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KHDRBS3 Polyclonal Antibody

KHDRBS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KHDRBS3 Antibody (13563-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas using 13563-1-AP (KHDRBS3 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

13563-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:12,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KHDRBS3 Fusion Protein Ag4438 (1-346 aa encoded by BC032606)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against a full-length human KHDRBS3 protein. The observed molecular weight of KHDRBS is about 55 kDa.

Immunogen sequence: MEEKYLPEL MAEKDSLDPS FTHALRLVNQ EIEKFQKGEG KDEEKYIDVV INKNMKLGQK VLIPVKQFPK FNFVGKLLGP RGNSLKRLQE ETLTKMSILG KGSMRDKAKE EELRKSGEAK YFHLNDDLHV LIEVFAPPAE AYARMGHALE EIKKFLIPDY NDEIRQAQLQ ELTYLNGGSE NADVPVVRGK PTLRTRGVPA PAITRGRGGV TARPVGVVVP RGTPTPRGVL STRGPVSRGR GLLTPRARGV PPTGYRPPPP PPTQETYGEY DYDDGYGTAY DEQSYDSYDN SYSTPAQSGA DYYDYGHGLS EETYDSYGQE EWTNSRHKAP SARTAKGVYR DQPYGRY (1-346 aa encoded by BC032606)

Target Information

As a RNA-binding protein, KHDRBS3 plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. KHDRBS3 may play a role as a negative regulator of cell growth. It inhibits cell proliferation and involved in splice site selection of vascular endothelial growth factor. It induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. It also involved in post-transcriptional regulation of HIV-1 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

KHDRBS3 regulates the permeability of blood-tumor barrier via cDENND4C/miR-577 axis.

Cell death & disease

Wu P,Gao Y,Shen S,Xue Y,Liu X,Ruan X,Shao L,Liu Y,Wang P

Thu Jul 11 00:00:00 UTC 2019

The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain.

PLoS genetics

Ehrmann I,Dalgliesh C,Liu Y,Danilenko M,Crosier M,Overman L,Arthur HM,Lindsay S,Clowry GJ,Venables JP,Fort P,Elliott DJ

Mon Apr 01 00:00:00 UTC 2013

The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain.

PLoS genetics

Ehrmann I,Dalgliesh C,Liu Y,Danilenko M,Crosier M,Overman L,Arthur HM,Lindsay S,Clowry GJ,Venables JP,Fort P,Elliott DJ

Mon Apr 01 00:00:00 UTC 2013

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 UTC 2012

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: etoile; etoile, Sam68-like protein SLM-2; KH domain containing, RNA binding, signal transduction associated 3; KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein Etoile; RNA-binding protein T-Star; rSLM-2; Sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein; Sam68-like phosphotyrosine protein, T-STAR; SLM-2

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Gene Aliases: Etle; etoile; KHDRBS3; SALP; SLM-2; SLM2; T-STAR; TSTAR

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UniProt ID: (Human) O75525, (Rat) Q9JLP1, (Mouse) Q9R226

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Entrez Gene ID: (Human) 10656, (Rat) 64015, (Mouse) 13992

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Function(s)

RNA binding protein binding SH3 domain binding poly(A) RNA binding single-stranded RNA binding nucleic acid binding

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated mRNA processing positive regulation of RNA splicing spermatogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KHDRBS3 Polyclonal Antibody

KHDRBS3 Antibody (13563-1-AP) in IHC (P)

Product Details

13563-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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