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Invitrogen
KIR2DL4 Polyclonal Antibody
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KIR2DL4 Antibody (PA5-88793) in WB
Western blot analysis of KIR2DL4 in 293F-CD158D-C cells. Samples were incubated with KIR2DL4 Polyclonal antibody (Product # PA5-88793) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-88793
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human KIR2DL4 (NP_0022465)
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805135
Product Specific Information
Immunogen sequence: WAHVGGQDKP FCSAWPSAVV PQGGHVTLRC HYRRGFNIFT LYKKDGVPVP ELYNRIFWNS FLISPVTPAH AGTYRCRGFH PHSPTEWSAP SNPLVIMVTG LYEKPSLTAR PGPTVRAGEN VTLSCSSQSS FDIYHLSREG EAHELRLPAV PSINGTFQAD FPLGPATHGE TYRCFGSFHG SPYEWSDPSD PLPVSVTGNP SSSWPSPTEP SFKTGIARHL H; Positive Samples: HeLa, SKOV3, PC-12, Mouse uterus, Mouse kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD158 antigen-like family member D; CD158d; G9P; Killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; Killer cell inhibitory receptor 103AS; killer Ig receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 2DL4; KIR-103AS; MHC class I NK cell receptor KIR103AS; natural killer cell inhibitory receptor; natural killer cell receptor; NK cell receptor
Gene Aliases: CD158D; G9P; KIR; KIR-103AS; KIR-2DL4; KIR103; KIR103AS; KIR2DL4
UniProt ID: (Human) Q99706
Entrez Gene ID: (Human) 3805
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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