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Abnova
KIAA0157 Polyclonal Antibody, MaxPab™
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Product Details
H00023172-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIAA0157 (NP_115558.2, 1 a.a. approximately 311 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSYREQVLHK QLTRILGVPD LVFLLFSFIS TANNSTHALE YVLFRPNRRY NQRISLAIPN LGNTSQQEYK VSSVPNTSQS YAKVIKEHGT DFFDKDGVMK DIRAIYQVYN ALQEKVQAVC ADVEKSERVV ESCQAEVNKL RRQITQRKNE KEQERRLQQA VLSRQMPSES LDPAFSPRMP SSGFAAEGRS TLGDAEASDP PPPYSDFHPN NQESTLSHSR MERSVFMPRP QAVGSSNYAS TSAGLKYPGS GADLPPPQRA AGDSGEDSDD SDYENLIDPT EPSNSEYSHS KDSRPMAHPD EDPRNTQTSQ I
Target Information
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abraxas brother; abraxas brother 1; Abraxas brother protein 1; BRISC complex subunit Abraxas 2; Em:AC068896.4; family with sequence similarity 175, member B; Protein FAM175B
Gene Aliases: ABRAXAS2; ABRO1; FAM175B; KIAA0157
UniProt ID: (Human) Q15018
Entrez Gene ID: (Human) 23172
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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