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Alomone Labs, LTD
KCNMA1 (KCa1.1) (1097-1196) Polyclonal Antibody
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FIGURE: 1 / 3
KCNMA1 (KCa1.1) (1097-1196) Antibody (APC-021-GP200UL) in WB
Western blot analysis of human Colo205 colon adenocarcinoma (lanes 1 and 3) and human Caco-2 colon adenocarcinoma cell lysates (lanes 2 and 4): - 1,2.Guinea pig Anti-KCNMA1 (KCa1.1) (1097–1096) Antibody (#APC-021-GP), (1:200).3,4. Guinea pig Anti-KCNMA1 (KCa1.1) (1097–1096) Antibody , preincubated with KCNMA1/KCa1.1 (1097-1196) Blocking Peptide (#BLP-PC021).
Product Details
APC-021-GP200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GST fusion protein with the sequence corresponding to residues 1097-1196 of mouse KCNMA1 variant 2, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: SHSSHSSQSS SKKSSSVHSI PSTANRPNRP KSRESRDKQN ATRMTRMGQA EKKWFTDEPD NAYPRNIQIK PMSTHMANQI NQYKSTSSLI PPIREVEDEC
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; maxi-K channel HSLO; MaxiK; mSlo1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; stretch-activated Kca channel
Gene Aliases: 5730414M22Rik; bA205K10.1; BKCa; BKTM; hSlo; KCa1.1; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
UniProt ID: (Human) Q12791, (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Human) 3778, (Mouse) 16531, (Rat) 83731
actin binding
voltage-gated potassium channel activity
protein binding
calcium-activated potassium channel activity
metal ion binding
large conductance calcium-activated potassium channel activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
protein complex binding
protein homodimerization activity
response to hypoxia
potassium ion transport
response to osmotic stress
cellular potassium ion homeostasis
response to carbon monoxide
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of apoptotic process
negative regulation of cell volume
response to calcium ion
micturition
smooth muscle contraction involved in micturition
potassium ion transmembrane transport
transport
ion transport
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
response to pH
neuronal action potential
response to corticosteroid
regulation of aldosterone metabolic process
vasodilation
regulation of vasodilation
auditory receptor cell differentiation
response to estrogen
locomotor rhythm
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
protein homotetramerization
transmembrane transport
eye blink reflex
relaxation of vascular smooth muscle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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