Proteintech

KAT5 Polyclonal Antibody

KAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KAT5 Antibody (10827-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 10827-1-AP (KAT5 antibody) at dilution of 1:100 (under 10x lens).

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Product Details

10827-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KAT5 Fusion Protein Ag1261 (101-457 aa encoded by BC000166)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ATPVPSETA PASVFPQNGA ARRAVAAQPG RKRKSNCLGT DEDSQDSSDG IPSAPRMTGS LVSDRSHDDI VTRMKNIECI ELGRHRLKPW YFSPYPQELT TLPVLYLCEF CLKYGRSLKC LQRHLTKCDL RHPPGNEIYR KGTISFFEID GRKNKSYSQN LCLLAKCFLD HKTLYYDTDP FLFYVMTEYD CKGFHIVGYF SKEKESTEDY NVACILTLPP YQRRGYGKLL IEFSYELSKV EGKTGTPEKP LSDLGLLSYR SYWSQTILEI LMGLKSESGE RPQITINEIS EITSIKKEDV ISTLQYLNLI NYYKGQYILT LSEDIVDGHE RAMLKRLLRI DSKCLHFTPK DWSKRGKW (101-457 aa encoded by BC000166)

Target Information

TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.

Science advances

Jia M,Yue X,Sun W,Zhou Q,Chang C,Gong W,Feng J,Li X,Zhan R,Mo K,Zhang L,Qian Y,Sun Y,Wang A,Zou Y,Chen W,Li Y,Huang L,Yang Y,Zhao Y,Cheng X

Fri Jun 02 00:00:00 UTC 2023

A NPAS4-NuA4 complex couples synaptic activity to DNA repair.

Nature

Pollina EA,Gilliam DT,Landau AT,Lin C,Pajarillo N,Davis CP,Harmin DA,Yap EL,Vogel IR,Griffith EC,Nagy MA,Ling E,Duffy EE,Sabatini BL,Weitz CJ,Greenberg ME

Wed Feb 01 00:00:00 UTC 2023

Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin.

Cell

Zhu Y,Hart GW

Thu Jan 19 00:00:00 UTC 2023

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis.

Journal of molecular cell biology

Akbar H,Cao J,Wang D,Yuan X,Zhang M,Muthusamy S,Song X,Liu X,Aikhionbare F,Yao X,Gao X,Liu X

Mon Dec 26 00:00:00 UTC 2022

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis.

Journal of molecular cell biology

Akbar H,Cao J,Wang D,Yuan X,Zhang M,Muthusamy S,Song X,Liu X,Aikhionbare F,Yao X,Gao X,Liu X

Mon Dec 26 00:00:00 UTC 2022

Acquired temozolomide resistance in MGMT^low gliomas is associated with regulation of homologous recombination repair by ROCK2.

Cell death & disease

Zhang X,Li T,Yang M,Du Q,Wang R,Fu B,Tan Y,Cao M,Chen Y,Wang Q,Hu R

Thu Feb 10 00:00:00 UTC 2022

Acquired temozolomide resistance in MGMT^low gliomas is associated with regulation of homologous recombination repair by ROCK2.

Cell death & disease

Zhang X,Li T,Yang M,Du Q,Wang R,Fu B,Tan Y,Cao M,Chen Y,Wang Q,Hu R

Thu Feb 10 00:00:00 UTC 2022

Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival.

Cancers

Zhang X,Bustos MA,Shoji Y,Ramos RI,Iida Y,Gentry R,Takeshima TL,Hoon DSB

Sat Sep 18 00:00:00 UTC 2021

DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation.

iScience

Hishikawa A,Hayashi K,Kubo A,Miyashita K,Hashiguchi A,Kinouchi K,Yoshimoto N,Nakamichi R,Akashio R,Sugita E,Azegami T,Monkawa T,Suematsu M,Itoh H

Fri Dec 17 00:00:00 UTC 2021

Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility.

Human reproduction (Oxford, England)

Cheng YM,Peng Z,Chen HY,Pan TT,Hu XN,Wang F,Luo T

Fri Mar 27 00:00:00 UTC 2020

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.

Nature communications

You Z,Jiang WX,Qin LY,Gong Z,Wan W,Li J,Wang Y,Zhang H,Peng C,Zhou T,Tang C,Liu W

Thu Dec 19 00:00:00 UTC 2019

Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.

Frontiers in pediatrics

Wang J,Liu H,Gao L,Liu X

Sun Nov 12 00:00:00 UTC 2023

Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.

Frontiers in pediatrics

Wang J,Liu H,Gao L,Liu X

Sun Nov 12 00:00:00 UTC 2023

Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhang Y,Ji G,Han S,Shao Z,Lu Z,Huo L,Zhang J,Yang R,Feng Q,Shen H,Wang H,Li X

Fri Nov 02 00:00:00 UTC 2018

Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zhang Y,Ji G,Han S,Shao Z,Lu Z,Huo L,Zhang J,Yang R,Feng Q,Shen H,Wang H,Li X

Fri Nov 02 00:00:00 UTC 2018

The transcriptional coactivator TAZ regulates reciprocal differentiation of T_H17 cells and T_reg cells.

