Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
BS-16930R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human KCTD19, amino acids 1-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The KCTD19 (Potassium Channel Tetramerization Domain Containing 19) gene encodes a protein that plays a crucial role in meiotic chromosome organization and male fertility. KCTD19 is located on chromosome 5 in humans. The protein is known to interact with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1), highlighting its role in chromatin organization and transcription regulation during meiosis. Mutations or loss-of-function variants in KCTD19 have been implicated in non-obstructive azoospermia (NOA) and male infertility, as evidenced by studies in both human and mouse models. The gene's function in regulating the individualization of meiotic chromosomes is critical, and disruptions can lead to severe meiotic defects and spermatogenic failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: BTB/POZ domain-containing protein KCTD19; potassium channel tetramerisation domain containing 19; potassium channel tetramerization domain containing 19; Potassium channel tetramerization domain-containing protein 19; testicular tissue protein Li 101
Gene Aliases: 4922504H04Rik; KCTD19; RGD1561326
UniProt ID: (Human) Q17RG1, (Mouse) Q562E2
Entrez Gene ID: (Human) 146212, (Rat) 291965, (Mouse) 279499
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support