Proteintech

KEAP1 Polyclonal Antibody

KEAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KEAP1 Antibody (10503-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 10503-2-AP ( KEAP1 Antibody) at dilution of 1:200 (under 10x lens).

KEAP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10503-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 454 publications 454 publications

Immunohistochemistry (IHC)

View 32 publications 32 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 48 publications 48 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 33 publications 33 publications

Miscellaneous PubMed (MISC)

View 3 publications 3 publications

Not applicable (N/A)

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KEAP1 Fusion Protein Ag0779 (325-624 aa encoded by BC002930)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1.

Immunogen sequence: GRLIYTAGG YFRQSLSYLE AYNPSDGTWL RLADLQVPRS GLAGCVVGGL LYAVGGRNNS PDGNTDSSAL DCYNPMTNQW SPCAPMSVPR NRIGVGVIDG HIYAVGGSHG CIHHNSVERY EPERDEWHLV APMLTRRIGV GVAVLNRLLY AVGGFDGTNR LNSAECYYPE RNEWRMITAM NTIRSGAGVC VLHNCIYAAG GYDGQDQLNS VERYDVETET WTFVAPMKHR RSALGITVHQ GRIYVLGGYD GHTFLDSVEC YDPDTDTWSE VTRMTSGRSG VGVAVTMEPC RKQIDQQNCT C (325-624 aa encoded by BC002930)

Target Information

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Nrf2 and NF-қB interplay in tamoxifen-induced hepatic toxicity: A promising therapeutic approach of sildenafil and low-dose γ radiation.

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Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.

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Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.

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Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier.

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Tue Jun 27 00:00:00 UTC 2023

Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.

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Xiang X,Chen J,Jiang T,Yan C,Kang Y,Zhang M,Xiang K,Guo J,Jiang G,Wang C,Yang X,Chen Z

Fri Sep 01 00:00:00 UTC 2023

Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.

Drug delivery and translational research

Xiang X,Chen J,Jiang T,Yan C,Kang Y,Zhang M,Xiang K,Guo J,Jiang G,Wang C,Yang X,Chen Z

Fri Sep 01 00:00:00 UTC 2023

Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.

Drug delivery and translational research

Xiang X,Chen J,Jiang T,Yan C,Kang Y,Zhang M,Xiang K,Guo J,Jiang G,Wang C,Yang X,Chen Z

Fri Sep 01 00:00:00 UTC 2023

Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.

Drug delivery and translational research

Xiang X,Chen J,Jiang T,Yan C,Kang Y,Zhang M,Xiang K,Guo J,Jiang G,Wang C,Yang X,Chen Z

Fri Sep 01 00:00:00 UTC 2023

Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes.

Aging

Tsui KH,Li CJ

Mon Jan 09 00:00:00 UTC 2023

Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.

Bioorganic chemistry

Qi Z,Tong Y,Luo H,Chen M,Zhou N,Chen L

Wed Mar 01 00:00:00 UTC 2023

Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.

Bioorganic chemistry

Qi Z,Tong Y,Luo H,Chen M,Zhou N,Chen L

Wed Mar 01 00:00:00 UTC 2023

Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.

Bioorganic chemistry

Qi Z,Tong Y,Luo H,Chen M,Zhou N,Chen L

Wed Mar 01 00:00:00 UTC 2023

Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.

Bioorganic chemistry

Qi Z,Tong Y,Luo H,Chen M,Zhou N,Chen L

Wed Mar 01 00:00:00 UTC 2023

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.

Pharmaceutical biology

Ding J,Lu B,Liu L,Zhong Z,Wang N,Li B,Sheng W,He Q

Fri Dec 01 00:00:00 UTC 2023

A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.

Disease models & mechanisms

Ngo V,Brickenden A,Liu H,Yeung C,Choy WY,Duennwald ML

Fri Apr 01 00:00:00 UTC 2022

Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H₂O₂-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.

Frontiers in pharmacology

Yang T,Lin X,Li H,Zhou X,Fan F,Yang J,Luo Y,Liu X

Fri Jul 29 00:00:00 UTC 2022

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.

Stem cell research & therapy

Yin BF,Li ZL,Yan ZQ,Guo Z,Liang JW,Wang Q,Zhao ZD,Li PL,Hao RC,Han MY,Li XT,Mao N,Ding L,Chen DF,Gao Y,Zhu H

Tue Jun 07 00:00:00 UTC 2022

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell chemical biology

Kunder R,Velyunskiy M,Dunne SF,Cho BK,Kanojia D,Begg L,Orriols AM,Fleming-Trujillo E,Vadlamani P,Vialichka A,Bolin R,Perrino JN,Roth D,Clutter MR,Zielinski-Mozny NA,Goo YA,Cristofanilli M,Mendillo ML,Vassilopoulos A,Horiuchi D

Thu Mar 17 00:00:00 UTC 2022

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.

Bioorganic & medicinal chemistry

Wang W,Xiong L,Li Y,Song Z,Sun D,Li H,Chen L

Tue Feb 15 00:00:00 UTC 2022

Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.

Drug design, development and therapy

Xiao S,Zhou Y,Wang Q,Yang D

Thu Jan 05 00:00:00 UTC 2023

Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.

Antioxidants (Basel, Switzerland)

Wang K,Tang Y,Wu X,Liang H,Chen D,Yu B,He J,Mao X,Huang Z,Yan H,Wu A,Luo Y,Zheng P,Yu J,Wang H,Luo J

Sun Sep 18 00:00:00 UTC 2022

A dual Keap1 and p47^phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.

Cell death & disease

Wang ZC,Niu KM,Wu YJ,Du KR,Qi LW,Zhou YB,Sun HJ

Mon Sep 26 00:00:00 UTC 2022

Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction.

International journal of molecular sciences

Mundal SB,Rakner JJ,Silva GB,Gierman LM,Austdal M,Basnet P,Elschot M,Bakke SS,Ostrop J,Thomsen LCV,Moses EK,Acharya G,Bjørge L,Iversen AC

Thu Feb 10 00:00:00 UTC 2022

Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.

Frontiers in pharmacology

Jia Z,Wang P,Xu Y,Feng G,Wang Q,He X,Song Y,Liu P,Chen J

Sat Oct 15 00:00:00 UTC 2022

Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells.

Frontiers in nutrition

Wang M,Huang H,Wang L,Yin L,Yang H,Chen C,Zheng Q,He S

Tue Nov 22 00:00:00 UTC 2022

Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wang YF,Chang YY,Zhang XM,Gao MT,Zhang QL,Li X,Zhang L,Yao WF

Sun May 01 00:00:00 UTC 2022

Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang J,Zhang M,Zhang WH,Zhu QM,Ning J,Huo XK,Xiao HT,Sun CP

Thu Dec 01 00:00:00 UTC 2022

HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.

Oxidative medicine and cellular longevity

Han S,Lin F,Qi Y,Liu C,Zhou L,Xia Y,Chen K,Xing J,Liu Z,Yu W,Zhang Y,Zhou X,Rao T,Cheng F

Mon Jun 06 00:00:00 UTC 2022

USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity.

The Journal of biological chemistry

Sango J,Kakihana T,Takahashi M,Katsuragi Y,Anisimov S,Komatsu M,Fujii M

Sat Jan 01 00:00:00 UTC 2022

USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity.

The Journal of biological chemistry

Sango J,Kakihana T,Takahashi M,Katsuragi Y,Anisimov S,Komatsu M,Fujii M

Sat Jan 01 00:00:00 UTC 2022

Carbon Monoxide-Releasing Molecule-3 Suppresses the Malignant Biological Behavior of Tongue Squamous Cell Carcinoma via Regulating Keap1/Nrf2/HO-1 Signaling Pathway.

BioMed research international

Dai Y,Chen H,Pan Y,Song H

Wed Sep 28 00:00:00 UTC 2022

Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.

Free radical biology & medicine

Xi J,Zhang Z,Wang Z,Wu Q,He Y,Xu Y,Ding Z,Zhao H,Da H,Zhang F,Zhao H,Fang J

Thu Sep 01 00:00:00 UTC 2022

Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.

International immunopharmacology

Zhu X,Duan F,Zhang Y,Wang X,Wang Y,Chen J,Zhang L,Wu M,Pan Z,Chen B

Sat Oct 01 00:00:00 UTC 2022

(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H₂O₂ Through Activation of Nrf2 Pathway.

Frontiers in pharmacology

Qi S,Zhang X,Fu Z,Pi A,Shi F,Fan Y,Zhang J,Xiao T,Shang D,Lin M,Gao N,Chang J,Gao Y

Tue Aug 09 00:00:00 UTC 2022

Berberine prevents lethal EV71 neurological infection in newborn mice.

Frontiers in pharmacology

Cui G,Wang H,Yang C,Zhou X,Wang J,Wang T,Ma T

Fri Nov 18 00:00:00 UTC 2022

MiR-125b attenuates retinal pigment epithelium oxidative damage via targeting Nrf2/HIF-1α signal pathway.

Experimental cell research

Liu JX,Ma DY,Zhi XY,Wang MW,Zhao JY,Qin Y

Sat Jan 01 00:00:00 UTC 2022

Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.

Journal of nanobiotechnology

Li N,Du H,Mao L,Xu G,Zhang M,Fan Y,Dong X,Zheng L,Wang B,Qin X,Jiang X,Chen C,Zou Z,Zhang J

Sat Jun 11 00:00:00 UTC 2022

Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.

Antioxidants (Basel, Switzerland)

Li DM,Wu YX,Hu ZQ,Wang TC,Zhang LL,Zhou Y,Tong X,Xu JY,Qin LQ

Sun Jul 31 00:00:00 UTC 2022

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.

Experimental cell research

Yang X,Zhang F,Liu X,Meng J,Du S,Shao J,Liu J,Fang M

Tue Nov 01 00:00:00 UTC 2022

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.

Experimental cell research

Yang X,Zhang F,Liu X,Meng J,Du S,Shao J,Liu J,Fang M

Tue Nov 01 00:00:00 UTC 2022

Lipoxin A₄ and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.

Experimental cell research

Xu F,Zhang J,Zhou X,Hao H

Tue Mar 01 00:00:00 UTC 2022

Lipoxin A₄ and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.

Experimental cell research

Xu F,Zhang J,Zhou X,Hao H

Tue Mar 01 00:00:00 UTC 2022

Lipoxin A₄ and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.

Experimental cell research

Xu F,Zhang J,Zhou X,Hao H

Tue Mar 01 00:00:00 UTC 2022

Lipoxin A₄ and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.

Experimental cell research

Xu F,Zhang J,Zhou X,Hao H

Tue Mar 01 00:00:00 UTC 2022

Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury.

Journal of proteome research

Luo C,Ding W,Yang C,Zhang W,Liu X,Deng H

Fri Jul 01 00:00:00 UTC 2022

An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.

Acta biomaterialia

Zhao X,Sun J,Dong J,Guo C,Cai W,Han J,Shen H,Lv S,Zhang R

Fri Jul 15 00:00:00 UTC 2022

Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue.

Molecules (Basel, Switzerland)

Li Y,Hao D,Wei D,Xiao Y,Liu L,Li X,Wang L,Gan Y,Yan W,Ke B,Jiang X

Mon Oct 10 00:00:00 UTC 2022

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.

Nature communications

Zhou W,Wu WH,Si ZL,Liu HL,Wang H,Jiang H,Liu YF,Alolga RN,Chen C,Liu SJ,Bian XY,Shan JJ,Li J,Tan NH,Zhang ZH

Fri Oct 14 00:00:00 UTC 2022

Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up-regulation and increased apoptosis resistance upon vemurafenib treatment.

Cancer medicine

Weitzenböck HP,Gschwendtner A,Wiesner C,Depke M,Schmidt F,Trautinger F,Hengstschläger M,Hundsberger H,Mikula M

Tue Feb 01 00:00:00 UTC 2022

Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.

Frontiers in pharmacology

Wang J,Wang K,Ding L,Zhao P,Zhang C,Wang H,Yang Z,Liu Z

Tue Sep 03 00:00:00 UTC 2024

GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling.

Cancer letters

Chen T,Jinlin D,Wang F,Yuan Z,Xue J,Lu T,Huang W,Liu Y,Zhang Y

Sun Jul 10 00:00:00 UTC 2022

6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.

The Journal of nutritional biochemistry

Han X,Liu P,Zheng B,Zhang M,Zhang Y,Xue Y,Liu C,Chu X,Wang X,Sun S,Chu L

Wed Jun 01 00:00:00 UTC 2022

Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.

The Journal of nutritional biochemistry

Zhong CC,Zhao T,Hogstrand C,Chen F,Song CC,Luo Z

Tue Feb 01 00:00:00 UTC 2022

Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q

Thu Sep 01 00:00:00 UTC 2022

The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.

Journal of ethnopharmacology

Xu LT,Wang T,Fang KL,Zhao Y,Wang XN,Ren DM,Shen T

Sun Jan 30 00:00:00 UTC 2022

Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling.

Brain research bulletin

Hua D,Luo A,Wu Z,Huang C,Li S,Xu X,Xu J,Yang C,Wang D,Liu C

Fri Apr 01 00:00:00 UTC 2022

The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.

Phytotherapy research : PTR

Wu XY,Wang T,Hu HX,Zhang K,Zhao Y,Zhao BB,Lou HX,Wang XN,Shen T

Fri Apr 01 00:00:00 UTC 2022

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease.

Redox biology

Chao CC,Huang CL,Cheng JJ,Chiou CT,Lee IJ,Yang YC,Hsu TH,Yei CE,Lin PY,Chen JJ,Huang NK

Thu Dec 01 00:00:00 UTC 2022

Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile.

Environmental pollution (Barking, Essex : 1987)

Qi M,Wang N,Xiao Y,Deng Y,Zha A,Tan B,Wang J,Yin Y,Liao P

Sat Jan 15 00:00:00 UTC 2022

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1.

Antioxidants (Basel, Switzerland)

Ngo V,Karunatilleke NC,Brickenden A,Choy WY,Duennwald ML

Thu Jan 27 00:00:00 UTC 2022

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1.

Antioxidants (Basel, Switzerland)

Ngo V,Karunatilleke NC,Brickenden A,Choy WY,Duennwald ML

Thu Jan 27 00:00:00 UTC 2022

Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.

Oxidative medicine and cellular longevity

Guan D,Zhou W,Wei H,Wang T,Zheng K,Yang C,Feng R,Xu R,Fu Y,Li C,Li Y,Li C

Thu Mar 24 00:00:00 UTC 2022

Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM_2.5.

Ecotoxicology and environmental safety

Shi F,Zhang Z,Cui H,Wang J,Wang Y,Tang Y,Yang W,Zou P,Ling X,Han F,Liu J,Chen Q,Liu C,Cao J,Ao L

Wed Jun 15 00:00:00 UTC 2022

Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Li S,Ma Y,Ye S,Su Y,Hu D,Xiao F

Wed Jun 01 00:00:00 UTC 2022

Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.

Meat science

Zhang X,Liu X,Wan F,You W,Tan X,Sheng Q,Li C,Hu Z,Liu G,Zhao H

Tue Mar 01 00:00:00 UTC 2022

Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.

Aging cell

Zhu L,He S,Huang L,Ren D,Nie T,Tao K,Xia L,Lu F,Mao Z,Yang Q

Wed Jun 01 00:00:00 UTC 2022

The Protective Effect of Ursolic Acid on Unilateral Ureteral Obstruction in Rats by Activating the Nrf2/HO-1 Antioxidant Signaling Pathway.

Computational intelligence and neuroscience

Pei J,Wu M,Cai S,Peng J,Zhan X,Wang D,Wang W,An N

Wed Sep 07 00:00:00 UTC 2022

The Protective Effect of Ursolic Acid on Unilateral Ureteral Obstruction in Rats by Activating the Nrf2/HO-1 Antioxidant Signaling Pathway.

Computational intelligence and neuroscience

Pei J,Wu M,Cai S,Peng J,Zhan X,Wang D,Wang W,An N

Wed Sep 07 00:00:00 UTC 2022

Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.

