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Invitrogen
KCNN2 Polyclonal Antibody
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KCNN2 Antibody (PA5-41012) in IHC
Immunofluorescence analysis of rat brain section cells using an anti-KCNN2 polyclonal antibody (Product # PA5-41012). Primary Antibody Dilution: 1:500; Secondary Antibody: Anti-rabbit-biotin, streptavidin-diaminobenzidine; Secondary Antibody Dilution: 1:500.
Product Details
PA5-41012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human KCNN2 (aa 443-492).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2605450
Product Specific Information
Peptide sequence: IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 100%; Zebrafish: 93%
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apamin-sensitive small-conductance Ca2+-activated potassium channel; KCa2.2; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel 2; Small conductance calcium-activated potassium channel protein 2
Gene Aliases: hSK2; KCa2.2; KCNN2; SK2; SKCa 2; SKCA2
UniProt ID: (Human) Q9H2S1, (Rat) P70604
Entrez Gene ID: (Human) 3781, (Rat) 54262
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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