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Product Details
MA5-35678
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1S7J7
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 675-792 of human KIFAP3 (Q92845)
Conjugate
Form
Liquid
Concentration
0.61 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849578
Product Specific Information
Immunogen sequence: KFRWHNSQWL EMVESRQMDE SEQYLYGDDR IEPYIHEGDI LERPDLFYNS DGLIASEGAI SPDFFNDYHL QNGDVVGQHS FPGSLGMDGF GQPVGILGRP ATAYGFRPDE PYYYGYGS
Target Information
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KAP-3; Kinesin-associated protein 3; small G protein GDP dissociation stimulator; Smg GDS-associated protein
Gene Aliases: dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; KIF3AP; KIFAP3; SMAP; Smg-GDS
UniProt ID: (Human) Q92845, (Mouse) P70188
Entrez Gene ID: (Human) 22920, (Rat) 289168, (Mouse) 16579
microtubule-based process
protein localization
negative regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of calcium-dependent cell-cell adhesion
protein complex assembly
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
signal transduction
antigen processing and presentation of exogenous peptide antigen via MHC class II
plus-end-directed vesicle transport along microtubule
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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