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KCNN3 Antibody (PA5-96511) in WB
Western blot analysis of KCNN3 in extracts of NCI-H460 cells. Samples were incubated with KCNN3 Polyclonal antibody (Product # PA5-96511) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
Product Details
PA5-96511
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3 (NP_7407521)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808313
Product Specific Information
Immunogen sequence: VARKLELTKA EKHVHNFMMD TQLTKRIKNA AANVLRETWL IYKHTKLLKK IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL SDQANTLVDL SKMQNVMYDL ITELNDRSED LEKQIGSLES KLEHLTASFN SLPLLIADTL RQQQQQLLSA IIEARGVSVA VGTTHTPISD SPIGVSSTSF PTPYTSSSSC; Positive Samples: NCI-H460; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; small conductance calcium-activated potassium channel 3; Small conductance calcium-activated potassium channel protein 3
Gene Aliases: hSK3; K3; KCa2.3; KCNN3; SK3; SKCA3
UniProt ID: (Human) Q9UGI6
Entrez Gene ID: (Human) 3782
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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