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Invitrogen
KANK2 Polyclonal Antibody
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Product Details
PA5-53357
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KANK2. Recombinant protein control fragment (Product #RP-90786).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642868
Product Specific Information
Immunogen sequence: SQHIPTAEGA SGSNTEEEIR MELSPDLISA CLALEKYLDN PNALTERELK VAYTTVLQEW LRLACRSDAH PELVRRHLVT FRAMSARLLD YVVNIADSNG NTALHYSVSH ANFPVVQ
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
Target Information
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ankyrin repeat domain-containing protein 25; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; Matrix-remodeling-associated protein 3; SIP; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein
Gene Aliases: ANKRD25; KANK2; KIAA1518; MXRA3; PPKWH; SIP
UniProt ID: (Human) Q63ZY3
Entrez Gene ID: (Human) 25959
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
negative regulation of cell proliferation
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of programmed cell death
negative regulation of vitamin D receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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