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Alomone Labs, LTD
KISS1 Receptor (GPR54) (extracellular) Polyclonal Antibody
FIGURE: 1 / 3
KISS1 Receptor (GPR54) (extracellular) Antibody (AKR-001-200UL) in IHC (P)
Expression of KISS1R in rat pancreas - Immunohistochemical staining of paraffin embedded section of rat pancreas using Anti-KISS1 Receptor (GPR54) (extracellular) Antibody (#AKR-001), (1:100). KISS1R staining (brown) appears in Isles of Langerhans (IL). Hematoxilin is used as the counterstain.
Product Details
AKR-001-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)GSWHPRSYAAYALK, corresponding to amino acid residues 292-305 of human KISS1R, 3rd extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.75 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
GCPR54 is a galanin-like G protein coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the protein suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that it appears to play a role in the onset of puberty. GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; kiSS-; KiSS-1 receptor; KiSS-1R; Kisspeptins receptor; Metastin receptor; orphan G protein-coupled receptor GPR54; rOT7T175
Gene Aliases: AXOR12; CPPB1; GPR54; HH8; HOT7T175; KISS-1R; KISS1R
UniProt ID: (Human) Q969F8, (Rat) Q924U1
Entrez Gene ID: (Human) 84634, (Rat) 78976
activation of MAPKK activity
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
negative regulation of cell proliferation
calcium-mediated signaling
negative regulation of cell migration
positive regulation of hormone secretion
arachidonic acid secretion
positive regulation of synaptic transmission
positive regulation of stress fiber assembly
phospholipase C-activating G-protein coupled receptor signaling pathway
Performance Guarantee
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