Toxicology letters

Li F,Zhou J,Zhu X,Lu R,Ye Y,Wang S,Xing G,Shen H

Fri Jul 15 00:00:00 UTC 2022

Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.

Journal of applied toxicology : JAT

Liu YP,Yuan XY,Li XY,Wang Y,Sun ZB,Deng WH,Lei YD,Huang L,Jiang TY,Zhang ZH

Tue Feb 01 00:00:00 UTC 2022

Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.

Biochemical pharmacology

Sun X,Dong M,Gao Y,Wang Y,Du L,Liu Y,Wang Q,Ji K,He N,Wang J,Zhang M,Gu Y,Song H,Zhai H,Feng L,Xu C,Liu Q

Sun May 01 00:00:00 UTC 2022

The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.

Inflammation

Chen S,Huang Y,Su H,Zhu W,Wei Y,Long Y,Shi Y,Wei J

Mon Aug 01 00:00:00 UTC 2022

Collagen peptides from Acaudina molpadioides prevent CCl₄ -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.

Journal of food science

Li J,Li Y,Lin S,Zhao W,Chen Y,Jin H

Sun May 01 00:00:00 UTC 2022

Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.

Animal science journal = Nihon chikusan Gakkaiho

Zhang J,Yan E,Zhang L,Wang T,Wang C

Fri Jun 17 00:00:00 UTC 2022

Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.

Food & function

Jia Y,Guo H,Cheng X,Zhang Y,Si M,Shi J,Ma D

Mon Apr 04 00:00:00 UTC 2022

Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.

Food & function

Zhang QY,Han SC,Huang RP,Jiang MY,Yan CY,Li XY,Zhan YJ,Li XM,Li YF,Kurihara H,Tan RR,Li WX,He RR

Mon Jul 04 00:00:00 UTC 2022

Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion.

Respiratory research

Shao FJ,Guo XL,Xu JX,Liu R,Li DY,Li QH,Zhou T,Fang C,Tan X

Sun Oct 23 00:00:00 UTC 2022

Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.

Journal of agricultural and food chemistry

Ding XQ,Jian TY,Gai YN,Niu GT,Liu Y,Meng XH,Li J,Lyu H,Ren BR,Chen J

Wed Mar 09 00:00:00 UTC 2022

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Cell

Mo X,Niu Q,Ivanov AA,Tsang YH,Tang C,Shu C,Li Q,Qian K,Wahafu A,Doyle SP,Cicka D,Yang X,Fan D,Reyna MA,Cooper LAD,Moreno CS,Zhou W,Owonikoko TK,Lonial S,Khuri FR,Du Y,Ramalingam SS,Mills GB,Fu H

Thu May 26 00:00:00 UTC 2022

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Cell

Mo X,Niu Q,Ivanov AA,Tsang YH,Tang C,Shu C,Li Q,Qian K,Wahafu A,Doyle SP,Cicka D,Yang X,Fan D,Reyna MA,Cooper LAD,Moreno CS,Zhou W,Owonikoko TK,Lonial S,Khuri FR,Du Y,Ramalingam SS,Mills GB,Fu H

Thu May 26 00:00:00 UTC 2022

Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

Bioengineered

Zhu W,Tang H,Li J,Guedes RM,Cao L,Guo C

Fri Apr 01 00:00:00 UTC 2022

Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.

Amino acids

Li A,Li XM,Song CG,Xiao X,Yao WM,Tian HS

Fri Jul 01 00:00:00 UTC 2022

m⁶A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.

Autophagy

Liang D,Lin WJ,Ren M,Qiu J,Yang C,Wang X,Li N,Zeng T,Sun K,You L,Yan L,Wang W

Wed Jun 01 00:00:00 UTC 2022

Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma.

Cancers

Fahrmann JF,Tanaka I,Irajizad E,Mao X,Dennison JB,Murage E,Casabar J,Mayo J,Peng Q,Celiktas M,Vykoukal JV,Park S,Taguchi A,Delgado O,Tripathi SC,Katayama H,Soto LMS,Rodriguez-Canales J,Behrens C,Wistuba I,Hanash S,Ostrin EJ

Sat May 21 00:00:00 UTC 2022

Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma.

Free radical biology & medicine

Li L,Feng R,Li Y,Yu X,Liu Y,Zhao Y,Liu Z

Tue Nov 01 00:00:00 UTC 2022

Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma.

Free radical biology & medicine

Li L,Feng R,Li Y,Yu X,Liu Y,Zhao Y,Liu Z

Tue Nov 01 00:00:00 UTC 2022

Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.

Frontiers in physiology

Guo J,Hu H,Chen Z,Xu J,Nie J,Lu J,Ma L,Ji H,Yuan J,Xu B

Sat Jul 16 00:00:00 UTC 2022

A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects.

Molecules and cells

Lee JA,Kwon YW,Kim HR,Shin N,Son HJ,Cheong CS,Kim DJ,Hwang O

Thu Mar 31 00:00:00 UTC 2022

Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.

Ecotoxicology and environmental safety

Liu F,Wang Y,Chen L,Bello BK,Zhang T,Yang H,Li X,Pan E,Feng H,Dong J

Sat Oct 01 00:00:00 UTC 2022

Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.

Oxidative medicine and cellular longevity

Yan CY,Sun J,Yu GY,Liu JH,Huang RP,Han SC,Zhang QY,Li XM,Yan JG,Kurihara H,Li WX,Li YF,He RR

Fri Sep 09 00:00:00 UTC 2022

Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.

Gut microbes

Sargin P,Roethle MF,Jia S,Pant T,Ciecko AE,Atkinson SN,Salzman NH,Teng RJ,Chen YG,Cabrera SM,Hessner MJ

Fri Oct 21 00:00:00 UTC 2022

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway.

Head & face medicine

Xu J,Wu H,Sun J,Gong Z,Lu X,Yang E,Chen Z,Huang S,Nong X,Zhang D

Fri May 06 00:00:00 UTC 2022

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway.

Head & face medicine

Xu J,Wu H,Sun J,Gong Z,Lu X,Yang E,Chen Z,Huang S,Nong X,Zhang D

Fri May 06 00:00:00 UTC 2022

The dual role of p62 in ferroptosis of glioblastoma according to p53 status.

Cell & bioscience

Yuan F,Sun Q,Zhang S,Ye L,Xu Y,Deng G,Xu Z,Zhang S,Liu B,Chen Q

Fri Feb 25 00:00:00 UTC 2022

Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.

Chemical biology & drug design

Zhu W,Tang H,Cao L,Zhang J,Li J,Ma D,Guo C

Fri Jul 01 00:00:00 UTC 2022

Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.

Oncology reports

Wang T,Liu J,Huang X,Zhang C,Shangguan M,Chen J,Wu S,Chen M,Yang Z,Zhao S

Tue Nov 01 00:00:00 UTC 2022

Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H₂O₂-Induced Oxidative Stress in Human Chondrocytes.

Antioxidants (Basel, Switzerland)

Zhu L,Ma M,Ahn DU,Guyonnet V,Wang L,Zheng Y,He Q,Xiong H,Huang X

Fri Dec 09 00:00:00 UTC 2022

Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen J,Zhang J,Chen T,Bao S,Li J,Wei H,Hu X,Liang Y,Liu F,Yan S

Tue Nov 01 00:00:00 UTC 2022

Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen J,Zhang J,Chen T,Bao S,Li J,Wei H,Hu X,Liang Y,Liu F,Yan S

Tue Nov 01 00:00:00 UTC 2022

Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.

Cell death & disease

Liu H,Zhao D,Li H,Zhang W,Lin Q,Wang X,Zheng S,Zhang L,Li L,Hu S,Hu Y

Mon Feb 21 00:00:00 UTC 2022

Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption.

Neuroscience letters

Duan W,Ye P,Leng YQ,Liu DH,Sun JC,Tan X,Wang WZ

Sun Nov 20 00:00:00 UTC 2022

Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.

European journal of pharmacology

Zhang L,Zhu XZ,Badamjav R,Zhang JZ,Kou JP,Yu BY,Li F

Tue Feb 15 00:00:00 UTC 2022

Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.

Microbiome

Wang L,Liu Q,Chen Y,Zheng X,Wang C,Qi Y,Dong Y,Xiao Y,Chen C,Chen T,Huang Q,Zhai Z,Long C,Yang H,Li J,Wang L,Zhang G,Liao P,Liu YX,Huang P,Huang J,Wang Q,Chu H,Yin J,Yin Y

Wed Jun 01 00:00:00 UTC 2022

Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets.

Antioxidants (Basel, Switzerland)

Xiao Y,Huang R,Wang N,Deng Y,Tan B,Yin Y,Qi M,Wang J

Thu Jan 27 00:00:00 UTC 2022

Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.

Journal of cardiovascular translational research

Li H,Cao T,Ding W,Liang L,Fan GC,Qu L,Peng T

Mon Aug 01 00:00:00 UTC 2022

Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.

Antioxidants & redox signaling

Xun Y,Zhou P,Yang Y,Li C,Zhang J,Hu H,Qin B,Zhang Z,Wang Q,Lu Y,Wang S

Sat Jan 01 00:00:00 UTC 2022

Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.

Free radical biology & medicine

Zhang Y,Yang S,Qiu Z,Huang L,Huang L,Liang Y,Liu X,Wang M,Zhou B

Sat Oct 01 00:00:00 UTC 2022

Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.

Free radical biology & medicine

Zhang Y,Yang S,Qiu Z,Huang L,Huang L,Liang Y,Liu X,Wang M,Zhou B

Sat Oct 01 00:00:00 UTC 2022

Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.

Free radical biology & medicine

Yang C,Wang T,Zhao Y,Meng X,Ding W,Wang Q,Liu C,Deng H

Mon Aug 01 00:00:00 UTC 2022

Immature rat testis sustained long-term development using an integrative model.

Biological research

Ma Y,Chen J,Li H,Xu F,Chong T,Wang Z,Zhang L

Tue Oct 04 00:00:00 UTC 2022

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.

Environmental science and pollution research international

Ma Y,Li S,Tang S,Ye S,Liang N,Liang Y,Xiao F

Fri Jul 01 00:00:00 UTC 2022

A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.

Redox biology

Deng Q,Yang S,Sun L,Huang K,Dong K,Zhu Y,Cao Y,Li Y,Wu S,Huang R

Tue Feb 01 00:00:00 UTC 2022

Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.

Oxidative medicine and cellular longevity

Chen P,Yang J,Wu N,Han B,Kastelic JP,Gao J

Fri Mar 18 00:00:00 UTC 2022

Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy.

Journal of agricultural and food chemistry

Zhang X,Chen Y,Li H,Chen B,Liu Z,Wu G,Li C,Li R,Cao Y,Zhou J,Shen M,Liu H,Tao J

Wed Jul 06 00:00:00 UTC 2022

Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.

Frontiers in molecular biosciences

Zou P,Zhang X,Zhang R,Chai X,Zhao Y,Li E,Zhang Q,Yan R,Yang J,Liao B

Sat Apr 09 00:00:00 UTC 2022

Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.

Toxicology

Zhou X,Wang S,Zhou R,Zhang T,Wang Y,Zhang Q,Cong R,Ji C,Luan J,Yao L,Zhou X,Song N

Wed Jun 15 00:00:00 UTC 2022

PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.

Redox biology

Lee DH,Park JS,Lee YS,Bae SH

Fri Apr 01 00:00:00 UTC 2022

Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction.

Breast cancer research : BCR

Mir S,Ormsbee Golden BD,Griess BJ,Vengoji R,Tom E,Kosmacek EA,Oberley-Deegan RE,Talmon GA,Band V,Teoh-Fitzgerald ML

Thu Jul 14 00:00:00 UTC 2022

Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.

Oxidative medicine and cellular longevity

Li X,Chen J,Yuan S,Zhuang X,Qiao T

Mon Dec 12 00:00:00 UTC 2022

Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.

Environmental science & technology

Chen GH,Song CC,Zhao T,Hogstrand C,Wei XL,Lv WH,Song YF,Luo Z

Tue Feb 15 00:00:00 UTC 2022

Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.

International journal of molecular sciences

Shi K,Xiao Y,Dong Y,Wang D,Xie Y,Tu J,Xu K,Zhou Z,Cao G,Liu Y

Sat Dec 17 00:00:00 UTC 2022

Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

Free radical biology & medicine

Yang R,Zhang J,Li J,Qin R,Chen J,Wang R,Goltzman D,Miao D

Sat Jan 01 00:00:00 UTC 2022

Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.

ChemMedChem

Ye H,Ma Z,Liu L,Zhang T,Han Q,Xiang Z,Xia Y,Ke Y,Guan X,Shi Q,Ataullakhanov FI,Panteleev M

Fri Dec 16 00:00:00 UTC 2022

Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.

Journal of controlled release : official journal of the Controlled Release Society

Zhao R,Wang L,Wang T,Xian P,Wang H,Long Q

Sun May 01 00:00:00 UTC 2022

Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model.

Laboratory animal research

Joelsson JP,Asbjarnarson A,Sigurdsson S,Kricker J,Valdimarsdottir B,Thorarinsdottir H,Starradottir E,Gudjonsson T,Ingthorsson S,Karason S

Fri Jul 22 00:00:00 UTC 2022

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.

Antioxidants (Basel, Switzerland)

Fu F,Lai Q,Hu J,Zhang L,Zhu X,Kou J,Yu B,Li F

Fri Mar 18 00:00:00 UTC 2022

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.

Antioxidants (Basel, Switzerland)

Fu F,Lai Q,Hu J,Zhang L,Zhu X,Kou J,Yu B,Li F

Fri Mar 18 00:00:00 UTC 2022

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.

Antioxidants (Basel, Switzerland)

Fu F,Lai Q,Hu J,Zhang L,Zhu X,Kou J,Yu B,Li F

Fri Mar 18 00:00:00 UTC 2022

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.

Antioxidants (Basel, Switzerland)

Fu F,Lai Q,Hu J,Zhang L,Zhu X,Kou J,Yu B,Li F

Fri Mar 18 00:00:00 UTC 2022

Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.

Food & function

Li P,Liu Y,Zhao J,Pan W,He Y,Fu S,Liu Y,Xu YJ

Mon Nov 14 00:00:00 UTC 2022

Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang J,Zhang M,Zhang WH,Zhu QM,Huo XK,Sun CP,Ma XC,Xiao HT

Thu Dec 01 00:00:00 UTC 2022

Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.

In vitro cellular & developmental biology. Animal

Chen TY,Zheng SK

Sat Oct 01 00:00:00 UTC 2022

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Current biology : CB

Nieto-Torres JL,Shanahan SL,Chassefeyre R,Chaiamarit T,Zaretski S,Landeras-Bueno S,Verhelle A,Encalada SE,Hansen M

Mon Aug 09 00:00:00 UTC 2021

Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.

Saudi journal of biological sciences

Jiang W,Wan L,Chen P,Lu W

Wed Sep 01 00:00:00 UTC 2021

Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.

Journal of animal science and biotechnology

Chen Y,Zhang H,Chen Y,Jia P,Ji S,Zhang Y,Wang T

Thu Jun 10 00:00:00 UTC 2021

H₂S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.

Apoptosis : an international journal on programmed cell death

Li N,Wang J,Zang X,Wang Z,Zhang T,Zhao B,Miao J,Lin Z

Mon Feb 01 00:00:00 UTC 2021

Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.

Journal of cellular and molecular medicine

Liu K,Yang W,Hu M,Xie W,Huang J,Cui M,He X,Nie X

Thu Apr 01 00:00:00 UTC 2021

H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.

Technology and health care : official journal of the European Society for Engineering and Medicine

Li Y,Chandra TP,Song X,Nie L,Liu M,Yi J,Zheng X,Chu C,Yang J

Wed Aug 18 00:00:00 UTC 2021

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.

Redox biology

Sriramajayam K,Peng D,Lu H,Zhou S,Bhat N,McDonald OG,Que J,Zaika A,El-Rifai W

Thu Jul 01 00:00:00 UTC 2021

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.

