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Proteintech
KDM5C Polyclonal Antibody
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Product Details
14426-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KDM5C Fusion Protein Ag5791 (1-351 aa encoded by BC054499)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEPGSDDFL PPPECPVFEP SWAEFRDPLG YIAKIRPIAE KSGICKIRPP ADWQPPFAVE VDNFRFTPRI QRLNELEAQT RVKLNYLDQI AKFWEIQGSS LKIPNVERRI LDLYSLSKIV VEEGGYEAIC KDRRWARVAQ RLNYPPGKNI GSLLRSHYER IVYPYEMYQS GANLVCNTRP FDNEEKDKEY KPHSIPLRQS VQPSKFNSYG RRAKRLQPDP EPTEEDIEKN PELKKLQIYG AGPKMMGLGL MAKDKTLRKK DKEGPECPPT VVVKEELGGD VKVESTSPKT FLESKEELSH SPEPCTKMTM RLRRNHSNAQ FIESYVCRMC SRGDEDDKLL LCDGCDDNYH IF (1-351 aa encoded by BC054499)
Target Information
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; Histone demethylase JARID1C; JmjC domain-containing protein SMCX; jumonji, AT rich interactive domain 1C (Rbp2 like); Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; Lysine-specific demethylase 5C; Protein SmcX; Protein Xe169; sele; selected mouse cDNA on the X; Smcx homolog, X chromosome; Smcy homolog, X-linked
Gene Aliases: D930009K15Rik; DXS1272E; JARID1C; KDM5C; Kiaa0234; mKIAA0234; MRX13; MRXJ; MRXSCJ; MRXSJ; RGD1560601; SMCX; XE169
UniProt ID: (Human) P41229, (Mouse) P41230
Entrez Gene ID: (Human) 8242, (Mouse) 20591, (Rat) 317432
DNA binding
zinc ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
histone demethylase activity
histone demethylase activity (H3-K4 specific)
sulfonate dioxygenase activity
RNA polymerase II transcription factor binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
identical protein binding
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
molecular_function
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone H3-K4 demethylation
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
rhythmic process
oxidation-reduction process
response to toxic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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