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Product Details
65699ACTMOTIF
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
K2K842-13
Immunogen
This KDM2B antibody was raised against a peptide containing human lysine-specific demethylase 2B of isoform a.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [Histone-H3]-lysine-36 demethylase 1B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein containing leucine repeats 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; JmjC domain-containing histone demethylation protein 1B; jumonji C domain-containing histone demethylase 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; lysine (K)-specific demethylase 2B; Lysine-specific demethylase 2B; Protein JEMMA; Protein-containing CXXC domain 2
Gene Aliases: CXXC2; FBL10; FBXL10; JHDM1B; KDM2B; Kiaa3014; NDY1; PCCX2
UniProt ID: (Human) Q8NHM5, (Mouse) Q6P1G2
Entrez Gene ID: (Human) 84678, (Mouse) 30841
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
spermatogenesis
midbrain-hindbrain boundary morphogenesis
fourth ventricle development
lateral ventricle development
third ventricle development
initiation of neural tube closure
positive regulation of cell growth
forebrain development
midbrain development
hindbrain development
histone H2A monoubiquitination
negative regulation of neuron apoptotic process
embryonic camera-type eye morphogenesis
oxidation-reduction process
histone H3-K36 demethylation
positive regulation of stem cell population maintenance
negative regulation of neural precursor cell proliferation
regulation of transcription, DNA-templated
chromatin modification
histone demethylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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