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Immunogen sequence: KEALSNKASK KICVKNVPCD SEHMRPSKLA VQVESCGKSN EKHSSGVQTS KESLNGLTSH GKNLKIHHSQ ESKTYNILRN VKEKVGGKQP DKIWIDKTKL DKLTNISNEA QFSQMPPQVK DQKKLYLNRV GFKCTERE
Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 49%.
Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Retroelement silencing factor 1; uncharacterized protein C12orf35
Gene Aliases: C12orf35; KIAA1551; RESF1; UTA2-1
UniProt ID: (Human) Q9HCM1
Entrez Gene ID: (Human) 55196
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