Proteintech

KCNAB2 Polyclonal Antibody

4 References
View all (8) KVbeta2 (KCNAB2) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

17890-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 3 publications 3 publications

Immunohistochemistry (IHC)

Assay-dependent
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KCNAB2 Fusion Protein Ag12096 (1-395 aa encoded by BC110351)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MYPESTTGS PARLSLRQTG SPGMIYSTRY GSPKRQLQFY RNLGKSGLRV SCLGLGTWVT FGGQITDEMA EQLMTLAYDN GINLFDTAEV YAAGKAEVVL GNIIKKKGWR RSSLVITTKI FWGGKAETER GLSRKHIIEG LKASLERLQL EYVDVVFANR PDPNTPMEET VRAMTHVINQ GMAMYWGTSR WSSMEIMEAY SVARQFNLTP PICEQAEYHM FQREKVEVQL PELFHKIGVG AMTWSPLACG IVSGKYDSGI PPYSRASLKG YQWLKDKILS EEGRRQQAKL KELQAIAERL GCTLPQLAIA WCLRNEGVSS VLLGASNADQ LMENIGAIQV RVRGPAGQRA HPSPSPVQCI LPGSSCVPGS VLGTQDAPVN HQSCAPGELA FQQEQT (1-395 aa encoded by B C110351)

Target Information

Kcnab2 is a voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: hKvbeta2; K(+) channel subunit beta-2; Kv-beta-2; Kvbeta2; Neuroimmune protein F5; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; Voltage-gated potassium channel subunit beta-2

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Gene Aliases: AKR6A5; Ckbeta2; F5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; I2rf5; KCNA2B; KCNAB2; Kcnb3; KCNK2; KV-BETA-2

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UniProt ID: (Human) Q13303, (Mouse) P62482, (Rat) P62483

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Entrez Gene ID: (Human) 8514, (Mouse) 16498, (Rat) 29738

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Function(s)
aldo-keto reductase (NADP) activity voltage-gated potassium channel activity potassium channel regulator activity C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity isocitrate dehydrogenase activity mevaldate reductase activity voltage-gated ion channel activity protein binding gluconate dehydrogenase activity steroid dehydrogenase activity oxidoreductase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity ion channel binding 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
Process(es)
hematopoietic progenitor cell differentiation neuromuscular process oxidation-reduction process NADPH oxidation potassium ion transmembrane transport regulation of potassium ion transmembrane transport regulation of protein localization to cell surface transport ion transport potassium ion transport regulation of ion transmembrane transport protein heterooligomerization
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