Bioss

KLF1, 2, 4 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-9526R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human KLF1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EKLF; endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 1; Krueppel-like factor 2; Krueppel-like factor 4; Kruppel-like factor 1 (erythroid); Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; monoclonal antibody A3D8; neonatal anemia; truncated EKLF; truncated erythroid Kruppel-like factor 1

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Gene Aliases: CDAN4; EKLF; EZF; GKLF; HBFQTL6; INLU; KLF1; KLF2; KLF4; LKLF; Nan; Zie

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UniProt ID: (Human) Q13351, (Human) Q9Y5W3, (Human) O43474, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793

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Entrez Gene ID: (Human) 10661, (Human) 10365, (Human) 9314, (Rat) 304666, (Mouse) 16596, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505

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Function(s)
core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding protein binding sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription cofactor binding beta-catenin binding zinc ion binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding protein domain specific binding activating transcription factor binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter negative regulation of cell proliferation epidermal cell differentiation response to organic substance negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia stem cell population maintenance cell differentiation post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to retinoic acid negative regulation of heterotypic cell-cell adhesion post-embryonic hemopoiesis regulation of cell proliferation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation epidermis morphogenesis positive regulation of protein metabolic process negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis negative regulation of chemokine (C-X-C motif) ligand 2 production in utero embryonic development liver development chromatin remodeling erythrocyte differentiation embryonic hemopoiesis erythrocyte maturation erythrocyte development cellular response to peptide cell morphogenesis negative regulation of interleukin-6 production erythrocyte homeostasis multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to retinoic acid cellular response to organic cyclic compound cellular response to cycloheximide mesodermal cell fate determination positive regulation of gene expression negative regulation of gene expression somatic stem cell population maintenance regulation of axon regeneration negative regulation of inflammatory response negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of transcription regulatory region DNA binding response to laminar fluid shear stress cellular response to interleukin-1 cellular response to tumor necrosis factor
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