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Invitrogen
KIF3A Polyclonal Antibody
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KIF3A Antibody (PA5-79555) in WB
Western blot analysis of KIF3A using KIF3A Polyclonal Antibody (Product # PA5-79555). Electrophoresis was performed on a 10% SDS-PAGE gel at 80V (Stacking gel)/120V (Resolving gel) for 2 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: human Jurkat whole cell lysates. Lane 2: human A549 whole cell lysates. Lane 3: human SH-SY5Y whole cell lysates. Lane 4: rat brain tissue lysates. Lane 5: rat C6 whole cell lysates. Lane 6: mouse brain tissue lysates. Lane 7: mouse Neuro-2a whole cell ly... View More
Product Details
PA5-79555
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human KIF3A recombinant protein (Position: D485-Q699).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746670
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Jurkat whole cell, human A549 whole cell, human SH-SY5Y whole cell, rat brain tissue, rat C6 whole cell, mouse brain tissue, mouse Neuro-2a whole cell.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin family protein 3A; kinesin-II subunit; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A; N-4 kinesin
Gene Aliases: FLA10; KIF3; KIF3A; Kifl; KLP-20; Kns3
UniProt ID: (Human) Q9Y496, (Mouse) P28741
Entrez Gene ID: (Human) 11127, (Mouse) 16568, (Rat) 84392
in utero embryonic development
kidney development
heart looping
microtubule-based movement
smoothened signaling pathway
determination of left/right symmetry
heart development
epidermis development
anterior/posterior pattern specification
dorsal/ventral pattern formation
dentate gyrus development
dorsal/ventral neural tube patterning
neural tube development
cell projection organization
nonmotile primary cilium assembly
epidermal stem cell homeostasis
cilium assembly
positive regulation of receptor-mediated endocytosis
positive regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
cilium morphogenesis
neural precursor cell proliferation
motile primary cilium assembly
metabolic process
neurogenesis
retrograde vesicle-mediated transport, Golgi to ER
organelle organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
plus-end-directed vesicle transport along microtubule
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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