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Invitrogen
Junin mammarenavirus Nucleoprotein Polyclonal Antibody
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Junin mammarenavirus Nucleoprotein Antibody (PA5-117554) in WB
Western Blot analysis of Junin mammarenavirus Nucleoprotein using Junin mammarenavirus Nucleoprotein Polyclonal Antibody (Product # PA5-117554) at 3 µg/mL. Positive WB detected in Recombinant protein. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 64 kDa. Observed band size: 64 kDa
Product Details
PA5-117554
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Junin mammarenavirus Nucleoprotein protein (1-564aa)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2902183
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation. Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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