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Invitrogen
KISS1R Polyclonal Antibody
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KISS1R Antibody (PA5-96221) in IHC (P)
Immunohistochemistry analysis of KISS1R in paraffin-embedded human B cell lymphoma. Samples were incubated with KISS1R Polyclonal antibody (Product # PA5-96221) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96221
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KISS1R (NP_1159402)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808023
Product Specific Information
Positive Samples: SW480; Cellular Location: Cell membrane, Multi-pass membrane protein
Immunogen sequence: ALHRLSPGPR AY
Target Information
GCPR54 is a galanin-like G protein coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the protein suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that it appears to play a role in the onset of puberty. GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; kiSS-; KiSS-1 receptor; KiSS-1R; Kisspeptins receptor; Metastin receptor; mOT7T175; orphan G protein-coupled receptor 54; orphan G protein-coupled receptor GPR54; rOT7T175
Gene Aliases: AXOR12; CPPB1; GPR54; HH8; HOT7T175; KiSS-1; KISS-1R; KISS1R
UniProt ID: (Human) Q969F8, (Mouse) Q91V45, (Rat) Q924U1
Entrez Gene ID: (Human) 84634, (Mouse) 114229, (Rat) 78976
activation of MAPKK activity
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
negative regulation of cell proliferation
calcium-mediated signaling
negative regulation of cell migration
positive regulation of hormone secretion
arachidonic acid secretion
positive regulation of synaptic transmission
positive regulation of stress fiber assembly
phospholipase C-activating G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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