Proteintech

KATNB1 Polyclonal Antibody

KATNB1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

KATNB1 Antibody (14969-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 14969-1-AP (KATNB1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

KATNB1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14969-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KATNB1 Fusion Protein Ag6836 (305-655 aa encoded by BC001353)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VTRTGTVAR DPVQDHRPLA QPLPNPSAPL RRIYERPSTT CSKPQRVKQN SESERRSPSS EDDRDERESR AEIQNAEDYN EIFQPKNSIS RTPPRRSEPF PAPPEDDAAT AKEAAKPSPA MDVQFPVPNL EVLPRPPVVA STPAPKAEPA IIPATRNEPI GLKASDFLPA VKIPQQAELV DEDAMSQIRK GHDTMCVVLT SRHKNLDTVR AVWTMGDIKT SVDSAVAIND LSVVVDLLNI VNQKASLWKL DLCTTVLPQI EKLLQSKYES YVQTGCTSLK LILQRFLPLI TDMLAAPPSV GVDISREERL HKCRLCYKQL KSISGLVKSK SGLSGRHGST FRELHLLMAS LD (305-655 aa encoded by BC001353)

Target Information

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals.

Cell reports

Almeida AC,Soares-de-Oliveira J,Drpic D,Cheeseman LP,Damas J,Lewin HA,Larkin DM,Aguiar P,Pereira AJ,Maiato H

Tue Apr 05 00:00:00 UTC 2022

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.

The Journal of cell biology

Huang J,Liang Z,Guan C,Hua S,Jiang K

Mon Aug 02 00:00:00 UTC 2021

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.

The Journal of cell biology

Huang J,Liang Z,Guan C,Hua S,Jiang K

Mon Aug 02 00:00:00 UTC 2021

The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.

Molecular biology of the cell

Stemm-Wolf AJ,O'Toole ET,Sheridan RM,Morgan JT,Pearson CG

Fri Oct 01 00:00:00 UTC 2021

WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation.

The Journal of cell biology

Guerreiro A,De Sousa F,Liaudet N,Ivanova D,Eskat A,Meraldi P

Mon Aug 02 00:00:00 UTC 2021

WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation.

The Journal of cell biology

Guerreiro A,De Sousa F,Liaudet N,Ivanova D,Eskat A,Meraldi P

Mon Aug 02 00:00:00 UTC 2021

Klebsiella pneumoniae Redistributes Katanin Severing Proteins and Alters Astral Microtubules during Mitosis.

Anatomical record (Hoboken, N.J. : 2007)

Chua MD,Bogdan AC,Guttman JA

Wed Jul 01 00:00:00 UTC 2020

Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells.

Cellular microbiology

Chua MD,Liou CH,Bogdan AC,Law HT,Yeh KM,Lin JC,Siu LK,Guttman JA

Fri Mar 01 00:00:00 UTC 2019

Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells.

Cellular microbiology

Chua MD,Liou CH,Bogdan AC,Law HT,Yeh KM,Lin JC,Siu LK,Guttman JA

Fri Mar 01 00:00:00 UTC 2019

Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.

European journal of medicinal chemistry

Gao F,Liang Y,Zhou P,Cheng J,Ding K,Wang Y

Sun Sep 15 00:00:00 UTC 2019

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure (London, England : 1993)

Jiang K,Faltova L,Hua S,Capitani G,Prota AE,Landgraf C,Volkmer R,Kammerer RA,Steinmetz MO,Akhmanova A

Tue Mar 06 00:00:00 UTC 2018

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure (London, England : 1993)

Jiang K,Faltova L,Hua S,Capitani G,Prota AE,Landgraf C,Volkmer R,Kammerer RA,Steinmetz MO,Akhmanova A

Tue Mar 06 00:00:00 UTC 2018

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Hu WF,Pomp O,Ben-Omran T,Kodani A,Henke K,Mochida GH,Yu TW,Woodworth MB,Bonnard C,Raj GS,Tan TT,Hamamy H,Masri A,Shboul M,Al Saffar M,Partlow JN,Al-Dosari M,Alazami A,Alowain M,Alkuraya FS,Reiter JF,Harris MP,Reversade B,Walsh CA

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Developmental cell

Jiang K,Hua S,Mohan R,Grigoriev I,Yau KW,Liu Q,Katrukha EA,Altelaar AF,Heck AJ,Hoogenraad CC,Akhmanova A

Mon Feb 10 00:00:00 UTC 2014

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Developmental cell

Jiang K,Hua S,Mohan R,Grigoriev I,Yau KW,Liu Q,Katrukha EA,Altelaar AF,Heck AJ,Hoogenraad CC,Akhmanova A

Mon Feb 10 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: katanin (80 kDa); katanin p80 (WD repeat containing) subunit B 1; katanin p80 (WD40-containing) subunit B 1; Katanin p80 subunit B1; Katanin p80 WD40 repeat-containing subunit B1; katanin p80 WD40-containing subunit B1; KATNB1; p80 katanin

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Gene Aliases: 2410003J24Rik; KAT; KATNB1; LIS6

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UniProt ID: (Human) Q9BVA0, (Mouse) Q8BG40

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Entrez Gene ID: (Human) 10300, (Mouse) 74187, (Rat) 291852

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Function(s)

microtubule binding microtubule-severing ATPase activity dynein binding protein heterodimerization activity protein binding

Process(es)

negative regulation of microtubule depolymerization cell cycle mitotic nuclear division metabolic process positive regulation of cell death positive regulation of neuron projection development positive regulation of microtubule depolymerization microtubule severing cell division mitotic chromosome movement towards spindle pole protein targeting

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KATNB1 Polyclonal Antibody

KATNB1 Antibody (14969-1-AP) in ICC/IF

Product Details

14969-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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