Redox biology

Sriramajayam K,Peng D,Lu H,Zhou S,Bhat N,McDonald OG,Que J,Zaika A,El-Rifai W

Thu Jul 01 00:00:00 UTC 2021

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.

Frontiers in pharmacology

Jia Y,Li J,Liu P,Si M,Jin Y,Wang H,Ma D,Chu L

Tue Nov 02 00:00:00 UTC 2021

Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.

Theranostics

Luo Q,Xian P,Wang T,Wu S,Sun T,Wang W,Wang B,Yang H,Yang Y,Wang H,Liu W,Long Q

Fri Jul 30 00:00:00 UTC 2021

Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.

Drug design, development and therapy

Pang Z,Jiang Z,Zhu R,Song C,Tang H,Cao L,Guo C

Thu Jan 20 00:00:00 UTC 2022

Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.

Journal of agricultural and food chemistry

Hu S,Li S,Liu Y,Sun K,Luo L,Zeng L

Wed Sep 15 00:00:00 UTC 2021

Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.

Journal of ethnopharmacology

Lu Q,Gu W,Luo C,Wang L,Hua W,Sun Y,Tang L

Wed Feb 10 00:00:00 UTC 2021

Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.

Antioxidants (Basel, Switzerland)

Lin CY,Chang CB,Wu RC,Chao A,Lee YS,Tsai CN,Chen CH,Yen CF,Tsai CL

Fri Nov 26 00:00:00 UTC 2021

Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.

Antioxidants (Basel, Switzerland)

Lin CY,Chang CB,Wu RC,Chao A,Lee YS,Tsai CN,Chen CH,Yen CF,Tsai CL

Fri Nov 26 00:00:00 UTC 2021

Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.

Antioxidants (Basel, Switzerland)

Lin CY,Chang CB,Wu RC,Chao A,Lee YS,Tsai CN,Chen CH,Yen CF,Tsai CL

Fri Nov 26 00:00:00 UTC 2021

Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.

Antioxidants (Basel, Switzerland)

Lin CY,Chang CB,Wu RC,Chao A,Lee YS,Tsai CN,Chen CH,Yen CF,Tsai CL

Fri Nov 26 00:00:00 UTC 2021

Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.

Ecotoxicology and environmental safety

Cao L,Zhao J,Ma L,Chen J,Xu J,Rahman SU,Feng S,Li Y,Wu J,Wang X

Wed Dec 01 00:00:00 UTC 2021

Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.

The Journal of biological chemistry

Faruk MO,Ichimura Y,Kageyama S,Komatsu-Hirota S,El-Gowily AH,Sou YS,Koike M,Noda NN,Komatsu M

Wed Dec 01 00:00:00 UTC 2021

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.

Free radical biology & medicine

Zhang MH,Li J,Zhu XY,Zhang YQ,Ye ST,Leng YR,Yang T,Zhang H,Kong LY

Sat Feb 20 00:00:00 UTC 2021

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.

Free radical biology & medicine

Zhang MH,Li J,Zhu XY,Zhang YQ,Ye ST,Leng YR,Yang T,Zhang H,Kong LY

Sat Feb 20 00:00:00 UTC 2021

Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.

Reproductive toxicology (Elmsford, N.Y.)

Lei F,Wang W,Fu Y,Wang J,Zheng Y

Mon Mar 01 00:00:00 UTC 2021

Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.

Food & function

Xu Q,Fan Y,Loor JJ,Liang Y,Lv H,Sun X,Jia H,Xu C

Thu Jan 21 00:00:00 UTC 2021

Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.

Molecules (Basel, Switzerland)

Bai Y,Wang W,Wang L,Ma L,Zhai D,Wang F,Shi R,Liu C,Xu Q,Chen G,Lu Z

Sat Jan 09 00:00:00 UTC 2021

Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.

International immunopharmacology

Wang L,Wang X,Kong L,Wang S,Huang K,Wu J,Wang C,Sun H,Liu K,Meng Q

Mon Nov 01 00:00:00 UTC 2021

Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.

Life sciences

Ge PX,Jiang LP,Tai T,Zhu T,Ji JZ,Li YF,Mi QY,Xie HG

Sun Aug 15 00:00:00 UTC 2021

Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.

Frontiers in cellular and infection microbiology

Yang S,Deng Q,Sun L,Zhu Y,Dong K,Wu S,Huang R,Li Y

Mon Jul 05 00:00:00 UTC 2021

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.

EMBO reports

Tan CT,Chang HC,Zhou Q,Yu C,Fu NY,Sabapathy K,Yu VC

Thu Jan 07 00:00:00 UTC 2021

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.

EMBO reports

Tan CT,Chang HC,Zhou Q,Yu C,Fu NY,Sabapathy K,Yu VC

Thu Jan 07 00:00:00 UTC 2021

Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.

Molecular medicine reports

Liu M,Zheng B,Liu P,Zhang J,Chu X,Dong C,Shi J,Liang Y,Chu L,Liu Y,Han X

Tue Jun 01 00:00:00 UTC 2021

Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.

Cell death & disease

Feng L,Chen M,Li Y,Li M,Hu S,Zhou B,Zhu L,Yu L,Zhou Q,Tan L,An H,Wang X,Jin H

Wed Apr 14 00:00:00 UTC 2021

P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.

Biochemical pharmacology

Ji JZ,Li YF,Jiang LP,Tai T,Ge PX,Mi QY,Zhu T,Xie HG

Fri Jan 01 00:00:00 UTC 2021

Coordinate regulation of the senescent state by selective autophagy.

Developmental cell

Lee Y,Kim J,Kim MS,Kwon Y,Shin S,Yi H,Kim H,Chang MJ,Chang CB,Kang SB,Kim VN,Kim JH,Kim JS,Elledge SJ,Kang C

Mon May 17 00:00:00 UTC 2021

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets.

Frontiers in microbiology

Wang M,Huang H,Wang L,Yang H,He S,Liu F,Tu Q,He S

Fri Nov 03 00:00:00 UTC 2023

Sinomenine protects bone from destruction to ameliorate arthritis via activating p62^{Thr269/Ser272}-Keap1-Nrf2 feedback loop.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liao K,Su X,Lei K,Liu Z,Lu L,Wu Q,Pan H,Huang Q,Zhao Y,Wang M,Cai J,Liu L,Li T

Mon Mar 01 00:00:00 UTC 2021

Physical plasma-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death.

Free radical biology & medicine

Kumar N,Perez-Novo C,Shaw P,Logie E,Privat-Maldonado A,Dewilde S,Smits E,Berghe WV,Bogaerts A

Thu Apr 01 00:00:00 UTC 2021

Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.

Ecotoxicology and environmental safety

Li S,Wang X,Xiao Y,Wang Y,Wan Y,Li X,Li Q,Tang X,Cai D,Ran B,Wu C

Fri Jan 15 00:00:00 UTC 2021

STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sitthideatphaiboon P,Galan-Cobo A,Negrao MV,Qu X,Poteete A,Zhang F,Liu DD,Lewis WE,Kemp HN,Lewis J,Rinsurongkawong W,Giri U,Lee JJ,Zhang J,Roth JA,Swisher S,Heymach JV

Mon Mar 15 00:00:00 UTC 2021

Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription.

Journal of immunology (Baltimore, Md. : 1950)

Burns VE,Kerppola TK

Wed Sep 01 00:00:00 UTC 2021

Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.

Journal of inflammation research

Chen D,Gao ZQ,Wang YY,Wan BB,Liu G,Chen JL,Wu YX,Zhou Q,Jiang SY,Yu RQ,Pang QF

Thu Apr 21 00:00:00 UTC 2022

Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.

Frontiers in nutrition

Li X,Gao M,Zhu S,Yin L,Zhang B,Qi Y,Zhao Y,Yu Y,Xu L

Tue Jun 15 00:00:00 UTC 2021

Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.

Phytochemistry

Song Z,Gao C,Jiang Q,Xu J,Xiong L,Liu K,Sun D,Li H,Chen L

Wed Dec 01 00:00:00 UTC 2021

Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.

European journal of pharmacology

Li R,Qi Y,Yuan Q,Xu L,Gao M,Xu Y,Han X,Yin L,Liu C

Wed Sep 15 00:00:00 UTC 2021

Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.

Journal of drug targeting

Peng J,Jiang Z,Wu G,Cai Z,Du Q,Tao L,Zhang Y,Chen Y,Shen X

Tue Jun 01 00:00:00 UTC 2021

Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.

Journal of drug targeting

Peng J,Jiang Z,Wu G,Cai Z,Du Q,Tao L,Zhang Y,Chen Y,Shen X

Tue Jun 01 00:00:00 UTC 2021

Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.

Oxidative medicine and cellular longevity

Yang F,He X,Chen T,Liu J,Luo Z,Sun S,Qin D,Huang W,Tang Y,Liu C,Luo F

Fri Mar 04 00:00:00 UTC 2022

Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.

Free radical biology & medicine

Hong J,Shi Z,Li C,Ji X,Li S,Chen Y,Jiang G,Shi M,Wang W,Zhang Y,Hu B,Yan S

Sun Aug 01 00:00:00 UTC 2021

Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.

Free radical biology & medicine

Hong J,Shi Z,Li C,Ji X,Li S,Chen Y,Jiang G,Shi M,Wang W,Zhang Y,Hu B,Yan S

Sun Aug 01 00:00:00 UTC 2021

Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.

Journal of agricultural and food chemistry

Xing Y,Ren X,Li X,Sui L,Shi X,Sun Y,Quan C,Xiu Z,Dong Y

Wed Sep 01 00:00:00 UTC 2021

(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.

Toxicology and applied pharmacology

Tian X,Xue Y,Xie G,Zhou Y,Xiao H,Ding F,Zhang M

Fri Oct 15 00:00:00 UTC 2021

Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.

Chemistry & biodiversity

Zhang K,Fang KL,Wang T,Xu LT,Zhao Y,Wang XN,Xiang L,Shen T

Mon Nov 01 00:00:00 UTC 2021

Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351.

Scientific reports

Park JY,Sohn HY,Koh YH,Jo C

Mon Apr 19 00:00:00 UTC 2021

Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.

Antioxidants (Basel, Switzerland)

Chen YS,Chang HS,Hsiao HH,Chen YF,Kuo YP,Yen FL,Yen CH

Thu Apr 01 00:00:00 UTC 2021

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.

Nature communications

Kageyama S,Gudmundsson SR,Sou YS,Ichimura Y,Tamura N,Kazuno S,Ueno T,Miura Y,Noshiro D,Abe M,Mizushima T,Miura N,Okuda S,Motohashi H,Lee JA,Sakimura K,Ohe T,Noda NN,Waguri S,Eskelinen EL,Komatsu M

Mon Jan 04 00:00:00 UTC 2021

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.

Nature communications

Kageyama S,Gudmundsson SR,Sou YS,Ichimura Y,Tamura N,Kazuno S,Ueno T,Miura Y,Noshiro D,Abe M,Mizushima T,Miura N,Okuda S,Motohashi H,Lee JA,Sakimura K,Ohe T,Noda NN,Waguri S,Eskelinen EL,Komatsu M

Mon Jan 04 00:00:00 UTC 2021

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.

Nature communications

Kageyama S,Gudmundsson SR,Sou YS,Ichimura Y,Tamura N,Kazuno S,Ueno T,Miura Y,Noshiro D,Abe M,Mizushima T,Miura N,Okuda S,Motohashi H,Lee JA,Sakimura K,Ohe T,Noda NN,Waguri S,Eskelinen EL,Komatsu M

Mon Jan 04 00:00:00 UTC 2021

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.

Nature communications

Kageyama S,Gudmundsson SR,Sou YS,Ichimura Y,Tamura N,Kazuno S,Ueno T,Miura Y,Noshiro D,Abe M,Mizushima T,Miura N,Okuda S,Motohashi H,Lee JA,Sakimura K,Ohe T,Noda NN,Waguri S,Eskelinen EL,Komatsu M

Mon Jan 04 00:00:00 UTC 2021

Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.

Journal of dairy science

Xu Q,Fan Y,Loor JJ,Liang Y,Sun X,Jia H,Zhao C,Xu C

Thu Apr 01 00:00:00 UTC 2021

Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.

Journal of agricultural and food chemistry

Zhao Y,Lu J,Mao A,Zhang R,Guan S

Wed Aug 25 00:00:00 UTC 2021

Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.

Aging

Yang RZ,Zheng HL,Xu WN,Zheng XF,Li B,Jiang LS,Jiang SD

Mon Feb 01 00:00:00 UTC 2021

Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.

Cells

Hori Y,Tsutsumi R,Nasu K,Boateng A,Ashikari Y,Sugiura M,Nakajima M,Kurauchi Y,Hisatsune A,Katsuki H,Seki T

Mon May 03 00:00:00 UTC 2021

Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.

Journal of ethnopharmacology

Zhang M,Zhang T,Song C,Qu J,Gu Y,Liu S,Li H,Xiao W,Kong L,Sun Y,Lv W

Mon Jun 28 00:00:00 UTC 2021

Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.

Medical molecular morphology

Honma Y,Miyagawa K,Hara Y,Hayashi T,Kusanaga M,Ogino N,Minami S,Oe S,Ikeda M,Hino K,Harada M

Tue Jun 01 00:00:00 UTC 2021

Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis.

Pesticide biochemistry and physiology

Zhou L,Chang J,Zhao W,Gao Y

Sun Aug 01 00:00:00 UTC 2021

Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.

Cell death & disease

Kong L,Deng J,Zhou X,Cai B,Zhang B,Chen X,Chen Z,Wang W

Mon Oct 11 00:00:00 UTC 2021

RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.

Cell death & disease

Feng X,Jiang T,Yang C,Pang S,Ding Z,Hu H,Wang H,Dong L,Yang N

Fri Dec 17 00:00:00 UTC 2021

RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.

Cell death & disease

Feng X,Jiang T,Yang C,Pang S,Ding Z,Hu H,Wang H,Dong L,Yang N

Fri Dec 17 00:00:00 UTC 2021

Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.

Cell and tissue research

Cui Q,Yan L

Mon Nov 01 00:00:00 UTC 2021

Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.

Journal of agricultural and food chemistry

Yuan J,Che S,Zhang L,Ruan Z

Wed Apr 14 00:00:00 UTC 2021

Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.

Nanotoxicology

Zhang L,Zou L,Jiang X,Cheng S,Zhang J,Qin X,Qin Z,Chen C,Zou Z

Sun Aug 01 00:00:00 UTC 2021

Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.

Cells

Ying YT,Yang J,Tan X,Liu R,Zhuang Y,Xu JX,Ren WJ

Mon Dec 06 00:00:00 UTC 2021

Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.

Naunyn-Schmiedeberg's archives of pharmacology

Rahim I,Sayed RK,Fernández-Ortiz M,Aranda-Martínez P,Guerra-Librero A,Fernández-Martínez J,Rusanova I,Escames G,Djerdjouri B,Acuña-Castroviejo D

Mon Feb 01 00:00:00 UTC 2021

CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.

Pharmacological research

Yang Y,Li J,Zhang L,Lin Z,Xiao H,Sun X,Zhang M,Liu P,Huang H

Fri Jan 01 00:00:00 UTC 2021

Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.

Food chemistry

Wang Y,Jin R,Chen J,Cao J,Xiao J,Li X,Sun C

Wed Dec 15 00:00:00 UTC 2021

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.

Neurobiology of aging

Guo C,Zhang Y,Nie Q,Cao D,Wang X,Wan X,Liu M,Cui J,Sun J,Bai Y,Li L

Mon Feb 01 00:00:00 UTC 2021

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.

Neurobiology of aging

Guo C,Zhang Y,Nie Q,Cao D,Wang X,Wan X,Liu M,Cui J,Sun J,Bai Y,Li L

Mon Feb 01 00:00:00 UTC 2021

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.

