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Alomone Labs, LTD
KCNN2 (KCa2.2, SK2) Polyclonal Antibody
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FIGURE: 1 / 1
KCNN2 (KCa2.2, SK2) Antibody (APC-028-GP200UL) in WB
Western blot analysis of rat brain lysate (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4): - 1,2. Guinea pig Anti-KCNN2 (KCa2.2, SK2) Antibody (#APC-028-GP), (1:1000).3,4. Guinea pig Anti-KCNN2 (KCa2.2, SK2) Antibody , preincubated with KCNN2/KCa2.2 Blocking Peptide (#BLP-PC028).
Product Details
APC-028-GP200UL
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)ETQMENYDKHVTYNAERS, corresponding to amino acid residues 542- 559 of rat KCNN2, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel subfamily N member 2
Gene Aliases: fri; KCa2.2; Kcnn2; SK2; SKCA2
UniProt ID: (Rat) P70604, (Mouse) P58390
Entrez Gene ID: (Rat) 54262, (Mouse) 140492
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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