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Product Details
18103-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNA10 Fusion Protein Ag12434 (1-216 aa encoded by BC074990)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDVCGWKEM EVALVNFDNS DEIQEEPGYA TDFDSTSPKG RPGGSSFSNG KILISESTNH ETAFSKLPGD YADPPGPEPV VLNEGNQRVI INIAGLRFET QLRTLSQFPE TLLGDREKRM QFFDSMRNEY FFDRNRPSFD GILYYYQSGG KIRRPANVPI DIFADEISFY ELGSEAMDQF REDEGFIKDP ETLLPTNDIH RQFWLLFEYP ESSSAAR (1-216 aa encoded by BC074990)
Target Information
KCNA10 is a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclic GMP gated potassium channel; potassium channel, voltage gated shaker related subfamily A, member 10; potassium voltage gated channel, shaker related subfamily, member 8; Potassium voltage-gated channel subfamily A member 10; potassium voltage-gated channel, shaker-related subfamily, member 10; potassium voltage-gated channel, shaker-related subfamily, member 8; Voltage-gated potassium channel subunit Kv1.8
Gene Aliases: Gm1962; Kcn1; KCNA10; Kcna8; Kv1.8
UniProt ID: (Human) Q16322, (Mouse) B2RQA1
Entrez Gene ID: (Human) 3744, (Rat) 295360, (Mouse) 242151
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