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KAL1 Antibody (MA5-27048) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human embryonic cerebellum tissue. To expose target proteins, heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min. Following antigen retrieval, tissues were probed with a KAL1 monoclonal antibody (Product # MA5-27048) at a dilution of 1:500.
Product Details
MA5-27048
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI5E10
Immunogen
Human recombinant protein fragment corresponding to amino acids 129-373 of KAL1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724542
Target Information
KAL1 (Anosmin-1) an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adhesion molecule-like X-linked; anosmin; Anosmin-1; Anosmin1; Kallmann syndrome interval gene 1; Kallmann syndrome protein; Kallmann syndrome-1 sequence (anosmin-1); WAP four-disulfide core domain 19
Gene Aliases: ADMLX; ANOS1; HH1; HHA; KAL; KAL1; KALIG-1; KALIG1; KMS; WFDC19
UniProt ID: (Human) P23352
Entrez Gene ID: (Human) 3730
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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