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Invitrogen
KIF14 Polyclonal Antibody
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Product Details
PA5-58231
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KIF14. Recombinant protein control fragment (Product #RP-94981).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2643084
Product Specific Information
Immunogen sequence: KESRTNVRIV NNAKNSFVAS SVPLDEDPQV IEMMADKKYK ETFSAPSRAN ENVALKYSSN RPPIASLSQT EVV
Highest antigen sequence identity to the following orthologs: Mouse - 30%, Rat - 34%.
Target Information
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kinesin-like protein KIF14
Gene Aliases: KIAA0042; KIF14; MKS12
UniProt ID: (Human) Q15058
Entrez Gene ID: (Human) 9928
regulation of cell growth
microtubule-based movement
microtubule depolymerization
mitotic metaphase plate congression
positive regulation of cell proliferation
regulation of G2/M transition of mitotic cell cycle
cerebellar granular layer structural organization
cerebellar Purkinje cell layer structural organization
cerebellar cortex development
hippocampus development
olfactory bulb development
cell proliferation in forebrain
cerebral cortex development
regulation of cell adhesion
regulation of cell migration
cytoskeleton-dependent intracellular transport
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of myelination
activation of protein kinase activity
positive regulation of cytokinesis
regulation of Rap protein signal transduction
negative regulation of integrin activation
substrate adhesion-dependent cell spreading
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
establishment of protein localization
cell division
response to docetaxel trihydrate
mitotic cell cycle process
regulation of cell maturation
regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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