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Immunogen sequence: GQGQGRGCSR GRGHGCCTRE LGTEEPTVQP ASKRRLLMGT RSRAQGHRPQ LPLANDLMTN LS
Highest antigen sequence identity to the following orthologs: Mouse - 31%, Rat - 35%.
The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [histone H3]-trimethyl-L-lysine(9) demethylase 4E; KDM4D-like protein; lysine (K)-specific demethylase 4E; Lysine-specific demethylase 4D-like; Lysine-specific demethylase 4E
Gene Aliases: JMJD2E; KDM4DL; KDM4E
UniProt ID: (Human) B2RXH2
Entrez Gene ID: (Human) 390245
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