Neurobiology of aging

Guo C,Zhang Y,Nie Q,Cao D,Wang X,Wan X,Liu M,Cui J,Sun J,Bai Y,Li L

Mon Feb 01 00:00:00 UTC 2021

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.

Neurobiology of aging

Guo C,Zhang Y,Nie Q,Cao D,Wang X,Wan X,Liu M,Cui J,Sun J,Bai Y,Li L

Mon Feb 01 00:00:00 UTC 2021

Nicotinamide improves NAD⁺ levels to protect against acetaminophen-induced acute liver injury in mice.

Human & experimental toxicology

Xu J,Zhang L,Jiang R,Hu K,Hu D,Liao C,Jiang S,Yang Y,Huang J,Tang L,Li L

Mon Nov 01 00:00:00 UTC 2021

Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM_2.5.

Frontiers in endocrinology

Shi F,Zhang Z,Wang J,Wang Y,Deng J,Zeng Y,Zou P,Ling X,Han F,Liu J,Ao L,Cao J

Fri Mar 18 00:00:00 UTC 2022

Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.

Oxidative medicine and cellular longevity

Peng W,Wan L,Luo Z,Xie Y,Liu Y,Huang T,Lu H,Hu J

Mon Jan 31 00:00:00 UTC 2022

The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang M,Ke Y,Li Y,Shan Z,Mi W,Cao Y,Feng W,Zheng X

Tue Jun 01 00:00:00 UTC 2021

NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.

Cell reports

Joshi CS,Mora A,Felder PA,Mysorekar IU

Tue Oct 19 00:00:00 UTC 2021

NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.

Cell reports

Joshi CS,Mora A,Felder PA,Mysorekar IU

Tue Oct 19 00:00:00 UTC 2021

NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.

Cell reports

Joshi CS,Mora A,Felder PA,Mysorekar IU

Tue Oct 19 00:00:00 UTC 2021

The piperine derivative HJ105 inhibits Aβ_1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yang X,Zhi J,Leng H,Chen Y,Gao H,Ma J,Ji J,Hu Q

Thu Jul 01 00:00:00 UTC 2021

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells.

Cell stress & chaperones

Zhang H,Ge F,Shui X,Xiang Y,Wang X,Liao C,Wang J

Sat May 01 00:00:00 UTC 2021

Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.

Cell death discovery

Wang W,Zhai D,Bai Y,Xue K,Deng L,Ma L,Du T,Ye Z,Qu D,Xiang A,Chen G,Zhao Y,Wang L,Lu Z

Tue Mar 23 00:00:00 UTC 2021

Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.

Cell death discovery

Wang W,Zhai D,Bai Y,Xue K,Deng L,Ma L,Du T,Ye Z,Qu D,Xiang A,Chen G,Zhao Y,Wang L,Lu Z

Tue Mar 23 00:00:00 UTC 2021

Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.

Ecotoxicology and environmental safety

Zhao G,Qi L,Wang Y,Li X,Li Q,Tang X,Wang X,Wu C

Fri Oct 01 00:00:00 UTC 2021

Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yuan J,Che S,Ruan Z,Song L,Tang R,Zhang L

Thu Apr 01 00:00:00 UTC 2021

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.

Free radical biology & medicine

Ma WQ,Sun XJ,Zhu Y,Liu NF

Mon Mar 01 00:00:00 UTC 2021

Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.

Ecotoxicology and environmental safety

Ma Y,Li S,Ye S,Tang S,Hu D,Wei L,Xiao F

Fri Oct 15 00:00:00 UTC 2021

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin.

EBioMedicine

Hou K,Shen J,Yan J,Zhai C,Zhang J,Pan JA,Zhang Y,Jiang Y,Wang Y,Lin RZ,Cong H,Gao S,Zong WX

Thu Jul 01 00:00:00 UTC 2021

Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.

Theranostics

Cheng Y,Cheng L,Gao X,Chen S,Wu P,Wang C,Liu Z

Wed Aug 04 00:00:00 UTC 2021

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 UTC 2022

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 UTC 2022

Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.

Bioengineered

Deng J,Huang M,Wu H

Wed Dec 01 00:00:00 UTC 2021

Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.

Journal of agricultural and food chemistry

Li D,Hu Z,He Q,Guo Y,Chong Y,Xu J,Qin L

Wed Dec 15 00:00:00 UTC 2021

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.

Autophagy

Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z

Fri May 01 00:00:00 UTC 2020

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.

Autophagy

Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z

Fri May 01 00:00:00 UTC 2020

Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.

Biochemical and biophysical research communications

Qin X,Hua J,Lin SJ,Zheng HT,Wang JJ,Li W,Ke JJ,Cai HB

Tue Oct 20 00:00:00 UTC 2020

Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.

Chemico-biological interactions

Fan Y,Xing Y,Xiong L,Wang J

Mon Jun 01 00:00:00 UTC 2020

Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.

BioMed research international

Du J,He W,Zhang C,Wu J,Li Z,Wang M,Feng S,Liang G

Mon Nov 23 00:00:00 UTC 2020

Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.

IUBMB life

Zhou H,Yuan D,Gao W,Tian J,Sun H,Yu S,Wang J,Sun L

Sat Aug 01 00:00:00 UTC 2020

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.

PloS one

Seo HY,Lee SH,Lee JH,Hwang JS,Kim MK,Jang BK

Fri Dec 04 00:00:00 UTC 2020

High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.

Acta biochimica et biophysica Sinica

Chen X,Qi J,Wu Q,Jiang H,Wang J,Chen W,Mao A,Zhu M

Tue May 26 00:00:00 UTC 2020

Normobaric hyperoxia plays a protective role against renal ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway.

Biochemical and biophysical research communications

Pei J,Cai S,Song S,Xu Y,Feng M,Luo G,Wang Y,Sun F,Shi H,Xu S

Thu Oct 29 00:00:00 UTC 2020

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.

Cell death & disease

Wang M,Liu CY,Wang T,Yu HM,Ouyang SH,Wu YP,Gong HB,Ma XH,Jiao GL,Fu LL,Wu QS,Kurihara H,Li YF,Shen T,He RR

Sat Sep 19 00:00:00 UTC 2020

S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways.

International immunopharmacology

Mo M,Li S,Dong Z,Li C,Sun Y,Li A,Zhao Z

Wed Apr 01 00:00:00 UTC 2020

C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.

Frontiers in cell and developmental biology

Li J,Yang Q,Han L,Pan C,Lei C,Chen H,Lan X

Tue Oct 13 00:00:00 UTC 2020

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.

Autophagy

Park JS,Lee DH,Lee YS,Oh E,Bae KH,Oh KJ,Kim H,Bae SH

Wed Jan 01 00:00:00 UTC 2020

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.

Scientific reports

Jiang Z,Fu L,Xu Y,Hu X,Yang H,Zhang Y,Luo H,Gan S,Tao L,Liang G,Shen X

Tue Apr 14 00:00:00 UTC 2020

Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin.

Frontiers in immunology

Rahtes A,Li L

Mon Apr 19 00:00:00 UTC 2021

Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.

Animals : an open access journal from MDPI

Zhang L,Zhang J,Yan E,He J,Zhong X,Zhang L,Wang C,Wang T

Tue Mar 24 00:00:00 UTC 2020

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

Molecular cancer research : MCR

Song S,Nguyen V,Schrank T,Mulvaney K,Walter V,Wei D,Orvis T,Desai N,Zhang J,Hayes DN,Zheng Y,Major MB,Weissman BE

Tue Dec 01 00:00:00 UTC 2020

Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.

Brain research

Li Y,Wu J,Yu S,Zhu J,Zhou Y,Wang P,Li L,Zhao Y

Thu Oct 15 00:00:00 UTC 2020

BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.

Journal of experimental & clinical cancer research : CR

Liu JZ,Hu YL,Feng Y,Jiang Y,Guo YB,Liu YF,Chen X,Yang JL,Chen YY,Mao QS,Xue WJ

Tue Jun 30 00:00:00 UTC 2020

NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.

Nucleic acids research

Sun X,Wang Y,Ji K,Liu Y,Kong Y,Nie S,Li N,Hao J,Xie Y,Xu C,Du L,Liu Q

Fri Sep 18 00:00:00 UTC 2020

Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.

Meat science

Cheng K,Yu C,Li Z,Li S,Yan E,Song Z,Zhang H,Zhang L,Wang T

Tue Dec 01 00:00:00 UTC 2020

Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway.

International journal of molecular sciences

Guo W,Liu J,Li W,Ma H,Gong Q,Kan X,Cao Y,Wang J,Fu S

Fri May 08 00:00:00 UTC 2020

Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.

Journal of food biochemistry

Wang Z,Cai L,Li H,Liang M,Zhang Y,Wu Q,Yang L

Fri May 01 00:00:00 UTC 2020

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.

EMBO reports

Sánchez-Martín P,Sou YS,Kageyama S,Koike M,Waguri S,Komatsu M

Wed Mar 04 00:00:00 UTC 2020

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.

EMBO reports

Sánchez-Martín P,Sou YS,Kageyama S,Koike M,Waguri S,Komatsu M

Wed Mar 04 00:00:00 UTC 2020

The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma.

Cancers

Lee K,Kim S,Lee Y,Lee H,Lee Y,Park H,Nahm JH,Ahn S,Yu SJ,Lee K,Kim H

Fri Jul 31 00:00:00 UTC 2020

Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.

Evidence-based complementary and alternative medicine : eCAM

Zhu Q,Zeng J,Li J,Chen X,Miao J,Jin Q,Chen H

Mon Sep 28 00:00:00 UTC 2020

Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.

Evidence-based complementary and alternative medicine : eCAM

Zhu Q,Zeng J,Li J,Chen X,Miao J,Jin Q,Chen H

Mon Sep 28 00:00:00 UTC 2020

Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.

International journal of biological macromolecules

Zhang Y,Wang H,Zhang L,Yuan Y,Yu D

Sat Feb 15 00:00:00 UTC 2020

Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.

Cell communication and signaling : CCS

Xu A,Yang Y,Shao Y,Wu M,Sun Y

Wed Jan 15 00:00:00 UTC 2020

Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.

International journal of molecular sciences

Wang S,Cheng H,Wang L,Zhao R,Guan D

Mon Mar 16 00:00:00 UTC 2020

Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.

Cardiovascular toxicology

Nordgren KKS,Wallace KB

Tue Dec 01 00:00:00 UTC 2020

Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Zhang B,Yu D,Luo N,Yang C,Zhu Y

Tue Sep 01 00:00:00 UTC 2020

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.

European journal of medicinal chemistry

Lu MC,Shao HL,Liu T,You QD,Jiang ZY

Tue Dec 01 00:00:00 UTC 2020

The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.

Cell proliferation

Kang L,Liu S,Li J,Tian Y,Xue Y,Liu X

Sun Mar 01 00:00:00 UTC 2020

Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.

Frontiers in pharmacology

Xu Q,Fan Y,Loor JJ,Liang Y,Sun X,Jia H,Zhao C,Xu C

Thu Dec 31 00:00:00 UTC 2020

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.

Nature communications

Liu Y,Tao S,Liao L,Li Y,Li H,Li Z,Lin L,Wan X,Yang X,Chen L

Fri Jan 17 00:00:00 UTC 2020

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.

Nature communications

Liu Y,Tao S,Liao L,Li Y,Li H,Li Z,Lin L,Wan X,Yang X,Chen L

Fri Jan 17 00:00:00 UTC 2020

p62 Suppressed VK3-induced Oxidative Damage Through Keap1/Nrf2 Pathway In Human Ovarian Cancer Cells.

Journal of Cancer

Xia MH,Yan XY,Zhou L,Xu L,Zhang LC,Yi HW,Su J

Mon Sep 28 00:00:00 UTC 2020

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.

Cell death & disease

Liu H,Zhu Y,Gao Y,Qi D,Zhao L,Zhao L,Liu C,Tao T,Zhou C,Sun X,Guo F,Xiao J

Tue Feb 18 00:00:00 UTC 2020

Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.

Frontiers in pharmacology

Li C,Zhang S,Li L,Hu Q,Ji S

Fri Nov 13 00:00:00 UTC 2020

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.

Neuropharmacology

Kim S,Indu Viswanath AN,Park JH,Lee HE,Park AY,Choi JW,Kim HJ,Londhe AM,Jang BK,Lee J,Hwang H,Lim SM,Pae AN,Park KD

Fri May 01 00:00:00 UTC 2020

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.

Redox biology

Deng S,Essandoh K,Wang X,Li Y,Huang W,Chen J,Peng J,Jiang DS,Mu X,Wang C,Peng T,Guan JL,Wang Y,Jegga A,Huang K,Fan GC

Fri May 01 00:00:00 UTC 2020

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.

Redox biology

Deng S,Essandoh K,Wang X,Li Y,Huang W,Chen J,Peng J,Jiang DS,Mu X,Wang C,Peng T,Guan JL,Wang Y,Jegga A,Huang K,Fan GC

Fri May 01 00:00:00 UTC 2020

Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.

Oxidative medicine and cellular longevity

Qi J,Chen X,Wu Q,Wang J,Zhang H,Mao A,Zhu M,Miao C

Tue Nov 17 00:00:00 UTC 2020

Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.

Oxidative medicine and cellular longevity

Qi J,Chen X,Wu Q,Wang J,Zhang H,Mao A,Zhu M,Miao C

Tue Nov 17 00:00:00 UTC 2020

Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Iuchi K,Tasaki Y,Shirai S,Hisatomi H

Fri May 01 00:00:00 UTC 2020

SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.

Autophagy

Lee DH,Park JS,Lee YS,Han J,Lee DK,Kwon SW,Han DH,Lee YH,Bae SH

Sun Nov 01 00:00:00 UTC 2020

Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.

European journal of pharmacology

Yu Z,Yang L,Deng S,Liang M

Thu Oct 15 00:00:00 UTC 2020

Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.

Translational oncology

Lippmann J,Petri K,Fulda S,Liese J

Sat Aug 01 00:00:00 UTC 2020

Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.

Cell death & disease

Xu Q,Shi W,Lv P,Meng W,Mao G,Gong C,Chen Y,Wei Y,He X,Zhao J,Han H,Sun M,Xiao K

Thu Jan 02 00:00:00 UTC 2020

Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.

Cell death & disease

Xu Q,Shi W,Lv P,Meng W,Mao G,Gong C,Chen Y,Wei Y,He X,Zhao J,Han H,Sun M,Xiao K

Thu Jan 02 00:00:00 UTC 2020

The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D₃ Plus Nicotine.

Antioxidants (Basel, Switzerland)

Liou SF,Nguyen TTN,Hsu JH,Sulistyowati E,Huang SE,Wu BN,Lin MC,Yeh JL

Tue Oct 06 00:00:00 UTC 2020

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.

BMC complementary medicine and therapies

Xie D,Jiang L,Lin Y,Liu Z

Thu Aug 27 00:00:00 UTC 2020

4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.

American journal of translational research

Wei X,Wang H,Sun X,Huang X,Xu W,Liang Y,Liu L,Mo S,Lin X,Lin J

Mon Sep 28 00:00:00 UTC 2020

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.

Molecular neurobiology

Sun Y,He L,Wang T,Hua W,Qin H,Wang J,Wang L,Gu W,Li T,Li N,Liu X,Chen F,Tang L

Sun Nov 01 00:00:00 UTC 2020

Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.

Experimental and therapeutic medicine

Du J,Zhu M,Li H,Liang G,Li Y,Feng S

Sat Aug 01 00:00:00 UTC 2020

Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.

Oncology reports

Li M,Liu P,Xue Y,Liang Y,Shi J,Han X,Zhang J,Chu X,Chu L

Sun Nov 01 00:00:00 UTC 2020

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.

Biomaterials

Wang T,Jian Z,Baskys A,Yang J,Li J,Guo H,Hei Y,Xian P,He Z,Li Z,Li N,Long Q

Thu Oct 01 00:00:00 UTC 2020

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.

Science translational medicine

Lu Y,Sun Y,Liu Z,Lu Y,Zhu X,Lan B,Mi Z,Dang L,Li N,Zhan W,Tan L,Pi J,Xiong H,Zhang L,Chen Y

Wed Jul 29 00:00:00 UTC 2020

Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy.

