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Product Details
17929-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNN1 Fusion Protein Ag12357 (366-543 aa encoded by BC075037)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL IYKHTRLVKK PDQARVRKHQ RKFLQAIHQA QKLRSVKIEQ GKLNDQANTL TDLAKTQTVM YDLVSELHAQ HEELEARLAT LESRLDALGA SLQALPGLIA QAIRPPPPPL PPRPGPGPQD QAARSSPCRW TPVAPSDCG (366-543 aa encoded by BC075037)
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like; SK1; SKCa 1; SKCa1; small conductance calcium-activated potassium channel 1; Small conductance calcium-activated potassium channel protein 1
Gene Aliases: AI854248; hSK1; KCa2.1; KCNN1; SK; SK1; SKCA1
UniProt ID: (Human) Q92952, (Rat) P70606, (Mouse) Q9EQR3
Entrez Gene ID: (Human) 3780, (Rat) 54261, (Mouse) 84036
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