Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
KLF10 Recombinant Rabbit Monoclonal Antibody (23GB6605)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
KLF10 Antibody (MA5-53074) in WB
Western Blot analysis of KLF10. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with KLF10 recombinant monoclonal antibody (Product # MA5-53074) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Product Details
MA5-53074
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB6605
Immunogen
A synthesized peptide derived from human KLF10 (40-100AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3249549
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: early growth response-alpha; EGR-alpha; GDNF-inducible factor; Krueppel-like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; TIEG-1; Transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; Zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
Gene Aliases: AI115143; Cpg20; EGR-alpha; EGR[a]; EGRA; Egral; Gdnfif; KLF10; mGIF; TIEG; TIEG-1; TIEG1
UniProt ID: (Human) Q13118, (Rat) O08876, (Mouse) O89091
Entrez Gene ID: (Human) 7071, (Rat) 81813, (Mouse) 21847
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
cell-cell signaling
circadian rhythm
cell proliferation
negative regulation of cell proliferation
cellular response to starvation
bone mineralization
somatic stem cell population maintenance
regulation of circadian rhythm
positive regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
cellular response to peptide
regulation of transcription, DNA-templated
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support