Cells

Lin DS,Ho CS,Huang YW,Wu TY,Lee TH,Huang ZD,Wang TJ,Yang SJ,Chiang MF

Fri May 01 00:00:00 UTC 2020

Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-B Pathway.

The American journal of Chinese medicine

Wu J,Yang CL,Sha YK,Wu Y,Liu ZY,Yuan ZH,Sun ZL

Fri Sep 04 00:00:00 UTC 2020

Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li GH,Li AL,Chen XM,Zhang LY,Wang T,Wang XN,Shen T

Wed Jan 01 00:00:00 UTC 2020

LncRNA MALAT1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway.

Oxidative medicine and cellular longevity

Ye W,Ma J,Wang F,Wu T,He M,Li J,Pei R,Zhang L,Wang Y,Zhou J

Thu May 20 00:00:00 UTC 2021

The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.

Cell reports

Toulis V,García-Monclús S,de la Peña-Ramírez C,Arenas-Galnares R,Abril JF,Todi SV,Khan N,Garanto A,Costa MDC,Marfany G

Tue Nov 10 00:00:00 UTC 2020

Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.

Aging

Ding S,Ma N,Liu H,Tang M,Mei J

Tue Nov 24 00:00:00 UTC 2020

NRF2-Driven KEAP1 Transcription in Human Lung Cancer.

Molecular cancer research : MCR

Tian Y,Liu Q,Yu S,Chu Q,Chen Y,Wu K,Wang L

Thu Oct 01 00:00:00 UTC 2020

Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.

Toxins

Sun Y,Wu Y,Wang Z,Chen J,Yang Y,Dong G

Sat Aug 01 00:00:00 UTC 2020

Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.

Antioxidants (Basel, Switzerland)

Sun B,Wang X,Liu X,Wang L,Ren F,Wang X,Leng X

Tue Aug 25 00:00:00 UTC 2020

PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.

Cell death & disease

Ma WQ,Sun XJ,Zhu Y,Liu NF

Tue Nov 17 00:00:00 UTC 2020

Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.

Journal of medicinal food

Li H,Liang M,Wang Z,Zhang Y,Wu Q,Yang L

Mon Jun 01 00:00:00 UTC 2020

Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.

Molecular medicine reports

Li R,Xiao J,Tang S,Lin X,Xu H,Han B,Yang M,Liu F

Tue Sep 01 00:00:00 UTC 2020

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.

International immunopharmacology

Yang X,Ji J,Liu C,Zhou M,Li H,Ye S,Hu Q

Mon Jun 01 00:00:00 UTC 2020

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.

Science signaling

Hayashi M,Guida E,Inokawa Y,Goldberg R,Reis LO,Ooki A,Pilli M,Sadhukhan P,Woo J,Choi W,Izumchenko E,Gonzalez LM,Marchionni L,Zhavoronkov A,Brait M,Bivalacqua T,Baras A,Netto GJ,Koch W,Singh A,Hoque MO

Tue Aug 18 00:00:00 UTC 2020

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.

Science signaling

Tue Aug 18 00:00:00 UTC 2020

Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.

Journal of agricultural and food chemistry

Wang C,Zheng L,Su G,Zeng XA,Sun B,Zhao M

Wed Feb 26 00:00:00 UTC 2020

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

Cancer cell

Karras P,Riveiro-Falkenbach E,Cañón E,Tejedo C,Calvo TG,Martínez-Herranz R,Alonso-Curbelo D,Cifdaloz M,Perez-Guijarro E,Gómez-López G,Ximenez-Embun P,Muñoz J,Megias D,Olmeda D,Moscat J,Ortiz-Romero PL,Rodríguez-Peralto JL,Soengas MS

Mon Jan 14 00:00:00 UTC 2019

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

Cancer cell

Mon Jan 14 00:00:00 UTC 2019

Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

American journal of hematology

Beneduce E,Matte A,De Falco L,Mbiandjeu S,Chiabrando D,Tolosano E,Federti E,Petrillo S,Mohandas N,Siciliano A,Babu W,Menon V,Ghaffari S,Iolascon A,De Franceschi L

Tue Jan 01 00:00:00 UTC 2019

Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

American journal of hematology

Beneduce E,Matte A,De Falco L,Mbiandjeu S,Chiabrando D,Tolosano E,Federti E,Petrillo S,Mohandas N,Siciliano A,Babu W,Menon V,Ghaffari S,Iolascon A,De Franceschi L

Tue Jan 01 00:00:00 UTC 2019

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.

Stem cells (Dayton, Ohio)

Zuo R,Wang Y,Li J,Wu J,Wang W,Li B,Sun C,Wang Z,Shi C,Zhou Y,Liu M,Zhang C

Sat Jun 01 00:00:00 UTC 2019

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.

Frontiers in aging neuroscience

Haytural H,Lundgren JL,Köse TB,Jordà-Siquier T,Kalcheva M,Seed Ahmed M,Winblad B,Sundström E,Barthet G,Tjernberg LO,Frykman S

Wed Sep 30 00:00:00 UTC 2020

Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.

Phytochemistry

Qiao YN,Sun Y,Shen T,Zhang JZ,Zhou JC,Li Y,Chen W,Ren ZJ,Li YL,Wang X,Lou HX

Fri Feb 01 00:00:00 UTC 2019

Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.

Phytochemistry

Qiao YN,Sun Y,Shen T,Zhang JZ,Zhou JC,Li Y,Chen W,Ren ZJ,Li YL,Wang X,Lou HX

Fri Feb 01 00:00:00 UTC 2019

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 UTC 2019

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 UTC 2019

Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.

The Journal of reproduction and development

Ullah O,Li Z,Ali I,Xu L,Liu H,Shah SZA,Fang N

Fri Feb 08 00:00:00 UTC 2019

Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.

The Journal of reproduction and development

Ullah O,Li Z,Ali I,Xu L,Liu H,Shah SZA,Fang N

Fri Feb 08 00:00:00 UTC 2019

l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.

Journal of the science of food and agriculture

Wang Z,Liang M,Li H,Cai L,He H,Wu Q,Yang L

Thu Aug 15 00:00:00 UTC 2019

Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.

Theranostics

Xian P,Hei Y,Wang R,Wang T,Yang J,Li J,Di Z,Liu Z,Baskys A,Liu W,Wu S,Long Q

Mon Aug 31 00:00:00 UTC 2020

MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.

Pharmacological research

Zhao X,Jin Y,Li L,Xu L,Tang Z,Qi Y,Yin L,Peng J

Thu Aug 01 00:00:00 UTC 2019

Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.

Cells

Xu B,Lang LM,Li SZ,Guo JR,Wang JF,Wang D,Zhang LP,Yang HM,Lian S

Tue Jun 18 00:00:00 UTC 2019

Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.

Journal of medicinal chemistry

Lu MC,Zhang X,Wu F,Tan SJ,Zhao J,You QD,Jiang ZY

Thu Jul 25 00:00:00 UTC 2019

MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats.

American journal of physiology. Cell physiology

Kukoyi AT,Fan X,Staitieh BS,Hybertson BM,Gao B,McCord JM,Guidot DM

Thu Aug 01 00:00:00 UTC 2019

Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.

Free radical biology & medicine

Park JS,Lee YS,Lee DH,Bae SH

Sat Jun 01 00:00:00 UTC 2019

S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.

Free radical biology & medicine

Tocmo R,Parkin K

Fri Nov 01 00:00:00 UTC 2019

Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.

Brain sciences

Xu B,Lang LM,Lian S,Guo JR,Wang JF,Yang HM,Li SZ

Sat Oct 12 00:00:00 UTC 2019

Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.

ACS chemical neuroscience

Yan J,Pang Y,Zhuang J,Lin H,Zhang Q,Han L,Ke P,Zhuang J,Huang X

Wed Jun 19 00:00:00 UTC 2019

Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.

Journal of the science of food and agriculture

Liang M,Li H,Wang Z,Cai L,Yang L

Tue Oct 01 00:00:00 UTC 2019

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Nature communications

Wang Z,Chen Z,Jiang Z,Luo P,Liu L,Huang Y,Wang H,Wang Y,Long L,Tan X,Liu D,Jin T,Wang Y,Wang Y,Liao F,Zhang C,Chen L,Gan Y,Liu Y,Yang F,Huang C,Miao H,Chen J,Cheng T,Fu X,Shi C

Mon Jun 10 00:00:00 UTC 2019

Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Thu Aug 01 00:00:00 UTC 2019

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.

International journal of molecular sciences

Sparaneo A,Fabrizio FP,la Torre A,Graziano P,Di Maio M,Fontana A,Bisceglia M,Rossi A,Pizzolitto S,De Maglio G,Tancredi A,Grimaldi F,Balsamo T,Centra F,Manzorra MC,Trombetta D,Pantalone A,Bonfitto A,Maiello E,Fazio VM,Muscarella LA

Thu May 23 00:00:00 UTC 2019

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.

International journal of molecular sciences

Thu May 23 00:00:00 UTC 2019

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.

ACS chemical neuroscience

Wang H,Wei W,Lan X,Liu N,Li Y,Ma H,Sun T,Peng X,Zhuang C,Yu J

Wed May 15 00:00:00 UTC 2019

The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.

Oncogene

Zhou XL,Zhu CY,Wu ZG,Guo X,Zou W

Wed May 01 00:00:00 UTC 2019

Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.

Medical science monitor : international medical journal of experimental and clinical research

Yang Y,Chen S,Tao L,Gan S,Luo H,Xu Y,Shen X

Sat Jul 20 00:00:00 UTC 2019

Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.

Oxidative medicine and cellular longevity

Yan X,Fu X,Jia Y,Ma X,Tao J,Yang T,Ma H,Liang X,Liu X,Yang J,Wei J

Fri Dec 13 00:00:00 UTC 2019

Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.

Journal of agricultural and food chemistry

Jia YN,Peng YL,Zhao YP,Cheng XF,Zhou Y,Chai CL,Zeng LS,Pan MH,Xu L

Wed May 15 00:00:00 UTC 2019

Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.

Neurochemical research

Betharia S,Rondόn-Ortiz AN,Brown DA

Thu Aug 01 00:00:00 UTC 2019

TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.

Acta biochimica et biophysica Sinica

Zhang B,Wu J,Cai Y,Luo M,Wang B,Gu Y

Mon Apr 01 00:00:00 UTC 2019

Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.

Chemico-biological interactions

Wu XY,Chen XM,Zhou MX,Hu HX,Zhang JZ,Wang XN,Ren DM,Lou HX,Shen T

Sun Sep 01 00:00:00 UTC 2019

NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

Cancer letters

Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

Wed Aug 28 00:00:00 UTC 2019

NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

Cancer letters

Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

Wed Aug 28 00:00:00 UTC 2019

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.

Cell

Ast T,Meisel JD,Patra S,Wang H,Grange RMH,Kim SH,Calvo SE,Orefice LL,Nagashima F,Ichinose F,Zapol WM,Ruvkun G,Barondeau DP,Mootha VK

Thu May 30 00:00:00 UTC 2019

Neuroprotective Effect of Dioscin on the Aging Brain.

Molecules (Basel, Switzerland)

Qi Y,Li R,Xu L,Yin L,Xu Y,Han X,Peng J

Sat Mar 30 00:00:00 UTC 2019

HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.

The Journal of biological chemistry

Hu T,Schreiter FC,Bagchi RA,Tatman PD,Hannink M,McKinsey TA

Fri May 24 00:00:00 UTC 2019

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.

Evidence-based complementary and alternative medicine : eCAM

Peng C,Zhou ZM,Li J,Luo Y,Zhou YS,Ke XH,Huang KE

Wed Sep 30 00:00:00 UTC 2020

(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.

Free radical research

Li Y,Ma S,Zhang Y,Yao M,Zhu X,Guan F

Thu Aug 01 00:00:00 UTC 2019

Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.

BioMed research international

Liu S,Xu S,Wei R,Cui Z,Wu X,Wei R,Xie L,Zhou Y,Li W,Chen W

Wed Apr 01 00:00:00 UTC 2020

Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.

Journal of neuroinflammation

Zhang B,Wang G,He J,Yang Q,Li D,Li J,Zhang F

Mon Apr 22 00:00:00 UTC 2019

A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.

Chembiochem : a European journal of chemical biology

Hirose H,Hideshima T,Katoh T,Suga H

Fri Aug 16 00:00:00 UTC 2019

p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yamada M,Iwata M,Warabi E,Oishi H,Lira VA,Okutsu M

Mon Jul 01 00:00:00 UTC 2019

Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.

Cellular and molecular neurobiology

Bao F,Tao L,Zhang H

Fri Nov 01 00:00:00 UTC 2019

Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.

Free radical biology & medicine

Li AL,Shen T,Wang T,Zhou MX,Wang B,Song JT,Zhang PL,Wang XL,Ren DM,Lou HX,Wang XN

Sun Sep 01 00:00:00 UTC 2019

MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.

Atherosclerosis

Zhang J,Cai W,Fan Z,Yang C,Wang W,Xiong M,Ma C,Yang J

Fri Nov 01 00:00:00 UTC 2019

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Cell

Lignitto L,LeBoeuf SE,Homer H,Jiang S,Askenazi M,Karakousi TR,Pass HI,Bhutkar AJ,Tsirigos A,Ueberheide B,Sayin VI,Papagiannakopoulos T,Pagano M

Thu Jul 11 00:00:00 UTC 2019

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Nature communications

Wang P,Geng J,Gao J,Zhao H,Li J,Shi Y,Yang B,Xiao C,Linghu Y,Sun X,Chen X,Hong L,Qin F,Li X,Yu JS,You H,Yuan Z,Zhou D,Johnson RL,Chen L

Thu Feb 14 00:00:00 UTC 2019

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Nature communications

Wang P,Geng J,Gao J,Zhao H,Li J,Shi Y,Yang B,Xiao C,Linghu Y,Sun X,Chen X,Hong L,Qin F,Li X,Yu JS,You H,Yuan Z,Zhou D,Johnson RL,Chen L

Thu Feb 14 00:00:00 UTC 2019

The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages.

Parasite immunology

Pang Y,Zhang Z,Chen Y,Cao S,Yang X,Jia H

Wed May 01 00:00:00 UTC 2019

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.

Nature communications

Shi Y,Fan S,Wu M,Zuo Z,Li X,Jiang L,Shen Q,Xu P,Zeng L,Zhou Y,Huang Y,Yang Z,Zhou J,Gao J,Zhou H,Xu S,Ji H,Shi P,Wu DD,Yang C,Chen Y

Fri Oct 25 00:00:00 UTC 2019

An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.

Free radical research

Yang WJ,He JX,Zhou MX,Huang M,Wang SQ,Wang XN,Lou HX,Ren DM,Shen T

Fri Mar 01 00:00:00 UTC 2019

Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.

Frontiers in pharmacology

Song S,Chu L,Liang H,Chen J,Liang J,Huang Z,Zhang B,Chen X

Thu Oct 01 00:00:00 UTC 2020

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

Nature

Chen J,Ou Y,Yang Y,Li W,Xu Y,Xie Y,Liu Y

Tue May 01 00:00:00 UTC 2018

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

Nature

Chen J,Ou Y,Yang Y,Li W,Xu Y,Xie Y,Liu Y

Tue May 01 00:00:00 UTC 2018

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Cancer discovery

Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ

Thu Nov 01 00:00:00 UTC 2018

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Cancer discovery

Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ

Thu Nov 01 00:00:00 UTC 2018

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Cancer discovery

Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ

Thu Nov 01 00:00:00 UTC 2018

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Cancer discovery

Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ

Thu Nov 01 00:00:00 UTC 2018

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.

Cell metabolism

Yamada T,Murata D,Adachi Y,Itoh K,Kameoka S,Igarashi A,Kato T,Araki Y,Huganir RL,Dawson TM,Yanagawa T,Okamoto K,Iijima M,Sesaki H

Tue Oct 02 00:00:00 UTC 2018

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.

