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Abnova
KIAA0141 Polyclonal Antibody, MaxPab™
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Product Details
H00009812-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIAA0141 (NP_055588, 1 a.a. approximately 515 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MWRLPGLLGR ALPRTLGPSL WRVTPKSTSP DGPQTTSSTL LVPVPNLDRS GPHGPGTSGG PRSHGWKDAF QWMSSRVSPN TLWDAISWGT LAVLALQLAR QIHFQASLPA GPQRVEHCSW HSPLDRFFSS PLWHPCSSLR QHILPSPDGP APRHTGLREP RLGQEEASAQ PRNFSHNSLR GARPQDPSEE GPGDFGFLHA SSSIESEAKP AQPQPTGEKE QDKSKTLSLE EAVTSIQQLF QLSVSITFNF LGTENMKSGD HTAAFSYFQK AAARGYSKAQ YNAGLCHEHG RGTPRDISKA VLYYQLAASQ GHSLAQYRYA RCLLRDPASS WNPERQRAVS LLKQAADSGL REAQAFLGVL FTKEPYLDEQ RAVKYLWLAA NNGDSQSRYH LGICYEKGLG VQRNLGEALR CYQQSAALGN EAAQERLRAL FSMGAAAPGP SDLTVTGLKS FSSPSLCSLN TLLAGTSRLP HASSTGNLGL LCRSGHLGAS LEASSRAIPP HPYPLERSVV RLGFG
Target Information
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; Death ligand signal enhancer; DELE1(L)
Gene Aliases: DELE; DELE1; KIAA0141
UniProt ID: (Human) Q14154
Entrez Gene ID: (Human) 9812
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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