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Invitrogen
KCNN1 Polyclonal Antibody
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KCNN1 Antibody (PA5-97206) in WB
Western blot analysis of KCNN1 in extracts of various cell lines. Samples were incubated with KCNN1 Polyclonal antibody (Product # PA5-97206) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-97206
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNN1 (NP_0022392)
Conjugate
Form
Liquid
Concentration
1.85 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2809008
Product Specific Information
Immunogen sequence: MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG; Positive Samples: U-87MG, SH-SY5Y, Jurkat, Mouse brain, Mouse heart; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; SK1; SKCa 1; SKCa1; small conductance calcium-activated potassium channel 1; Small conductance calcium-activated potassium channel protein 1
Gene Aliases: AI854248; hSK1; KCa2.1; KCNN1; SK; SK1; SKCA1
UniProt ID: (Human) Q92952, (Mouse) Q9EQR3
Entrez Gene ID: (Human) 3780, (Mouse) 84036
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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