Cell metabolism

Yamada T,Murata D,Adachi Y,Itoh K,Kameoka S,Igarashi A,Kato T,Araki Y,Huganir RL,Dawson TM,Yanagawa T,Okamoto K,Iijima M,Sesaki H

Tue Oct 02 00:00:00 UTC 2018

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.

Nature cell biology

An H,Harper JW

Thu Feb 01 00:00:00 UTC 2018

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.

Nature cell biology

An H,Harper JW

Thu Feb 01 00:00:00 UTC 2018

Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.

Molecular cell

Zhao D,Badur MG,Luebeck J,Magaña JH,Birmingham A,Sasik R,Ahn CS,Ideker T,Metallo CM,Mali P

Thu Feb 15 00:00:00 UTC 2018

Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.

Molecular cell

Zhao D,Badur MG,Luebeck J,Magaña JH,Birmingham A,Sasik R,Ahn CS,Ideker T,Metallo CM,Mali P

Thu Feb 15 00:00:00 UTC 2018

dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.

Cell proliferation

Hu Q,Qin Y,Xiang J,Liu W,Xu W,Sun Q,Ji S,Liu J,Zhang Z,Ni Q,Xu J,Yu X,Zhang B

Wed Aug 01 00:00:00 UTC 2018

dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.

Cell proliferation

Hu Q,Qin Y,Xiang J,Liu W,Xu W,Sun Q,Ji S,Liu J,Zhang Z,Ni Q,Xu J,Yu X,Zhang B

Wed Aug 01 00:00:00 UTC 2018

CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.

Free radical biology & medicine

Gong W,Chen Z,Zou Y,Zhang L,Huang J,Liu P,Huang H

Thu Feb 01 00:00:00 UTC 2018

CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.

Free radical biology & medicine

Gong W,Chen Z,Zou Y,Zhang L,Huang J,Liu P,Huang H

Thu Feb 01 00:00:00 UTC 2018

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

Free radical biology & medicine

Shin D,Kim EH,Lee J,Roh JL

Sat Dec 01 00:00:00 UTC 2018

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

Free radical biology & medicine

Shin D,Kim EH,Lee J,Roh JL

Sat Dec 01 00:00:00 UTC 2018

Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.

Oxidative medicine and cellular longevity

Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T

Mon Oct 22 00:00:00 UTC 2018

Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.

Oxidative medicine and cellular longevity

Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T

Mon Oct 22 00:00:00 UTC 2018

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.

Acta pharmacologica Sinica

Li ST,Dai Q,Zhang SX,Liu YJ,Yu QQ,Tan F,Lu SH,Wang Q,Chen JW,Huang HQ,Liu PQ,Li M

Wed Aug 01 00:00:00 UTC 2018

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.

Acta pharmacologica Sinica

Li ST,Dai Q,Zhang SX,Liu YJ,Yu QQ,Tan F,Lu SH,Wang Q,Chen JW,Huang HQ,Liu PQ,Li M

Wed Aug 01 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.

European journal of medicinal chemistry

Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z

Sun Feb 25 00:00:00 UTC 2018

Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhou MM,Zhang WY,Li RJ,Guo C,Wei SS,Tian XM,Luo J,Kong LY

Thu Mar 15 00:00:00 UTC 2018

Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhou MM,Zhang WY,Li RJ,Guo C,Wei SS,Tian XM,Luo J,Kong LY

Thu Mar 15 00:00:00 UTC 2018

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.

Phytotherapy research : PTR

Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P

Sat Dec 01 00:00:00 UTC 2018

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.

Phytotherapy research : PTR

Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P

Sat Dec 01 00:00:00 UTC 2018

Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.

Food & function

Bi W,He CN,Li XX,Zhou LY,Liu RJ,Zhang S,Li GQ,Chen ZC,Zhang PF

Wed May 23 00:00:00 UTC 2018

Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.

Food & function

Bi W,He CN,Li XX,Zhou LY,Liu RJ,Zhang S,Li GQ,Chen ZC,Zhang PF

Wed May 23 00:00:00 UTC 2018

Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

International immunopharmacology

Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L

Thu Mar 01 00:00:00 UTC 2018

Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

International immunopharmacology

Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L

Thu Mar 01 00:00:00 UTC 2018

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 UTC 2018

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 UTC 2018

Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.

Chemico-biological interactions

Shen Z,Wang Y,Su Z,Kou R,Xie K,Song F

Sun Feb 25 00:00:00 UTC 2018

Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.

Chemico-biological interactions

Shen Z,Wang Y,Su Z,Kou R,Xie K,Song F

Sun Feb 25 00:00:00 UTC 2018

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.

Molecular and cellular biology

Cloer EW,Siesser PF,Cousins EM,Goldfarb D,Mowrey DD,Harrison JS,Weir SJ,Dokholyan NV,Major MB

Thu Nov 15 00:00:00 UTC 2018

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Journal of cellular biochemistry

Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S

Thu Nov 01 00:00:00 UTC 2018

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Journal of cellular biochemistry

Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S

Thu Nov 01 00:00:00 UTC 2018

Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.

Toxicology and applied pharmacology

Yang B,Cheng H,Wang L,Fu J,Zhang G,Guan D,Qi R,Gao X,Zhao R

Sat Sep 15 00:00:00 UTC 2018

Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.

Toxicology and applied pharmacology

Yang B,Cheng H,Wang L,Fu J,Zhang G,Guan D,Qi R,Gao X,Zhao R

Sat Sep 15 00:00:00 UTC 2018

Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.

Toxicology letters

Qiao Y,Xu L,Tao X,Yin L,Qi Y,Xu Y,Han X,Tang Z,Ma X,Liu K,Peng J

Thu Mar 01 00:00:00 UTC 2018

Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.

Toxicology letters

Qiao Y,Xu L,Tao X,Yin L,Qi Y,Xu Y,Han X,Tang Z,Ma X,Liu K,Peng J

Thu Mar 01 00:00:00 UTC 2018

The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.

Environmental toxicology

Lin EY,Bayarsengee U,Wang CC,Chiang YH,Cheng CW

Mon Jan 01 00:00:00 UTC 2018

The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.

Environmental toxicology

Lin EY,Bayarsengee U,Wang CC,Chiang YH,Cheng CW

Mon Jan 01 00:00:00 UTC 2018

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.

Journal of applied toxicology : JAT

Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S

Sat Sep 01 00:00:00 UTC 2018

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.

Journal of applied toxicology : JAT

Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S

Sat Sep 01 00:00:00 UTC 2018

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.

Regulatory toxicology and pharmacology : RTP

Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K

Mon Oct 01 00:00:00 UTC 2018

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.

Regulatory toxicology and pharmacology : RTP

Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K

Mon Oct 01 00:00:00 UTC 2018

Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.

Bioorganic & medicinal chemistry

Li YR,Li GH,Zhou MX,Xiang L,Ren DM,Lou HX,Wang XN,Shen T

Mon Oct 01 00:00:00 UTC 2018

Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.

Bioorganic & medicinal chemistry

Li YR,Li GH,Zhou MX,Xiang L,Ren DM,Lou HX,Wang XN,Shen T

Mon Oct 01 00:00:00 UTC 2018

Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.

Thoracic cancer

Zhang J,Jiao Q,Kong L,Yu J,Fang A,Li M,Yu J

Fri Jun 01 00:00:00 UTC 2018

Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.

Thoracic cancer

Zhang J,Jiao Q,Kong L,Yu J,Fang A,Li M,Yu J

Fri Jun 01 00:00:00 UTC 2018

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.

The Journal of clinical investigation

Hassannia B,Wiernicki B,Ingold I,Qu F,Van Herck S,Tyurina YY,Bayır H,Abhari BA,Angeli JPF,Choi SM,Meul E,Heyninck K,Declerck K,Chirumamilla CS,Lahtela-Kakkonen M,Van Camp G,Krysko DV,Ekert PG,Fulda S,De Geest BG,Conrad M,Kagan VE,Vanden Berghe W,Vandenabeele P,Vanden Berghe T

Wed Aug 01 00:00:00 UTC 2018

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats.

Frontiers in pharmacology

Cai SA,Hou N,Zhao GJ,Liu XW,He YY,Liu HL,Hua YQ,Li LR,Huang Y,Ou CW,Luo CF,Chen MS

Tue Sep 29 00:00:00 UTC 2020

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats.

Frontiers in pharmacology

Cai SA,Hou N,Zhao GJ,Liu XW,He YY,Liu HL,Hua YQ,Li LR,Huang Y,Ou CW,Luo CF,Chen MS

Tue Sep 29 00:00:00 UTC 2020

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.

Frontiers in pharmacology

Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P

Wed Sep 30 00:00:00 UTC 2020

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.

Frontiers in pharmacology

Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P

Wed Sep 30 00:00:00 UTC 2020

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.

Frontiers in pharmacology

Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P

Wed Sep 30 00:00:00 UTC 2020

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.

Frontiers in pharmacology

Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P

Wed Sep 30 00:00:00 UTC 2020

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.

Frontiers in pharmacology

Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P

Wed Sep 30 00:00:00 UTC 2020

The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats.

Environmental toxicology and pharmacology

Hu Y,Yu C,Yao M,Wang L,Liang B,Zhang B,Huang X,Zhang A

Sat Sep 01 00:00:00 UTC 2018

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.

Cell reports

Cai J,Pires KM,Ferhat M,Chaurasia B,Buffolo MA,Smalling R,Sargsyan A,Atkinson DL,Summers SA,Graham TE,Boudina S

Tue Nov 13 00:00:00 UTC 2018

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.

Cell reports

Cai J,Pires KM,Ferhat M,Chaurasia B,Buffolo MA,Smalling R,Sargsyan A,Atkinson DL,Summers SA,Graham TE,Boudina S

Tue Nov 13 00:00:00 UTC 2018

Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2.

Oncology reports

Wu J,Shang AQ,Chen C,Wang WW,Xiong CQ,Guo NZ

Thu Nov 01 00:00:00 UTC 2018

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.

PloS one

Adams O,Janser FA,Dislich B,Berezowska S,Humbert M,Seiler CA,Kroell D,Slotta-Huspenina J,Feith M,Ott K,Tschan MP,Langer R

Tue Dec 11 00:00:00 UTC 2018

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.

PloS one

Adams O,Janser FA,Dislich B,Berezowska S,Humbert M,Seiler CA,Kroell D,Slotta-Huspenina J,Feith M,Ott K,Tschan MP,Langer R

Tue Dec 11 00:00:00 UTC 2018

Nrf2 protects stellate cells from Smad-dependent cell activation.

PloS one

Prestigiacomo V,Suter-Dick L

Mon Jan 14 00:00:00 UTC 2019

Nrf2 protects stellate cells from Smad-dependent cell activation.

PloS one

Prestigiacomo V,Suter-Dick L

Mon Jan 14 00:00:00 UTC 2019

Nrf2 protects stellate cells from Smad-dependent cell activation.

PloS one

Prestigiacomo V,Suter-Dick L

Mon Jan 14 00:00:00 UTC 2019

Nrf2 protects stellate cells from Smad-dependent cell activation.

PloS one

Prestigiacomo V,Suter-Dick L

Mon Jan 14 00:00:00 UTC 2019

Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.

Redox biology

Zhou MX,Li GH,Sun B,Xu YW,Li AL,Li YR,Ren DM,Wang XN,Wen XS,Lou HX,Shen T

Sun Apr 01 00:00:00 UTC 2018

Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.

Redox biology

Zhou MX,Li GH,Sun B,Xu YW,Li AL,Li YR,Ren DM,Wang XN,Wen XS,Lou HX,Shen T

Sun Apr 01 00:00:00 UTC 2018

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.

Scientific reports

Endo H,Owada S,Inagaki Y,Shida Y,Tatemichi M

Wed Jul 04 00:00:00 UTC 2018

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.

Scientific reports

Endo H,Owada S,Inagaki Y,Shida Y,Tatemichi M

Wed Jul 04 00:00:00 UTC 2018

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.

Molecular and cellular biology

Kageyama S,Saito T,Obata M,Koide RH,Ichimura Y,Komatsu M

Sun Apr 01 00:00:00 UTC 2018

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.

Molecular and cellular biology

Kageyama S,Saito T,Obata M,Koide RH,Ichimura Y,Komatsu M

Sun Apr 01 00:00:00 UTC 2018

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.

Redox biology

Zhao L,Tao X,Qi Y,Xu L,Yin L,Peng J

Fri Jun 01 00:00:00 UTC 2018

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.

Redox biology

Zhao L,Tao X,Qi Y,Xu L,Yin L,Peng J

Fri Jun 01 00:00:00 UTC 2018

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

PloS one

Kanamoto M,Tsuchiya Y,Nakao Y,Suzuki T,Motohashi H,Yamamoto M,Kamata H

Mon Apr 01 00:00:00 UTC 2019

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

PloS one

Kanamoto M,Tsuchiya Y,Nakao Y,Suzuki T,Motohashi H,Yamamoto M,Kamata H

Mon Apr 01 00:00:00 UTC 2019

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.

Cancer cell

Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y

Mon Nov 13 00:00:00 UTC 2017

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.

Cancer cell

Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y

Mon Nov 13 00:00:00 UTC 2017

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.

Cancer cell

Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y

Mon Nov 13 00:00:00 UTC 2017

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.

Cancer cell

Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y

Mon Nov 13 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Autophagy

Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G

Tue Oct 03 00:00:00 UTC 2017

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.

Oncogene

Wang Q,Ma J,Lu Y,Zhang S,Huang J,Chen J,Bei JX,Yang K,Wu G,Huang K,Chen J,Xu S

Thu Sep 14 00:00:00 UTC 2017

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.

Oncogene

Wang Q,Ma J,Lu Y,Zhang S,Huang J,Chen J,Bei JX,Yang K,Wu G,Huang K,Chen J,Xu S

Thu Sep 14 00:00:00 UTC 2017

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.

Free radical biology & medicine

Gong W,Li J,Chen Z,Huang J,Chen Q,Cai W,Liu P,Huang H

Mon May 01 00:00:00 UTC 2017

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.

Free radical biology & medicine

Gong W,Li J,Chen Z,Huang J,Chen Q,Cai W,Liu P,Huang H

Mon May 01 00:00:00 UTC 2017

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.

The Journal of cell biology

Hos NJ,Ganesan R,Gutiérrez S,Hos D,Klimek J,Abdullah Z,Krönke M,Robinson N

Mon Dec 04 00:00:00 UTC 2017

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.

The Journal of cell biology

Hos NJ,Ganesan R,Gutiérrez S,Hos D,Klimek J,Abdullah Z,Krönke M,Robinson N

Mon Dec 04 00:00:00 UTC 2017

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.

Molecular cancer research : MCR

Akdemir B,Nakajima Y,Inazawa J,Inoue J

Wed Nov 01 00:00:00 UTC 2017

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.

Molecular cancer research : MCR

Akdemir B,Nakajima Y,Inazawa J,Inoue J

Wed Nov 01 00:00:00 UTC 2017

p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.

American journal of cancer research

Arai A,Chano T,Ikebuchi K,Hama Y,Ochi Y,Tameno H,Shimada T

Thu Oct 01 00:00:00 UTC 2020

p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.

American journal of cancer research

Arai A,Chano T,Ikebuchi K,Hama Y,Ochi Y,Tameno H,Shimada T

Thu Oct 01 00:00:00 UTC 2020

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

The American journal of pathology

Anzovino A,Chiang S,Brown BE,Hawkins CL,Richardson DR,Huang ML

Fri Dec 01 00:00:00 UTC 2017

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

The American journal of pathology

Anzovino A,Chiang S,Brown BE,Hawkins CL,Richardson DR,Huang ML

Fri Dec 01 00:00:00 UTC 2017

A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.

Journal of cell science

O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM

Sun Oct 15 00:00:00 UTC 2017

A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.

Journal of cell science

O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM

Sun Oct 15 00:00:00 UTC 2017

A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.

