Proteintech

KIF5B Polyclonal Antibody

KIF5B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KIF5B Antibody (21632-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 21632-1-AP (KIF5B antibody) at dilution of 1:100 (under 40x lens).

KIF5B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21632-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KIF5B Fusion Protein Ag16250 (662-782 aa encoded by BC126279)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ DL (662-782 aa encoded by BC126279)

Target Information

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.

Bioengineering & translational medicine

Zhu Z,Li X,Wang X,Zuo X,Ma Y,Gao X,Liang Z,Zhang Z,Song Z,Ding T,Ju C,Li P,Li K,Zhang J,Quan H,Wang Z,Hu X

Mon May 01 00:00:00 UTC 2023

Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules.

Journal of virology

Lou JX,Liu YY,Bai JS,Cheng Y,Zhang J,Liu CC,Zhou B

Tue Jan 31 00:00:00 UTC 2023

Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules.

Journal of virology

Lou JX,Liu YY,Bai JS,Cheng Y,Zhang J,Liu CC,Zhou B

Tue Jan 31 00:00:00 UTC 2023

Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules.

Journal of virology

Lou JX,Liu YY,Bai JS,Cheng Y,Zhang J,Liu CC,Zhou B

Tue Jan 31 00:00:00 UTC 2023

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA_A receptor transport in a murine model.

Experimental & molecular medicine

Liu J,Ke P,Guo H,Gu J,Liu Y,Tian X,Wang X,Xiao F

Thu Jun 01 00:00:00 UTC 2023

Mast cell granule motility and exocytosis is driven by dynamic microtubule formation and kinesin-1 motor function.

PloS one

Ibanga J,Zhang EL,Eitzen G,Guo Y

Tue May 03 00:00:00 UTC 2022

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Cancers

Bellio C,Emperador M,Castellano P,Gris-Oliver A,Canals F,Sánchez-Pla A,Zamora E,Arribas J,Saura C,Serra V,Tabernero J,Littlefield BA,Villanueva J

Mon May 23 00:00:00 UTC 2022

Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.

eLife

Wells KM,He K,Pandey A,Cabello A,Zhang D,Yang J,Gomez G,Liu Y,Chang H,Li X,Zhang H,Feng X,da Costa LF,Metz R,Johnson CD,Martin CL,Skrobarczyk J,Berghman LR,Patrick KL,Leibowitz J,Ficht A,Sze SH,Song J,Qian X,Qin QM,Ficht TA,de Figueiredo P

Thu May 19 00:00:00 UTC 2022

Decreased mitochondrial function in UVA-irradiated dermal fibroblasts causes the insufficient formation of type I collagen and fibrillin-1 fibers.

Journal of dermatological science

Katsuyama Y,Yamawaki Y,Sato Y,Muraoka S,Yoshida M,Okano Y,Masaki H

Sat Oct 01 00:00:00 UTC 2022

Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.

Journal of hazardous materials

Kang Y,Yin S,Liu J,Jiang Y,Huang Z,Chen L,Shao L

Tue Feb 15 00:00:00 UTC 2022

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.

EMBO reports

Wang F,Chen X,Cheng H,Song L,Liu J,Caplan S,Zhu L,Wu JY

Mon Jul 05 00:00:00 UTC 2021

Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.

Alzheimer's research & therapy

Chen XQ,Das U,Park G,Mobley WC

Wed Mar 10 00:00:00 UTC 2021

Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.

Virulence

Hou W,Kang W,Li Y,Shan Y,Wang S,Liu F

Wed Dec 01 00:00:00 UTC 2021

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.

Aging

Zhou F,Xiong X,Li S,Liang J,Zhang X,Tian M,Li X,Gao M,Tang L,Li Y

Wed Jun 24 00:00:00 UTC 2020

Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.

Folia neuropathologica

Olczak M,Poniatowski Ł,Kwiatkowska M,Samojłowicz D,Tarka S,Wierzba-Bobrowicz T

Wed Aug 28 00:00:00 UTC 2019

Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.

Neurobiology of disease

Wang Q,Tian J,Chen H,Du H,Guo L

Mon Jul 01 00:00:00 UTC 2019

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.

Cell reports

Franchini DM,Lanvin O,Tosolini M,Patras de Campaigno E,Cammas A,Péricart S,Scarlata CM,Lebras M,Rossi C,Ligat L,Pont F,Arimondo PB,Laurent C,Ayyoub M,Despas F,Lapeyre-Mestre M,Millevoi S,Fournié JJ

Wed Jan 02 00:00:00 UTC 2019

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.

Cell reports

Franchini DM,Lanvin O,Tosolini M,Patras de Campaigno E,Cammas A,Péricart S,Scarlata CM,Lebras M,Rossi C,Ligat L,Pont F,Arimondo PB,Laurent C,Ayyoub M,Despas F,Lapeyre-Mestre M,Millevoi S,Fournié JJ

Wed Jan 02 00:00:00 UTC 2019

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.