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KLF 1, 2, 4, 5, 7, 12 Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

OSK00001W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the c-terminal of human Krueppel-like factor 1, 2, 4, 5, 7, 12 (KLF1, KLF2, KLF4, KLF5, KLF7, KLF12) conjugated to blue carrier protein was used as the antigen
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in many species including rat, mouse.

Specificity of this antibody: Krueppel-like factor 1, 2, 4, 5, 7, 12 (KLF1, KLF2, KLF4, KLF5, KLF7, KLF12).

Target Information

The Kruppel family of transcription factors (KLFs) are a set of C2H2-type zinc-finger DNA binding proteins that regulate gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: (intestinal Kruppel-like factor; AP-2 repressor; AP-2rep transcription factor; basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; colon kruppel-like factor; EKLF; endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; GC box binding protein 2; GC-box-binding protein 2; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; KLF12 zinc finger transcriptional repressor; Klf5C isoform; Krueppel-like factor 1; Krueppel-like factor 12; Krueppel-like factor 2; Krueppel-like factor 4; Krueppel-like factor 5; Krueppel-like factor 7; Kruppel-like factor 1 (erythroid); Kruppel-like factor 12; Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor 5 (intestinal); Kruppel-like factor 7 (ubiquitous); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; monoclonal antibody A3D8; neonatal anemia; Transcription factor BTEB2; Transcriptional repressor AP-2rep; truncated EKLF; truncated erythroid Kruppel-like factor 1; Ubiquitous krueppel-like factor; ubiquitous Kruppel-like factor; ubiquitous Kruppel-like transcription factor

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Gene Aliases: 2700063E05Rik; 4930520J07Rik; 9830124P08Rik; AI225908; AI315654; AP-2rep; AP2REP; B130052C06Rik; BTEB2; CDAN4; CKLF; D530033K05Rik; EKLF; EZF; GKLF; HBFQTL6; HSPC122; IKLF; INLU; KLF1; KLF12; KLF2; KLF4; KLF5; KLF7; LKLF; Nan; UKLF; Zie

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UniProt ID: (Human) Q13351, (Human) Q9Y4X4, (Human) Q9Y5W3, (Human) O43474, (Human) Q13887, (Human) O75840, (Mouse) O35738, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793, (Mouse) Q9Z0Z7, (Mouse) Q99JB0

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Entrez Gene ID: (Human) 10661, (Human) 11278, (Human) 10365, (Human) 9314, (Human) 688, (Human) 8609, (Mouse) 16596, (Rat) 304666, (Mouse) 16597, (Rat) 306110, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505, (Rat) 84410, (Mouse) 12224, (Mouse) 93691, (Rat) 363243

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Function(s)
core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity protein binding sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription cofactor binding beta-catenin binding zinc ion binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator activity nucleic acid binding protein domain specific binding activating transcription factor binding double-stranded DNA binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation microvillus assembly regulation of microvillus assembly skeletal muscle cell differentiation positive regulation of fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter intestinal epithelial cell development cellular response to organic cyclic compound cellular response to peptide transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter negative regulation of cell proliferation epidermal cell differentiation response to organic substance negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia stem cell population maintenance cell differentiation post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to retinoic acid negative regulation of heterotypic cell-cell adhesion post-embryonic hemopoiesis regulation of cell proliferation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation epidermis morphogenesis positive regulation of protein metabolic process negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis negative regulation of chemokine (C-X-C motif) ligand 2 production cell morphogenesis in utero embryonic development negative regulation of interleukin-6 production erythrocyte homeostasis multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation Type I pneumocyte differentiation liver development chromatin remodeling erythrocyte differentiation embryonic hemopoiesis erythrocyte development response to laminar fluid shear stress cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to cycloheximide axonogenesis axon guidance dendrite morphogenesis cellular response to retinoic acid mesodermal cell fate determination positive regulation of gene expression negative regulation of gene expression somatic stem cell population maintenance regulation of axon regeneration negative regulation of inflammatory response negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of transcription regulatory region DNA binding
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