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OriGene
KDM3A/JHDM2A (KDM3A) Monoclonal Antibody (OTI5A7), TrueMAB™
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Product Details
CF812138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5A7
Immunogen
Human recombinant protein fragment corresponding to amino acids 850-1321 of human KDM3A (NP_060903) produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
See Label
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-dimethyl-L-lysine(9) demethylase 3A; DKFZp686A24246; DKFZp686P07111; JmjC domain-containing histone demethylation protein 2A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; Jumonji domain-containing protein 1A; lysine (K)-specific demethylase 3A; Lysine-specific demethylase 3A; probable zinc finger protein; testis specific gene A; Testis-specific gene A protein; testis-specific protein A; Zinc finger protein TSGA
Gene Aliases: 1700105C21Rik; C230043E16Rik; JHDM2A; JHMD2A; JMJD1; JMJD1A; KDM2A; KDM3A; KIAA0742; TGSA; TSGA
UniProt ID: (Human) Q9Y4C1, (Mouse) Q6PCM1, (Rat) Q63679
Entrez Gene ID: (Human) 55818, (Mouse) 104263, (Rat) 312440
transcription regulatory region sequence-specific DNA binding
core promoter binding
transcription factor activity, sequence-specific DNA binding
iron ion binding
histone demethylase activity
androgen receptor binding
dioxygenase activity
sulfonate dioxygenase activity
protein binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
molecular_function
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
spermatid nucleus elongation
hormone-mediated signaling pathway
positive regulation of gene expression
chromatin modification
cell differentiation
androgen receptor signaling pathway
histone H3-K9 demethylation
histone H3-K9 dimethylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
formaldehyde biosynthetic process
negative regulation of histone H3-K9 methylation
oxidation-reduction process
response to hypoxia
male gonad development
regulation of stem cell population maintenance
regulation of stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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