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Invitrogen
KCNAB3 Polyclonal Antibody
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FIGURE: 1 / 3
KCNAB3 Antibody (PA5-36970) in IHC (P)
Immunohistochemistry analysis of KCNAB3 in paraffin-embedded human breast carcinoma tissue (cell membrane staining) and negative control (right, with PBS only). Samples were incubated with KCNAB3 polyclonal antibody (Product # PA5-36970) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-36970
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 337-382 of human KV beta3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553840
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 44 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV beta.3 is an accessory K+ channel protein which regulates the activity of the pore-forming alpha subunit and alters the functional properties of Kv1.5. KV beta.3 localizes to the cytoplasm and is expressed in the brain, with highest expression detected in the cerebellum, and weakest expression seen in the frontal and temporal lobes. No KV beta.3 expression is detected in the heart, spinal cord, lung, liver, kidney, pancreas, placenta or skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: K(+) channel subunit beta-3; Kv-beta-3; KV-beta.3; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium voltage gated channel, shaker related subfamily, beta member 3; potassium voltage-gated channel, shaker-related subfamily, beta member 3; RCK beta3; Voltage-gated potassium channel subunit beta-3
Gene Aliases: AKR6A9; C330022D06Rik; Ckbeta3; KCNA3.1B; KCNA3B; KCNAB3; Kcnab4; KV-BETA-3; mKv(beta)4
UniProt ID: (Human) O43448, (Rat) Q63494
Entrez Gene ID: (Human) 9196, (Rat) 58981, (Mouse) 16499
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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