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Immunogen sequence: ARKQCSEGRT YSNAVISPNL ETTRIMRVSH TFPVVDCTAA CCDLSSCDLA WWFEGRCYLV SCPHKENCEP KKMGPIRSYL TFVLRPVQRP AQLLDYGDMM LNRGSPSGIW GDSPEDIRKD LTFLGKDWGL EEMSEYSDDY RELEKDLLQP SGKQEPRGSA EYTDWGLLPG SEGAFNSSVG DSPAVPAETQ QDPELHYLNE SASTPAPKLP ERSVLLPLPT TPSSGEVLEK EKASQLQEQS SNSSGKEVLM PSHSLPPASL ELSSVTVEKS PVLTVTPGST; Positive Samples: U-87MG, Mouse brain; Cellular Location: Cell membrane, Early endosome membrane, Single-pass type I membrane protein
This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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Protein Aliases: dyslexia susceptibility 2; Dyslexia-associated protein KIAA0319; Dyslexia-associated protein KIAA0319 homolog; mKIAA0319; neuronal migration
Gene Aliases: 4930451E12Rik; DYLX2; DYX2; KIAA0319; NMIG
UniProt ID: (Mouse) Q5SZV5, (Human) Q5VV43
Entrez Gene ID: (Mouse) 210108, (Human) 9856
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