Journal of cell science

O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM

Sun Oct 15 00:00:00 UTC 2017

A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.

Journal of cell science

O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM

Sun Oct 15 00:00:00 UTC 2017

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells.

Experimental cell research

Huang K,Gao X,Wei W

Fri Dec 01 00:00:00 UTC 2017

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells.

Experimental cell research

Huang K,Gao X,Wei W

Fri Dec 01 00:00:00 UTC 2017

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.

Redox biology

O'Mealey GB,Berry WL,Plafker SM

Sat Apr 01 00:00:00 UTC 2017

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.

Redox biology

O'Mealey GB,Berry WL,Plafker SM

Sat Apr 01 00:00:00 UTC 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 UTC 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 UTC 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 UTC 2017

Exogenous H₂S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.

Cell death & disease

Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W

Thu Aug 10 00:00:00 UTC 2017

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.

Redox biology

Xiao L,Xu X,Zhang F,Wang M,Xu Y,Tang D,Wang J,Qin Y,Liu Y,Tang C,He L,Greka A,Zhou Z,Liu F,Dong Z,Sun L

Sat Apr 01 00:00:00 UTC 2017

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.

Redox biology

Xiao L,Xu X,Zhang F,Wang M,Xu Y,Tang D,Wang J,Qin Y,Liu Y,Tang C,He L,Greka A,Zhou Z,Liu F,Dong Z,Sun L

Sat Apr 01 00:00:00 UTC 2017

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.

Cell death & disease

Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

Thu Jan 05 00:00:00 UTC 2017

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.

Cell death & disease

Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

Thu Jan 05 00:00:00 UTC 2017

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

eLife

Krall EB,Wang B,Munoz DM,Ilic N,Raghavan S,Niederst MJ,Yu K,Ruddy DA,Aguirre AJ,Kim JW,Redig AJ,Gainor JF,Williams JA,Asara JM,Doench JG,Janne PA,Shaw AT,McDonald Iii RE,Engelman JA,Stegmeier F,Schlabach MR,Hahn WC

Wed Feb 01 00:00:00 UTC 2017

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

eLife

Wed Feb 01 00:00:00 UTC 2017

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.

Frontiers in physiology

Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS

Wed Sep 30 00:00:00 UTC 2020

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.

Frontiers in physiology

Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS

Wed Sep 30 00:00:00 UTC 2020

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.

Frontiers in physiology

Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS

Wed Sep 30 00:00:00 UTC 2020

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.

Frontiers in physiology

Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS

Wed Sep 30 00:00:00 UTC 2020

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

Oncotarget

Fabrizio FP,Costantini M,Copetti M,la Torre A,Sparaneo A,Fontana A,Poeta L,Gallucci M,Sentinelli S,Graziano P,Parente P,Pompeo V,De Salvo L,Simone G,Papalia R,Picardo F,Balsamo T,Flammia GP,Trombetta D,Pantalone A,Kok K,Paranita F,Muscarella LA,Fazio VM

Tue Feb 14 00:00:00 UTC 2017

(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yang D,Xiao CX,Su ZH,Huang MW,Qin M,Wu WJ,Jia WW,Zhu YZ,Hu JF,Liu XH

Tue Aug 15 00:00:00 UTC 2017

SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.

Oncotarget

Huang R,Li X,Yu Y,Ma L,Liu S,Zong X,Zheng Q

Tue Nov 07 00:00:00 UTC 2017

SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.

Oncotarget

Huang R,Li X,Yu Y,Ma L,Liu S,Zong X,Zheng Q

Tue Nov 07 00:00:00 UTC 2017

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.

Science signaling

Sergin I,Bhattacharya S,Emanuel R,Esen E,Stokes CJ,Evans TD,Arif B,Curci JA,Razani B

Tue Jan 05 00:00:00 UTC 2016

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.

Science signaling

Sergin I,Bhattacharya S,Emanuel R,Esen E,Stokes CJ,Evans TD,Arif B,Curci JA,Razani B

Tue Jan 05 00:00:00 UTC 2016

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Oncogene

Sakurai T,Isogaya K,Sakai S,Morikawa M,Morishita Y,Ehata S,Miyazono K,Koinuma D

Thu Sep 22 00:00:00 UTC 2016

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Oncogene

Sakurai T,Isogaya K,Sakai S,Morikawa M,Morishita Y,Ehata S,Miyazono K,Koinuma D

Thu Sep 22 00:00:00 UTC 2016

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.

Free radical biology & medicine

Lee DH,Han DH,Nam KT,Park JS,Kim SH,Lee M,Kim G,Min BS,Cha BS,Lee YS,Sung SH,Jeong H,Ji HW,Lee MJ,Lee JS,Lee HY,Chun Y,Kim J,Komatsu M,Lee YH,Bae SH

Sat Oct 01 00:00:00 UTC 2016

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.

Free radical biology & medicine

Lee DH,Han DH,Nam KT,Park JS,Kim SH,Lee M,Kim G,Min BS,Cha BS,Lee YS,Sung SH,Jeong H,Ji HW,Lee MJ,Lee JS,Lee HY,Chun Y,Kim J,Komatsu M,Lee YH,Bae SH

Sat Oct 01 00:00:00 UTC 2016

CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.

Biochemical pharmacology

Gong W,Chen C,Xiong F,Yang Z,Wang Y,Huang J,Liu P,Huang H

Thu Sep 15 00:00:00 UTC 2016

CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.

Biochemical pharmacology

Gong W,Chen C,Xiong F,Yang Z,Wang Y,Huang J,Liu P,Huang H

Thu Sep 15 00:00:00 UTC 2016

Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.

Toxicology

Wang S,Chen Y,Kou R,Wang Y,Zeng T,Xie K,Song F

Wed Aug 10 00:00:00 UTC 2016

Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.

Toxicology

Wang S,Chen Y,Kou R,Wang Y,Zeng T,Xie K,Song F

Wed Aug 10 00:00:00 UTC 2016

Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.

Molecules (Basel, Switzerland)

Zhao L,Xu L,Tao X,Han X,Yin L,Qi Y,Peng J

Thu Jul 21 00:00:00 UTC 2016

Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.

Molecules (Basel, Switzerland)

Zhao L,Xu L,Tao X,Han X,Yin L,Qi Y,Peng J

Thu Jul 21 00:00:00 UTC 2016

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.

Scientific reports

Nlandu-Khodo S,Dissard R,Hasler U,Schäfer M,Pircher H,Jansen-Durr P,Krause KH,Martin PY,de Seigneux S

Wed Dec 07 00:00:00 UTC 2016

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.

Scientific reports

Nlandu-Khodo S,Dissard R,Hasler U,Schäfer M,Pircher H,Jansen-Durr P,Krause KH,Martin PY,de Seigneux S

Wed Dec 07 00:00:00 UTC 2016

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.

Acta neuropathologica communications

Duleh S,Wang X,Komirenko A,Margeta M

Mon Oct 31 00:00:00 UTC 2016

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.

Acta neuropathologica communications

Duleh S,Wang X,Komirenko A,Margeta M

Mon Oct 31 00:00:00 UTC 2016

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.

Free radical research

Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH

Thu Dec 01 00:00:00 UTC 2016

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.

Free radical research

Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH

Thu Dec 01 00:00:00 UTC 2016

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

The Journal of biological chemistry

Mulvaney KM,Matson JP,Siesser PF,Tamir TY,Goldfarb D,Jacobs TM,Cloer EW,Harrison JS,Vaziri C,Cook JG,Major MB

Fri Nov 04 00:00:00 UTC 2016

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

The Journal of biological chemistry

Mulvaney KM,Matson JP,Siesser PF,Tamir TY,Goldfarb D,Jacobs TM,Cloer EW,Harrison JS,Vaziri C,Cook JG,Major MB

Fri Nov 04 00:00:00 UTC 2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nature communications

Saito T,Ichimura Y,Taguchi K,Suzuki T,Mizushima T,Takagi K,Hirose Y,Nagahashi M,Iso T,Fukutomi T,Ohishi M,Endo K,Uemura T,Nishito Y,Okuda S,Obata M,Kouno T,Imamura R,Tada Y,Obata R,Yasuda D,Takahashi K,Fujimura T,Pi J,Lee MS,Ueno T,Ohe T,Mashino T,Wakai T,Kojima H,Okabe T,Nagano T,Motohashi H,Waguri S,Soga T,Yamamoto M,Tanaka K,Komatsu M

Mon Jun 27 00:00:00 UTC 2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nature communications

Mon Jun 27 00:00:00 UTC 2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nature communications

Mon Jun 27 00:00:00 UTC 2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nature communications

Mon Jun 27 00:00:00 UTC 2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nature communications

Mon Jun 27 00:00:00 UTC 2016

Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.

Nutrients

Tao X,Sun X,Xu L,Yin L,Han X,Qi Y,Xu Y,Zhao Y,Wang C,Peng J

Fri Jul 08 00:00:00 UTC 2016

Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.

Nutrients

Tao X,Sun X,Xu L,Yin L,Han X,Qi Y,Xu Y,Zhao Y,Wang C,Peng J

Fri Jul 08 00:00:00 UTC 2016

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.

Journal of hematology & oncology

Tian Y,Wu K,Liu Q,Han N,Zhang L,Chu Q,Chen Y

Tue Sep 06 00:00:00 UTC 2016

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.

Journal of hematology & oncology

Tian Y,Wu K,Liu Q,Han N,Zhang L,Chu Q,Chen Y

Tue Sep 06 00:00:00 UTC 2016

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.

PloS one

Park S,Han S,Choi I,Kim B,Park SP,Joe EH,Suh YH

Wed Aug 02 00:00:00 UTC 2017

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.

PloS one

Park S,Han S,Choi I,Kim B,Park SP,Joe EH,Suh YH

Wed Aug 02 00:00:00 UTC 2017

Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Awuh JA,Haug M,Mildenberger J,Marstad A,Do CP,Louet C,Stenvik J,Steigedal M,Damås JK,Halaas Ø,Flo TH

Tue Aug 04 00:00:00 UTC 2015

Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Awuh JA,Haug M,Mildenberger J,Marstad A,Do CP,Louet C,Stenvik J,Steigedal M,Damås JK,Halaas Ø,Flo TH

Tue Aug 04 00:00:00 UTC 2015

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Brain pathology (Zurich, Switzerland)

Tanji K,Odagiri S,Miki Y,Maruyama A,Nikaido Y,Mimura J,Mori F,Warabi E,Yanagawa T,Ueno S,Itoh K,Wakabayashi K

Tue Sep 01 00:00:00 UTC 2015

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Brain pathology (Zurich, Switzerland)

Tanji K,Odagiri S,Miki Y,Maruyama A,Nikaido Y,Mimura J,Mori F,Warabi E,Yanagawa T,Ueno S,Itoh K,Wakabayashi K

Tue Sep 01 00:00:00 UTC 2015

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.

Journal of cell science

Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M

Tue Dec 01 00:00:00 UTC 2015

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.

Journal of cell science

Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M

Tue Dec 01 00:00:00 UTC 2015

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.

Journal of cell science

Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M

Tue Dec 01 00:00:00 UTC 2015

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.

Journal of cell science

Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M

Tue Dec 01 00:00:00 UTC 2015

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.

Molecular and cellular biology

Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R

Wed Jul 01 00:00:00 UTC 2015

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.

Molecular and cellular biology

Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R

Wed Jul 01 00:00:00 UTC 2015

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.

Molecular and cellular biology

Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R

Wed Jul 01 00:00:00 UTC 2015

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.

Molecular and cellular biology

Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R

Wed Jul 01 00:00:00 UTC 2015

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells.

Molecular and cellular endocrinology

Huang K,Chen C,Hao J,Huang J,Wang S,Liu P,Huang H

Mon Jan 05 00:00:00 UTC 2015

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells.

Molecular and cellular endocrinology

Huang K,Chen C,Hao J,Huang J,Wang S,Liu P,Huang H

Mon Jan 05 00:00:00 UTC 2015

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Sep 25 00:00:00 UTC 2015

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Sep 25 00:00:00 UTC 2015

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Oct 09 00:00:00 UTC 2015

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Oct 09 00:00:00 UTC 2015

PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Oct 23 00:00:00 UTC 2015

PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.

Biochemical and biophysical research communications

Park JS,Kang DH,Lee DH,Bae SH

Fri Oct 23 00:00:00 UTC 2015

p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2.

Biochemical and biophysical research communications

Park JS,Kang DH,Bae SH

Fri Sep 04 00:00:00 UTC 2015

p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2.

Biochemical and biophysical research communications

Park JS,Kang DH,Bae SH

Fri Sep 04 00:00:00 UTC 2015

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Science signaling

Ito A,Shimazu T,Maeda S,Shah AA,Tsunoda T,Iemura S,Natsume T,Suzuki T,Motohashi H,Yamamoto M,Yoshida M

Tue Nov 24 00:00:00 UTC 2015

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Science signaling

Ito A,Shimazu T,Maeda S,Shah AA,Tsunoda T,Iemura S,Natsume T,Suzuki T,Motohashi H,Yamamoto M,Yoshida M

Tue Nov 24 00:00:00 UTC 2015

Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.

PloS one

Probst BL,McCauley L,Trevino I,Wigley WC,Ferguson DA

Wed May 11 00:00:00 UTC 2016

Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.

PloS one

Probst BL,McCauley L,Trevino I,Wigley WC,Ferguson DA

Wed May 11 00:00:00 UTC 2016

Potent effects of dioscin against obesity in mice.

Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 UTC 2015

Potent effects of dioscin against obesity in mice.

Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 UTC 2015

Potent effects of dioscin against liver fibrosis.

Scientific reports

Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J

Wed Apr 08 00:00:00 UTC 2015

Potent effects of dioscin against liver fibrosis.

Scientific reports

Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J

Wed Apr 08 00:00:00 UTC 2015

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

Hepatology (Baltimore, Md.)

Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A

Wed Jan 01 00:00:00 UTC 2014

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

Hepatology (Baltimore, Md.)

Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A

Wed Jan 01 00:00:00 UTC 2014

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

Hepatology (Baltimore, Md.)

Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A

Wed Jan 01 00:00:00 UTC 2014

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

Hepatology (Baltimore, Md.)

Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A

Wed Jan 01 00:00:00 UTC 2014

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Cancer research

Hast BE,Cloer EW,Goldfarb D,Li H,Siesser PF,Yan F,Walter V,Zheng N,Hayes DN,Major MB

Sat Feb 01 00:00:00 UTC 2014

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Cancer research

Hast BE,Cloer EW,Goldfarb D,Li H,Siesser PF,Yan F,Walter V,Zheng N,Hayes DN,Major MB

Sat Feb 01 00:00:00 UTC 2014

The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.

Molecular cancer research : MCR

Yamamoto S,Inoue J,Kawano T,Kozaki K,Omura K,Inazawa J

Wed Jan 01 00:00:00 UTC 2014

The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.

Molecular cancer research : MCR

Yamamoto S,Inoue J,Kawano T,Kozaki K,Omura K,Inazawa J

Wed Jan 01 00:00:00 UTC 2014

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.

Journal of proteome research

Goldfarb D,Hast BE,Wang W,Major MB

Fri Dec 05 00:00:00 UTC 2014

Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.

Journal of proteome research

Goldfarb D,Hast BE,Wang W,Major MB

Fri Dec 05 00:00:00 UTC 2014

Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts.

Toxicology and applied pharmacology

Nordgren KK,Wallace KB

Wed Jan 01 00:00:00 UTC 2014

Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts.

Toxicology and applied pharmacology

Nordgren KK,Wallace KB

Wed Jan 01 00:00:00 UTC 2014

Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.

American journal of translational research

Huo L,Li CW,Huang TH,Lam YC,Xia W,Tu C,Chang WC,Hsu JL,Lee DF,Nie L,Yamaguchi H,Wang Y,Lang J,Li LY,Chen CH,Mishra L,Hung MC

Wed Jan 28 00:00:00 UTC 2015

Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.

