA ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ NQLGAGAAAA AAAAAAGGPS GTATGSAPPG ELAPAAAAPE
Target Information
JunD is a transcription factor which is coded by JunD gene. JunD transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) family of protein kinase. Jun proteins are capable of forming dimers with Fos, ATF and CREB family transcription factors to form the AP-1 complex that differentially regulates a variety of target genes involved in cellular growth, proliferation, differentiation and apoptosis. Also, JunD plays an important role in metabolism via modulation of IGF-1 signaling pathway.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activator protein 1; AP1; JUN D; jun D proto-oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; JunD-FL isoform; Oncogene Jun-D; Transcription factor AP-1 subunit JunD; transcription factor jun-D; Transcription factor JunD
Gene Aliases: AP-1; Jun-d; JUND; Jund1
UniProt ID: (Human) P17535, (Rat) P52909, (Mouse) P15066
Entrez Gene ID: (Human) 3727, (Rat) 24518, (Mouse) 16478
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
enzyme binding
transcription regulatory region DNA binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein heterodimerization activity
osteoblast development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
aging
circadian rhythm
response to light stimulus
response to mechanical stimulus
response to organic cyclic compound
response to lipopolysaccharide
response to peptide hormone
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to calcium ion
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
response to radiation
regulation of cell death
cellular response to hormone stimulus
response to cytokine
regulation of cell proliferation
response to drug
positive regulation of cell differentiation
response to cAMP
regulation of cell cycle
transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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