Nature immunology

Geng J,Yu S,Zhao H,Sun X,Li X,Wang P,Xiong X,Hong L,Xie C,Gao J,Shi Y,Peng J,Johnson RL,Xiao N,Lu L,Han J,Zhou D,Chen L

Sat Jul 01 00:00:00 UTC 2017

The transcriptional coactivator TAZ regulates reciprocal differentiation of T_H17 cells and T_reg cells.

Nature immunology

Geng J,Yu S,Zhao H,Sun X,Li X,Wang P,Xiong X,Hong L,Xie C,Gao J,Shi Y,Peng J,Johnson RL,Xiao N,Lu L,Han J,Zhou D,Chen L

Sat Jul 01 00:00:00 UTC 2017

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Molecular cell

Barral S,Morozumi Y,Tanaka H,Montellier E,Govin J,de Dieuleveult M,Charbonnier G,Couté Y,Puthier D,Buchou T,Boussouar F,Urahama T,Fenaille F,Curtet S,Héry P,Fernandez-Nunez N,Shiota H,Gérard M,Rousseaux S,Kurumizaka H,Khochbin S

Thu Apr 06 00:00:00 UTC 2017

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Molecular cell

Thu Apr 06 00:00:00 UTC 2017

MDR1 mediated chemoresistance: BMI1 and TIP60 in action.

Biochimica et biophysica acta

Banerjee Mustafi S,Chakraborty PK,Naz S,Dwivedi SK,Street M,Basak R,Yang D,Ding K,Mukherjee P,Bhattacharya R

Mon Aug 01 00:00:00 UTC 2016

MDR1 mediated chemoresistance: BMI1 and TIP60 in action.

Biochimica et biophysica acta

Banerjee Mustafi S,Chakraborty PK,Naz S,Dwivedi SK,Street M,Basak R,Yang D,Ding K,Mukherjee P,Bhattacharya R

Mon Aug 01 00:00:00 UTC 2016

Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).

Molecular & cellular proteomics : MCP

Yu H,Diao H,Wang C,Lin Y,Yu F,Lu H,Xu W,Li Z,Shi H,Zhao S,Zhou Y,Zhang Y

Wed Apr 01 00:00:00 UTC 2015

Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).

Molecular & cellular proteomics : MCP

Yu H,Diao H,Wang C,Lin Y,Yu F,Lu H,Xu W,Li Z,Shi H,Zhao S,Zhou Y,Zhang Y

Wed Apr 01 00:00:00 UTC 2015

ANP32E is a histone chaperone that removes H2A.Z from chromatin.

Nature

Obri A,Ouararhni K,Papin C,Diebold ML,Padmanabhan K,Marek M,Stoll I,Roy L,Reilly PT,Mak TW,Dimitrov S,Romier C,Hamiche A

Thu Jan 30 00:00:00 UTC 2014

ANP32E is a histone chaperone that removes H2A.Z from chromatin.

Nature

Obri A,Ouararhni K,Papin C,Diebold ML,Padmanabhan K,Marek M,Stoll I,Roy L,Reilly PT,Mak TW,Dimitrov S,Romier C,Hamiche A

Thu Jan 30 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2 interacting protein; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein 60 kD; HIV-1 Tat interactive protein, 60 kD; HIV-1 Tat interactive protein, 60kDa; HIV-1 tat interactive protein, homolog; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tat interacting protein, 60kDa; Tat-interactive protein-60; Tip60; TIP60(HTATIP)

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Gene Aliases: AI839539; CPLA2; ESA1; HTATIP; HTATIP1; KAT5; PLIP; TIP; Tip55; TIP60; Tip60b; ZC2HC5

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UniProt ID: (Human) Q92993, (Mouse) Q8CHK4, (Rat) Q99MK2

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Entrez Gene ID: (Human) 10524, (Mouse) 81601, (Rat) 192218

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Function(s)

transcription coactivator activity histone acetyltransferase activity protein binding acetyltransferase activity metal ion binding androgen receptor binding repressing transcription factor binding chromatin binding transcription factor binding transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups protein complex binding phospholipase binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter double-strand break repair transcription, DNA-templated regulation of transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator response to ionizing radiation chromatin modification histone acetylation negative regulation of interleukin-2 production regulation of growth proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cellular response to estradiol stimulus positive regulation of protein acetylation apoptotic process response to heat histone H4 acetylation cellular response to hydrogen peroxide cellular response to X-ray DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement DNA replication double-strand break repair via nonhomologous end joining viral process androgen receptor signaling pathway regulation of signal transduction by p53 class mediator beta-catenin-TCF complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KAT5 Polyclonal Antibody

KAT5 Antibody (10827-1-AP) in IHC (P)

Product Details

10827-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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