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Invitrogen
KCNQ5 Polyclonal Antibody
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Product Details
PA5-110817
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human KCNQ5. Recombinant protein control fragment (Product #RP-91239).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2856228
Product Specific Information
Immunogen sequence: LALASFQIPP FECEQTSDYQ SPVDSKDLSG SAQNSGCLSR STSANISRGL QFILTPNEFS AQTFYALSPT MHSQATQVPI SQSDGSAVAA TNTIANQINT APKPAAPTTL QIPPPL
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KQT-like 5; KvLQT5; potassium channel protein; Potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; Potassium voltage-gated channel subfamily KQT member 5; rCG_43583; Voltage-gated potassium channel subunit Kv7.5
Gene Aliases: KCNQ5; Kv7.5
UniProt ID: (Human) Q9NR82
Entrez Gene ID: (Human) 56479
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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