Proteintech

KCNE1 Polyclonal Antibody

2 References
View all (10) KCNE1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

15150-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KCNE1 Fusion Protein Ag3495 (1-106 aa encoded by BC036452)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MILSNTTAV TPFLTKLWQE TVQQGGNMSG LAHRSPRSGD GKLEALYVLM VLGFFGFFTL GIMLSYIRSK KLEHSNDPFN VYIESDAWQE KDKAYVQARV LESYRS (1-106 aa encoded by B C036452)

Target Information

Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; JLNS 2; KCNE 1; KCNE1 (IsK); LQT 5; MGC33114; Minimal potassium channel; MinK; mISK; potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit

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Gene Aliases: ISK; JLNS; JLNS2; KCNE1; LQT2/5; LQT5; m; MinK; nmf190

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UniProt ID: (Human) P15382, (Mouse) P23299, (Rat) P15383

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Entrez Gene ID: (Human) 3753, (Mouse) 16509, (Rat) 25471

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Function(s)
voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding potassium channel regulator activity telethonin binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization voltage-gated ion channel activity potassium channel activity ion channel binding protein heterodimerization activity
Process(es)
protein N-linked glycosylation protein O-linked glycosylation sensory perception of sound regulation of ventricular cardiac muscle cell membrane repolarization cardiac conduction cellular response to cAMP potassium ion export potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction ventricular cardiac muscle cell action potential membrane repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction negative regulation of protein targeting to membrane membrane repolarization during ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity epithelial cell maturation transport ion transport potassium ion transport regulation of ion transmembrane transport heart contraction regulation of membrane repolarization cellular response to acidic pH positive regulation of voltage-gated calcium channel activity negative regulation of voltage-gated potassium channel activity male gonad development
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