American journal of translational research

Huo L,Li CW,Huang TH,Lam YC,Xia W,Tu C,Chang WC,Hsu JL,Lee DF,Nie L,Yamaguchi H,Wang Y,Lang J,Li LY,Chen CH,Mishra L,Hung MC

Wed Jan 28 00:00:00 UTC 2015

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.

FEBS letters

Ishimura R,Tanaka K,Komatsu M

Mon Mar 03 00:00:00 UTC 2014

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.

FEBS letters

Ishimura R,Tanaka K,Komatsu M

Mon Mar 03 00:00:00 UTC 2014

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Acta neuropathologica communications

Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Sat May 03 00:00:00 UTC 2014

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Acta neuropathologica communications

Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Sat May 03 00:00:00 UTC 2014

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Acta neuropathologica communications

Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Sat May 03 00:00:00 UTC 2014

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Acta neuropathologica communications

Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Sat May 03 00:00:00 UTC 2014

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.

The Journal of biological chemistry

Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M

Fri Sep 05 00:00:00 UTC 2014

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.

The Journal of biological chemistry

Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M

Fri Sep 05 00:00:00 UTC 2014

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.

The Journal of biological chemistry

Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M

Fri Sep 05 00:00:00 UTC 2014

Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.

The Journal of biological chemistry

Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M

Fri Sep 05 00:00:00 UTC 2014

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

Nature communications

Jo C,Gundemir S,Pritchard S,Jin YN,Rahman I,Johnson GV

Tue Mar 25 00:00:00 UTC 2014

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

Nature communications

Jo C,Gundemir S,Pritchard S,Jin YN,Rahman I,Johnson GV

Tue Mar 25 00:00:00 UTC 2014

SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.

PloS one

Darvekar SR,Elvenes J,Brenne HB,Johansen T,Sjøttem E

Tue Sep 02 00:00:00 UTC 2014

SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.

PloS one

Darvekar SR,Elvenes J,Brenne HB,Johansen T,Sjøttem E

Tue Sep 02 00:00:00 UTC 2014

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Molecular cell

Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M

Thu Sep 12 00:00:00 UTC 2013

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Molecular cell

Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M

Thu Sep 12 00:00:00 UTC 2013

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Molecular cell

Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M

Thu Sep 12 00:00:00 UTC 2013

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Molecular cell

Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M

Thu Sep 12 00:00:00 UTC 2013

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Molecular cell

Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M

Thu Sep 12 00:00:00 UTC 2013

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Cancer research

Hast BE,Goldfarb D,Mulvaney KM,Hast MA,Siesser PF,Yan F,Hayes DN,Major MB

Mon Apr 01 00:00:00 UTC 2013

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Cancer research

Hast BE,Goldfarb D,Mulvaney KM,Hast MA,Siesser PF,Yan F,Hayes DN,Major MB

Mon Apr 01 00:00:00 UTC 2013

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Molecular biology of the cell

Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F

Sat Jun 01 00:00:00 UTC 2013

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Molecular biology of the cell

Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F

Sat Jun 01 00:00:00 UTC 2013

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Molecular biology of the cell

Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F

Sat Jun 01 00:00:00 UTC 2013

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Molecular biology of the cell

Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F

Sat Jun 01 00:00:00 UTC 2013

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Journal of neuropathology and experimental neurology

Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Tue Jan 01 00:00:00 UTC 2013

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Journal of neuropathology and experimental neurology

Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Tue Jan 01 00:00:00 UTC 2013

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Journal of neuropathology and experimental neurology

Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Tue Jan 01 00:00:00 UTC 2013

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Journal of neuropathology and experimental neurology

Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K

Tue Jan 01 00:00:00 UTC 2013

Association of p62/SQSTM1 excess and oral carcinogenesis.

PloS one

Inui T,Chano T,Takikita-Suzuki M,Nishikawa M,Yamamoto G,Okabe H

Fri Jul 18 00:00:00 UTC 2014

Association of p62/SQSTM1 excess and oral carcinogenesis.

PloS one

Inui T,Chano T,Takikita-Suzuki M,Nishikawa M,Yamamoto G,Okabe H

Fri Jul 18 00:00:00 UTC 2014

Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.

PloS one

Endo H,Niioka M,Kobayashi N,Tanaka M,Watanabe T

Mon Dec 23 00:00:00 UTC 2013

Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.

PloS one

Endo H,Niioka M,Kobayashi N,Tanaka M,Watanabe T

Mon Dec 23 00:00:00 UTC 2013

Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.

International journal of cell biology

Kwok SC

Tue Mar 12 00:00:00 UTC 2013

Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.

International journal of cell biology

Kwok SC

Tue Mar 12 00:00:00 UTC 2013

Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.

PloS one

Jin YN,Yu YV,Gundemir S,Jo C,Cui M,Tieu K,Johnson GV

Tue Aug 27 00:00:00 UTC 2013

Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.

PloS one

Jin YN,Yu YV,Gundemir S,Jo C,Cui M,Tieu K,Johnson GV

Tue Aug 27 00:00:00 UTC 2013

Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.

Applied immunohistochemistry & molecular morphology : AIMM

Chang LC,Fan CW,Tseng WK,Chen JR,Chein HP,Hwang CC,Hua CC

Sun Dec 01 00:00:00 UTC 2013

Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.

Applied immunohistochemistry & molecular morphology : AIMM

Chang LC,Fan CW,Tseng WK,Chen JR,Chein HP,Hwang CC,Hua CC

Sun Dec 01 00:00:00 UTC 2013

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.

Cancer research

Leinonen HM,Ruotsalainen AK,Määttä AM,Laitinen HM,Kuosmanen SM,Kansanen E,Pikkarainen JT,Lappalainen JP,Samaranayake H,Lesch HP,Kaikkonen MU,Ylä-Herttuala S,Levonen AL

Sat Dec 01 00:00:00 UTC 2012

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.

Cancer research

Leinonen HM,Ruotsalainen AK,Määttä AM,Laitinen HM,Kuosmanen SM,Kansanen E,Pikkarainen JT,Lappalainen JP,Samaranayake H,Lesch HP,Kaikkonen MU,Ylä-Herttuala S,Levonen AL

Sat Dec 01 00:00:00 UTC 2012

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.

EMBO reports

Kwon J,Han E,Bui CB,Shin W,Lee J,Lee S,Choi YB,Lee AH,Lee KH,Park C,Obin MS,Park SK,Seo YJ,Oh GT,Lee HW,Shin J

Wed Feb 01 00:00:00 UTC 2012

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.

EMBO reports

Kwon J,Han E,Bui CB,Shin W,Lee J,Lee S,Choi YB,Lee AH,Lee KH,Park C,Obin MS,Park SK,Seo YJ,Oh GT,Lee HW,Shin J

Wed Feb 01 00:00:00 UTC 2012

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.

EMBO reports

Kwon J,Han E,Bui CB,Shin W,Lee J,Lee S,Choi YB,Lee AH,Lee KH,Park C,Obin MS,Park SK,Seo YJ,Oh GT,Lee HW,Shin J

Wed Feb 01 00:00:00 UTC 2012

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.

Free radical biology & medicine

Muthusamy VR,Kannan S,Sadhaasivam K,Gounder SS,Davidson CJ,Boeheme C,Hoidal JR,Wang L,Rajasekaran NS

Sun Jan 15 00:00:00 UTC 2012

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.

Free radical biology & medicine

Muthusamy VR,Kannan S,Sadhaasivam K,Gounder SS,Davidson CJ,Boeheme C,Hoidal JR,Wang L,Rajasekaran NS

Sun Jan 15 00:00:00 UTC 2012

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.

Breast cancer research and treatment

Agyeman AS,Chaerkady R,Shaw PG,Davidson NE,Visvanathan K,Pandey A,Kensler TW

Wed Feb 01 00:00:00 UTC 2012

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.

Breast cancer research and treatment

Agyeman AS,Chaerkady R,Shaw PG,Davidson NE,Visvanathan K,Pandey A,Kensler TW

Wed Feb 01 00:00:00 UTC 2012

Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.

Biochemical and biophysical research communications

Thanan R,Ma N,Iijima K,Abe Y,Koike T,Shimosegawa T,Pinlaor S,Hiraku Y,Oikawa S,Murata M,Kawanishi S

Fri May 04 00:00:00 UTC 2012

Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.

Biochemical and biophysical research communications

Thanan R,Ma N,Iijima K,Abe Y,Koike T,Shimosegawa T,Pinlaor S,Hiraku Y,Oikawa S,Murata M,Kawanishi S

Fri May 04 00:00:00 UTC 2012

Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.

Biochimica et biophysica acta

Miller CJ,Gounder SS,Kannan S,Goutam K,Muthusamy VR,Firpo MA,Symons JD,Paine R,Hoidal JR,Rajasekaran NS

Fri Jun 01 00:00:00 UTC 2012

Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.

Biochimica et biophysica acta

Miller CJ,Gounder SS,Kannan S,Goutam K,Muthusamy VR,Firpo MA,Symons JD,Paine R,Hoidal JR,Rajasekaran NS

Fri Jun 01 00:00:00 UTC 2012

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.

The Journal of biological chemistry

Camp ND,James RG,Dawson DW,Yan F,Davison JM,Houck SA,Tang X,Zheng N,Major MB,Moon RT

Fri Feb 24 00:00:00 UTC 2012

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.

The Journal of biological chemistry

Camp ND,James RG,Dawson DW,Yan F,Davison JM,Houck SA,Tang X,Zheng N,Major MB,Moon RT

Fri Feb 24 00:00:00 UTC 2012

[Keap1 expression for predicting the chemoresistance and prognosis of advanced non-small cell lung cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer

Cao B,Zhu X,Chen S,Xiao Y,Liang L

Mon Oct 01 00:00:00 UTC 2012

Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma.

PloS one

Matulis SM,Morales AA,Yehiayan L,Lee KP,Cai Y,Boise LH

Thu Jun 27 00:00:00 UTC 2013

Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma.

PloS one

Matulis SM,Morales AA,Yehiayan L,Lee KP,Cai Y,Boise LH

Thu Jun 27 00:00:00 UTC 2013

Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

PloS one

Lockwood WW,Wilson IM,Coe BP,Chari R,Pikor LA,Thu KL,Solis LM,Nunez MI,Behrens C,Yee J,English J,Murray N,Tsao MS,Minna JD,Gazdar AF,Wistuba II,MacAulay CE,Lam S,Lam WL

Mon Dec 17 00:00:00 UTC 2012

Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

PloS one

Lockwood WW,Wilson IM,Coe BP,Chari R,Pikor LA,Thu KL,Solis LM,Nunez MI,Behrens C,Yee J,English J,Murray N,Tsao MS,Minna JD,Gazdar AF,Wistuba II,MacAulay CE,Lam S,Lam WL

Mon Dec 17 00:00:00 UTC 2012

Autophagy-deficient mice develop multiple liver tumors.

Genes & development

Takamura A,Komatsu M,Hara T,Sakamoto A,Kishi C,Waguri S,Eishi Y,Hino O,Tanaka K,Mizushima N

Fri Apr 15 00:00:00 UTC 2011

Autophagy-deficient mice develop multiple liver tumors.

Genes & development

Takamura A,Komatsu M,Hara T,Sakamoto A,Kishi C,Waguri S,Eishi Y,Hino O,Tanaka K,Mizushima N

Fri Apr 15 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

The Journal of cell biology

Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M

Mon Apr 18 00:00:00 UTC 2011

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

Antioxidants & redox signaling

Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ

Tue Mar 15 00:00:00 UTC 2011

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

Antioxidants & redox signaling

Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ

Tue Mar 15 00:00:00 UTC 2011

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

Antioxidants & redox signaling

Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ

Tue Mar 15 00:00:00 UTC 2011

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

Antioxidants & redox signaling

Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ

Tue Mar 15 00:00:00 UTC 2011

Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.

Archives of toxicology

Sumi D,Sasaki T,Miyataka H,Himeno S

Thu Dec 01 00:00:00 UTC 2011

Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.

Archives of toxicology

Sumi D,Sasaki T,Miyataka H,Himeno S

Thu Dec 01 00:00:00 UTC 2011

Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.

Biochemical and biophysical research communications

Bui CB,Shin J

Fri Aug 26 00:00:00 UTC 2011

Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.

Biochemical and biophysical research communications

Bui CB,Shin J

Fri Aug 26 00:00:00 UTC 2011

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Nature cell biology

Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M

Mon Mar 01 00:00:00 UTC 2010

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Nature cell biology

Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M

Mon Mar 01 00:00:00 UTC 2010

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Nature cell biology

Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M

Mon Mar 01 00:00:00 UTC 2010

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Nature cell biology

Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M

Mon Mar 01 00:00:00 UTC 2010

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.

Clinical cancer research : an official journal of the American Association for Cancer Research

Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II

Thu Jul 15 00:00:00 UTC 2010

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.

Clinical cancer research : an official journal of the American Association for Cancer Research

Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II

Thu Jul 15 00:00:00 UTC 2010

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.

Clinical cancer research : an official journal of the American Association for Cancer Research

Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II

Thu Jul 15 00:00:00 UTC 2010

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.

Clinical cancer research : an official journal of the American Association for Cancer Research

Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II

Thu Jul 15 00:00:00 UTC 2010

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.

The Journal of biological chemistry

Kang HJ,Hong YB,Kim HJ,Bae I

Fri Jul 09 00:00:00 UTC 2010

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.

The Journal of biological chemistry

Kang HJ,Hong YB,Kim HJ,Bae I

Fri Jul 09 00:00:00 UTC 2010

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.

The Journal of biological chemistry

Kang HJ,Hong YB,Kim HJ,Bae I

Fri Jul 09 00:00:00 UTC 2010

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

Molecular cell

Lee DF,Kuo HP,Liu M,Chou CK,Xia W,Du Y,Shen J,Chen CT,Huo L,Hsu MC,Li CW,Ding Q,Liao TL,Lai CC,Lin AC,Chang YH,Tsai SF,Li LY,Hung MC

Fri Oct 09 00:00:00 UTC 2009

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

Molecular cell

Lee DF,Kuo HP,Liu M,Chou CK,Xia W,Du Y,Shen J,Chen CT,Huo L,Hsu MC,Li CW,Ding Q,Liao TL,Lai CC,Lin AC,Chang YH,Tsai SF,Li LY,Hung MC

Fri Oct 09 00:00:00 UTC 2009

Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.

The Journal of biological chemistry

Morales AA,Gutman D,Cejas PJ,Lee KP,Boise LH

Fri May 08 00:00:00 UTC 2009

Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.

The Journal of biological chemistry

Morales AA,Gutman D,Cejas PJ,Lee KP,Boise LH

Fri May 08 00:00:00 UTC 2009

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Circulation research

Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA

Fri Sep 28 00:00:00 UTC 2007

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Circulation research

Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA

Fri Sep 28 00:00:00 UTC 2007

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Circulation research

Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA

Fri Sep 28 00:00:00 UTC 2007

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Circulation research

Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA

Fri Sep 28 00:00:00 UTC 2007

Bioinformatics

Protein Aliases: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; NRF2 cytosolic inhibitor; ring canal protein

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Gene Aliases: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132

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UniProt ID: (Human) Q14145, (Mouse) Q9Z2X8

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Entrez Gene ID: (Human) 9817, (Mouse) 50868, (Rat) 117519

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Function(s)

ubiquitin-protein transferase activity protein binding transcription factor binding

Process(es)

in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated proteasomal ubiquitin-independent protein catabolic process negative regulation of gene expression protein ubiquitination positive regulation of cellular protein metabolic process cytoplasmic sequestering of transcription factor regulation of epidermal cell differentiation protein oligomerization cellular response to interleukin-4 selenium compound metabolic process malate metabolic process flavonoid metabolic process response to metal ion alkanesulfonate metabolic process response to immobilization stress cellular response to organic cyclic compound response to thyroid hormone positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of sequence-specific DNA binding transcription factor activity

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KEAP1 Polyclonal Antibody

KEAP1 Antibody (10503-2-AP) in IHC (P)

Product Details

10503-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

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Concentration

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Contains

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Bioinformatics

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