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Invitrogen
KANK1 Polyclonal Antibody
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Product Details
PA5-34533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the amino terminus of human KANK1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551885
Product Specific Information
A suggested positive control is NIH-3T3 cell lysate.
PA5-34533 can be used with blocking peptide PEP-1576.
Target Information
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin repeat domain 15; Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; KN motif and ankyrin repeat domains 1
Gene Aliases: A930031B09Rik; ANKRD15; AU015049; AW121052; CPSQ2; D330024H06Rik; KANK; KANK1; KIAA0172; mKIAA0172
UniProt ID: (Human) Q14678, (Mouse) E9Q238
Entrez Gene ID: (Human) 23189, (Mouse) 107351
negative regulation of neuron projection development
positive regulation of Wnt signaling pathway
negative regulation of cell migration
negative regulation of actin filament polymerization
negative regulation of Rho protein signal transduction
positive regulation of catenin import into nucleus
negative regulation of insulin receptor signaling pathway
positive regulation of wound healing
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
regulation of establishment of cell polarity
negative regulation of lamellipodium morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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